A1JS45 (ASTC_YERE8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinylornithine transaminase
EC=2.6.1.81

Alternative name(s):
Succinylornithine aminotransferase

Gene names

Name:	astC
Synonyms:	argM
Ordered Locus Names:	YE2469

Organism

Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) [Complete proteome] [HAMAP]

Taxonomic identifier

393305 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase By similarity. HAMAP MF_01173
Catalytic activity	N(2)-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate. HAMAP MF_01173
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01173
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 3/5. HAMAP MF_01173
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro succinylornithine transaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	Succinylornithine transaminase HAMAP MF_01173		PRO_1000164399
Amino acid modifications
	Modified residue	260	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1JS45 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 7BCE3CAEECC2C26F	FASTA	414	44,110
	10 20 30 40 50 60 MEQPIPVTRQ SFDEWIVPTY APADFIVVRG EGATLWDQQG KSYIDFAGGI AVNALGHGHP 70 80 90 100 110 120 AVKAALIEQA DKVWHLGNGY TNEPVLRLAK QLIDATFAEK VFFCNSGAEA NEAALKLARK 130 140 150 160 170 180 YALDNFANKP GQQGEKNQIV AFRNAFHGRT LFTVSAGGQP KYSQDFAPLP GGISHGIFND 190 200 210 220 230 240 LASAEALITD QTCAVIVEPI QGEGGVLPAD SEFLHGLRAL CDRHNAVLIF DEVQTGVGRT 250 260 270 280 290 300 GELYAYMHYG VTPDVLTSAK ALGGGFPIAA MLTTTKYASA LNVGSHGTTY GGNPLACAVA 310 320 330 340 350 360 GTVLSLINTP AVLSGVKERH QWFLEGLADI NARYKVFAEI RGRGLLIGCV LNSDYAGKSK 370 380 390 400 410 DIIQAAAQHG IIALIAGPDV VRFAPSLIIS QHDIKEGLAR LAMGIEQVCR KAKS

References

[1]

"The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081." Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L., Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T., Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S., Sanders M., Whitehead S. , Quail M.A., Dougan G., Parkhill J., Prentice M.B. PLoS Genet. 2:2039-2051(2006) [PubMed: 17173484] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 8081.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM286415 Genomic DNA. Translation: CAL12512.1.
RefSeq	YP_001006676.1. NC_008800.1.
3D structure databases
ProteinModelPortal	A1JS45.
SMR	A1JS45. Positions 17-408.
ModBase	Search...
Protein-protein interaction databases
STRING	A1JS45.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4712507.
GenomeReviews	Gene locus YE2469 in contig AM286415_GR.
KEGG	yen:YE2469.
NMPDR	fig|630.2.peg.2392.
PATRIC	18564526. VBIYerEnt11519_2620.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4992.
HOGENOM	HBG725944.
OMA	PERFRIV.
PhylomeDB	A1JS45.
ProtClustDB	PRK12381.
Enzyme and pathway databases
BioCyc	YENT393305:YE2469-MONOMER.
Family and domain databases
HAMAP	MF_01173. AstC_aminotrans_3. [Tree]
InterPro	IPR017652. Ac/SuccinylOrn_transaminase. IPR004636. AcOrn/SuccinylOrn_aminoTrfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KO	K00840.
PANTHER	PTHR11986. Aminotrans_3. 1 hit. PTHR11986:SF19. ArgD_aminotrans. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR03246. Arg_catab_astC. 1 hit. TIGR00707. ArgD. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTC_YERE8

Accession

Primary (citable) accession number: A1JS45

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program