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Protein

HTH-type transcriptional regulator MalT

Gene

malT

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.UniRule annotation

Enzyme regulationi

Activated by ATP and maltotriose, which are both required for DNA binding.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 46ATPUniRule annotation8
DNA bindingi856 – 875H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processCarbohydrate metabolism, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator MalTUniRule annotation
Alternative name(s):
ATP-dependent transcriptional activator MalTUniRule annotation
Gene namesi
Name:malTUniRule annotation
Ordered Locus Names:YE3990
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000642 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000857831 – 903HTH-type transcriptional regulator MalTAdd BLAST903

Proteomic databases

PRIDEiA1JSF2

Interactioni

Subunit structurei

Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.UniRule annotation

Protein-protein interaction databases

STRINGi393305.YE3990

Structurei

3D structure databases

ProteinModelPortaliA1JSF2
SMRiA1JSF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini832 – 897HTH luxR-typeUniRule annotationAdd BLAST66

Sequence similaritiesi

Belongs to the MalT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41061ZR Bacteria
COG2909 LUCA
HOGENOMiHOG000218261
KOiK03556
OMAiSDWVSNA
OrthoDBiPOG091H0FN0

Family and domain databases

CDDicd06170 LuxR_C_like, 1 hit
Gene3Di1.10.10.10, 1 hit
1.25.40.10, 1 hit
HAMAPiMF_01247 HTH_type_MalT, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR011990 TPR-like_helical_dom_sf
IPR023768 Tscrpt_reg_HTH_MalT
IPR000792 Tscrpt_reg_LuxR_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00196 GerE, 1 hit
PRINTSiPR00038 HTHLUXR
SMARTiView protein in SMART
SM00421 HTH_LUXR, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
SSF48452 SSF48452, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00622 HTH_LUXR_1, 1 hit
PS50043 HTH_LUXR_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1JSF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIPSKLSRP VRLQNTVIRD RLLVKLSGVA NYRLTLINCP AGYGKTTLIA
60 70 80 90 100
QWAADQSDLG WYSLDESDNQ PERFATYLVA AIQLATGGHC SKSEAISQKH
110 120 130 140 150
QYASLSALFA QLFIELSEWD GPLYLVIDDY HLITNDAIHE AMRFFLRHQP
160 170 180 190 200
ENLTLIMLSR TLPPLGIANL RVRDQLLELG MQQLAFNHQE AQQFFDCRLS
210 220 230 240 250
VPLEQGDSSR LCDEVEGWAT ALQLIALSSR QPNSSAQKSA KRLAGLNASH
260 270 280 290 300
LSDYLVDEVL DQVDSDARAF LLRCSVLRSM NDALIVRLTG EDNGQQRLEE
310 320 330 340 350
LERQGLFIHR MDDSGEWFCF HPLFATFLRQ RCQWEMALEL PELHHAAAEG
360 370 380 390 400
WMALGYPAEA IHHALAAGDV GMLRDILLQH AWTLFNHSEL ALLEQCLVAL
410 420 430 440 450
PYSLLVQNPE LALLQAWLAQ SQHRYGEVNT LLERAESAMQ ERKIPIDEIL
460 470 480 490 500
RAEFDALRAQ VAINAGKPEE AEKLATDALK YLPMANFYSR IVATSVTGEV
510 520 530 540 550
HHCKGELSRA LPMMQQTEQM ARRHEAYHYA LWALLQQSEI LIAQGFLQAA
560 570 580 590 600
YETQDKAFDL IHEQHLEQLP MHEFLLRIRS QVLWSWSRLD EAEEAARKGI
610 620 630 640 650
EILVNYQPQQ QLQCLAMLAK CSLARGDLDN ANMYIQRCEA LQHGSQYHLD
660 670 680 690 700
WITNADKPRV IHWQMTGDKA AAANWLRQAE KPGMADNHFL QGQWRNIARI
710 720 730 740 750
QIMLGRFNEA EVVLDELNEN ARRLRLTSDL NRNLLLSNIL YWQTERKSEA
760 770 780 790 800
QKALIESLSL ANRTGFISHF VIEGEVMAQQ LRQLIQLNAL PELEQHRAQR
810 820 830 840 850
ILKDINQHHR HKFAHFDEIF VDKLLTHPQV PELIRTSPLT QREWQVLGLI
860 870 880 890 900
YSGYSNDQIA GELEVAATTI KTHIRNLYQK LGVAHRQDAV QQAQRLLQMM

GYV
Length:903
Mass (Da):103,209
Last modified:February 6, 2007 - v1
Checksum:iBFFE9677F9E7D450
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA Translation: CAL14010.1
RefSeqiWP_011817355.1, NC_008800.1
YP_001008136.1, NC_008800.1

Genome annotation databases

EnsemblBacteriaiCAL14010; CAL14010; YE3990
GeneIDi4716203
KEGGiyen:YE3990
PATRICifig|393305.7.peg.4248

Similar proteinsi

Entry informationi

Entry nameiMALT_YERE8
AccessioniPrimary (citable) accession number: A1JSF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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