A1JSK7 (IOLG_YERE8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	YE4026

Organism

Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) [Complete proteome] [HAMAP]

Taxonomic identifier

393305 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352599

Sequences

	Sequence		Length	Mass (Da)
	A1JSK7 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 10508CE417F0707F	FASTA	337	37,150
	10 20 30 40 50 60 MSLNIGVIGT GAIGQDHIRR CSKVLQGSRI VAVTDINRES ATKVIRDLGI EANVYADGYE 70 80 90 100 110 120 VINAKEVEAV LVTSWGPSHE EFVLAAVAAG KYVFCEKPLA VTAEGCKRIV EAEAAQGKRL 130 140 150 160 170 180 VQVGFMRPYD QGYRALKDVI TSGKIGEPLM LHCAHRNPRV GDNYTTSMAI TDTLIHEIDV 190 200 210 220 230 240 LRWLLDDDYV SVQVVFPRKA KHAKTHLRDP QVVLFETAKG TRIDVEIFVN CQYGYDIQCE 250 260 270 280 290 300 VVGDSGIAKL PEPSSVLLRS EARLSNEILT DWKDRFIDAY DVELQAFIND VLAEKLTGPS 310 320 330 AWDGFAAAVT ADACIAAQES GQIVPIRLPQ RPDFYDK

References

[1]

"The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081." Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L., Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T., Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S., Sanders M., Whitehead S. , Quail M.A., Dougan G., Parkhill J., Prentice M.B. PLoS Genet. 2:2039-2051(2006) [PubMed: 17173484] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 8081.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM286415 Genomic DNA. Translation: CAL14044.1.
RefSeq	YP_001008169.1. NC_008800.1.
3D structure databases
ProteinModelPortal	A1JSK7.
ModBase	Search...
Protein-protein interaction databases
STRING	A1JSK7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4716317.
GenomeReviews	Gene locus YE4026 in contig AM286415_GR.
KEGG	yen:YE4026.
NMPDR	fig|630.2.peg.3954.
PATRIC	18567922. VBIYerEnt11519_4286.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
OMA	YDVELQD.
ProtClustDB	CLSK2785235.
Enzyme and pathway databases
BioCyc	YENT393305:YE4026-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_YERE8

Accession

Primary (citable) accession number: A1JSK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program