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Protein

Inosose dehydratase

Gene

iolE

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).UniRule annotation

Catalytic activityi

2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • glutathioneUniRule annotation
  • Co2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Cobalt, Manganese

Names & Taxonomyi

Protein namesi
Recommended name:
Inosose dehydrataseUniRule annotation (EC:4.2.1.44UniRule annotation)
Alternative name(s):
2-keto-myo-inositol dehydrataseUniRule annotation
Short name:
2KMI dehydrataseUniRule annotation
Gene namesi
Name:iolEUniRule annotation
Ordered Locus Names:YE4025
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000000642 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Inosose dehydratasePRO_0000352381Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi393305.YE4025.

Structurei

3D structure databases

ProteinModelPortaliA1JSK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IolE/MocC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJK. Bacteria.
COG1082. LUCA.
HOGENOMiHOG000239720.
KOiK03335.
OMAiYIRQHAG.
OrthoDBiEOG6HB9S9.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_01672. IolE.
InterProiIPR023952. IolE.
IPR030823. IolE/MocC.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR12110:SF4. PTHR12110:SF4. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR04379. myo_inos_iolE. 1 hit.

Sequencei

Sequence statusi: Complete.

A1JSK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKDRVKLAI APIGWTNDDM PDLGKENTFQ QCISEMALAG FIGSEVGSKY
60 70 80 90 100
PRDPNVLKPM LELRGMQICN AWFSTFFADG QRARTIDEFT NHMNFLHAMG
110 120 130 140 150
AKVIGCSEQS KSIQGTTKAI FEEKPYFTDT EWQRVAEGYN ELAKIAATKG
160 170 180 190 200
MQVCLHHHMG TGIQTTEEID RYMSMVNDDV YLLFDTGHAY YSEGSQEAML
210 220 230 240 250
AILEKYLPRI NHVHLKDVRD EVVAEVKAKK LSFLDGVKKG TFTVPGDGVI
260 270 280 290
DFRPVFKLLD EKGYQGWMVV EAEQDPAIAN PFEYAVKARR YIKETAGI
Length:298
Mass (Da):33,627
Last modified:February 6, 2007 - v1
Checksum:i7450D50DCB54E56A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL14043.1.
RefSeqiWP_011817366.1. NC_008800.1.
YP_001008389.1. NC_008800.1.

Genome annotation databases

EnsemblBacteriaiCAL14043; CAL14043; YE4025.
GeneIDi4716316.
KEGGiyen:YE4025.
PATRICi18567920. VBIYerEnt11519_4285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL14043.1.
RefSeqiWP_011817366.1. NC_008800.1.
YP_001008389.1. NC_008800.1.

3D structure databases

ProteinModelPortaliA1JSK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi393305.YE4025.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL14043; CAL14043; YE4025.
GeneIDi4716316.
KEGGiyen:YE4025.
PATRICi18567920. VBIYerEnt11519_4285.

Phylogenomic databases

eggNOGiENOG4105CJK. Bacteria.
COG1082. LUCA.
HOGENOMiHOG000239720.
KOiK03335.
OMAiYIRQHAG.
OrthoDBiEOG6HB9S9.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_01672. IolE.
InterProiIPR023952. IolE.
IPR030823. IolE/MocC.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PANTHERiPTHR12110:SF4. PTHR12110:SF4. 1 hit.
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR04379. myo_inos_iolE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 13174 / 8081.

Entry informationi

Entry nameiIOLE_YERE8
AccessioniPrimary (citable) accession number: A1JSK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: February 6, 2007
Last modified: November 11, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.