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Protein

Rhomboid protease GlpG

Gene

glpG

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Rhomboid-type serine protease that catalyzes intramembrane proteolysis.UniRule annotation

Catalytic activityi

Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei202NucleophileUniRule annotation1
Active sitei255UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS54.016

Names & Taxonomyi

Protein namesi
Recommended name:
Rhomboid protease GlpGUniRule annotation (EC:3.4.21.105UniRule annotation)
Alternative name(s):
Intramembrane serine proteaseUniRule annotation
Gene namesi
Name:glpGUniRule annotation
Ordered Locus Names:YE3988
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000642 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei95 – 115HelicalUniRule annotationAdd BLAST21
Transmembranei143 – 163HelicalUniRule annotationAdd BLAST21
Transmembranei170 – 190HelicalUniRule annotationAdd BLAST21
Transmembranei192 – 212HelicalUniRule annotationAdd BLAST21
Transmembranei224 – 241HelicalUniRule annotationAdd BLAST18
Transmembranei245 – 267HelicalUniRule annotationAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003216991 – 278Rhomboid protease GlpGAdd BLAST278

Interactioni

Protein-protein interaction databases

STRINGi393305.YE3988

Structurei

3D structure databases

ProteinModelPortaliA1JSF0
SMRiA1JSF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S54 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EBW Bacteria
COG0705 LUCA
HOGENOMiHOG000269640
KOiK02441
OMAiHFSAMHI
OrthoDBiPOG091H059R

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
3.30.70.2350, 1 hit
HAMAPiMF_01594 Rhomboid_GlpG, 1 hit
InterProiView protein in InterPro
IPR038236 GlpG_N_sf
IPR022732 Peptidase_S54_GlpG_N
IPR002610 Peptidase_S54_rhomboid
IPR022764 Peptidase_S54_rhomboid_dom
IPR035952 Rhomboid-like_sf
IPR023662 Rhomboid_protease_GlpG
PANTHERiPTHR22936 PTHR22936, 1 hit
PfamiView protein in Pfam
PF01694 Rhomboid, 1 hit
PF12122 Rhomboid_N, 1 hit
TIGRFAMsiTIGR04239 rhombo_GlpG, 1 hit

Sequencei

Sequence statusi: Complete.

A1JSF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRVIAISNL RLAQAFVDYM ATRHVALEVK PDSQGAEIWL TDDEQLPQVQ
60 70 80 90 100
HELEQFLLDP LNPRYQAASW QSGNLHSNLP YQRFSYLQTL RSQAGPLTLS
110 120 130 140 150
VMVLCIAIYI LMQIVGDGAV MSWLAWPRDN SQYLQIWRWV SHAFLHFSLL
160 170 180 190 200
HILFNLMWWW YLAGQMEKRL GTGKLLVLTI VSALFSGWGQ SLFSGVNFGG
210 220 230 240 250
LSGVVYALMG YVWLTGERAP ERGISLPRGL MAFSVLWLVA GYFDILGLSI
260 270
ANAAHVSGLI IGLLMAFWDT RNSAKTTQ
Length:278
Mass (Da):31,336
Last modified:February 6, 2007 - v1
Checksum:i28832C62E4335902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA Translation: CAL14008.1
RefSeqiWP_005174723.1, NC_008800.1
YP_001008134.1, NC_008800.1

Genome annotation databases

EnsemblBacteriaiCAL14008; CAL14008; YE3988
GeneIDi4716201
KEGGiyen:YE3988
PATRICifig|393305.7.peg.4246

Similar proteinsi

Entry informationi

Entry nameiGLPG_YERE8
AccessioniPrimary (citable) accession number: A1JSF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health