Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rhomboid protease GlpG

Gene

glpG

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Rhomboid-type serine protease that catalyzes intramembrane proteolysis.UniRule annotation

Catalytic activityi

Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei202 – 2021NucleophileUniRule annotation
Active sitei255 – 2551UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS54.016.

Names & Taxonomyi

Protein namesi
Recommended name:
Rhomboid protease GlpGUniRule annotation (EC:3.4.21.105UniRule annotation)
Alternative name(s):
Intramembrane serine proteaseUniRule annotation
Gene namesi
Name:glpGUniRule annotation
Ordered Locus Names:YE3988
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000000642 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei95 – 11521HelicalUniRule annotationAdd
BLAST
Transmembranei143 – 16321HelicalUniRule annotationAdd
BLAST
Transmembranei170 – 19021HelicalUniRule annotationAdd
BLAST
Transmembranei192 – 21221HelicalUniRule annotationAdd
BLAST
Transmembranei224 – 24118HelicalUniRule annotationAdd
BLAST
Transmembranei245 – 26723HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Rhomboid protease GlpGPRO_0000321699Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi393305.YE3988.

Structurei

3D structure databases

ProteinModelPortaliA1JSF0.
SMRiA1JSF0. Positions 94-272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S54 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EBW. Bacteria.
COG0705. LUCA.
HOGENOMiHOG000269640.
KOiK02441.
OMAiHFSAMHI.
OrthoDBiEOG60SCRR.

Family and domain databases

Gene3Di1.20.1540.10. 1 hit.
HAMAPiMF_01594. Rhomboid_GlpG.
InterProiIPR022732. Peptidase_S54_GlpG_N.
IPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
IPR023662. Rhomboid_protease_GlpG.
[Graphical view]
PANTHERiPTHR22936. PTHR22936. 1 hit.
PfamiPF01694. Rhomboid. 1 hit.
PF12122. Rhomboid_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04239. rhombo_GlpG. 1 hit.

Sequencei

Sequence statusi: Complete.

A1JSF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRVIAISNL RLAQAFVDYM ATRHVALEVK PDSQGAEIWL TDDEQLPQVQ
60 70 80 90 100
HELEQFLLDP LNPRYQAASW QSGNLHSNLP YQRFSYLQTL RSQAGPLTLS
110 120 130 140 150
VMVLCIAIYI LMQIVGDGAV MSWLAWPRDN SQYLQIWRWV SHAFLHFSLL
160 170 180 190 200
HILFNLMWWW YLAGQMEKRL GTGKLLVLTI VSALFSGWGQ SLFSGVNFGG
210 220 230 240 250
LSGVVYALMG YVWLTGERAP ERGISLPRGL MAFSVLWLVA GYFDILGLSI
260 270
ANAAHVSGLI IGLLMAFWDT RNSAKTTQ
Length:278
Mass (Da):31,336
Last modified:February 6, 2007 - v1
Checksum:i28832C62E4335902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL14008.1.
RefSeqiWP_005174723.1. NC_008800.1.
YP_001008134.1. NC_008800.1.

Genome annotation databases

EnsemblBacteriaiCAL14008; CAL14008; YE3988.
GeneIDi4716201.
KEGGiyen:YE3988.
PATRICi18567842. VBIYerEnt11519_4246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL14008.1.
RefSeqiWP_005174723.1. NC_008800.1.
YP_001008134.1. NC_008800.1.

3D structure databases

ProteinModelPortaliA1JSF0.
SMRiA1JSF0. Positions 94-272.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi393305.YE3988.

Protein family/group databases

MEROPSiS54.016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL14008; CAL14008; YE3988.
GeneIDi4716201.
KEGGiyen:YE3988.
PATRICi18567842. VBIYerEnt11519_4246.

Phylogenomic databases

eggNOGiENOG4105EBW. Bacteria.
COG0705. LUCA.
HOGENOMiHOG000269640.
KOiK02441.
OMAiHFSAMHI.
OrthoDBiEOG60SCRR.

Family and domain databases

Gene3Di1.20.1540.10. 1 hit.
HAMAPiMF_01594. Rhomboid_GlpG.
InterProiIPR022732. Peptidase_S54_GlpG_N.
IPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
IPR023662. Rhomboid_protease_GlpG.
[Graphical view]
PANTHERiPTHR22936. PTHR22936. 1 hit.
PfamiPF01694. Rhomboid. 1 hit.
PF12122. Rhomboid_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04239. rhombo_GlpG. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 13174 / 8081.

Entry informationi

Entry nameiGLPG_YERE8
AccessioniPrimary (citable) accession number: A1JSF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2007
Last modified: November 11, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.