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A1JT46 (MTLD_YERE8) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:YE4147
OrganismYersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) [Complete proteome] [HAMAP]
Taxonomic identifier393305 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_1000011820

Regions

Nucleotide binding3 – 1412NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A1JT46 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 53D2840A5CE48B2F

FASTA38741,969
        10         20         30         40         50         60 
MKALHFGAGN IGRGFIGKLL ADAGAQLTFA DVNQPLLDEL NKRKSYQVNV VGEQARVEEV 

        70         80         90        100        110        120 
KNVSAVNSGS PEVVELIAQA DMVTTAVGPQ ILARIAGTVA QGLVTRHQQG NTRPLNIIAC 

       130        140        150        160        170        180 
ENMVRGTSQL KQQVFAALPE SEQAWVEQHV GFVDSAVDRI VPPSEAGSTD ILAVTVETFS 

       190        200        210        220        230        240 
EWIVDGTQFK GQPPQIAGME LTDNLMAFVE RKLFTLNTGH AITAYLGQLA GHQTIRDAIL 

       250        260        270        280        290        300 
DPAVRQTVKG AMEESGAVLI KRYAFDPLKH AAYIEKILSR FENPYLHDDV ERVGRQPLRK 

       310        320        330        340        350        360 
LSAGDRLIKP LLGTLEYQLP HNNLVTGIAA AMSYRSEQDP QAQELVELLA KLGPKATLAQ 

       370        380 
ISGLPADSEV VEQAVSVYNA MQDKLAH

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References

[1]"The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081."
Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L., Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T., Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S., Sanders M., Whitehead S. expand/collapse author list , Quail M.A., Dougan G., Parkhill J., Prentice M.B.
PLoS Genet. 2:2039-2051(2006) [PubMed: 17173484] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 8081.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM286415 Genomic DNA. Translation: CAL14163.1.
RefSeqYP_001008392.1. NC_008800.1.

3D structure databases

ProteinModelPortalA1JT46.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1JT46.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4716541.
GenomeReviewsGene locus YE4147 in contig AM286415_GR.
KEGGyen:YE4147.
NMPDRfig|630.2.peg.4072.
PATRIC18568178. VBIYerEnt11519_4413.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0246.
HOGENOMHBG568825.
OMAFANTAVD.
PhylomeDBA1JT46.
ProtClustDBPRK02318.

Enzyme and pathway databases

BioCycYENT393305:YE4147-MONOMER.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_YERE8
AccessionPrimary (citable) accession number: A1JT46
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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