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Protein

Biosynthetic peptidoglycan transglycosylase

Gene

mtgA

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.UniRule annotation

Catalytic activityi

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219

Protein family/group databases

CAZyiGT51 Glycosyltransferase Family 51

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic peptidoglycan transglycosylaseUniRule annotation (EC:2.4.1.129UniRule annotation)
Alternative name(s):
Glycan polymeraseUniRule annotation
Peptidoglycan glycosyltransferase MtgAUniRule annotation
Short name:
PGTUniRule annotation
Gene namesi
Name:mtgAUniRule annotation
Ordered Locus Names:YE3731
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000642 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 38HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000173181 – 241Biosynthetic peptidoglycan transglycosylaseAdd BLAST241

Interactioni

Protein-protein interaction databases

STRINGi393305.YE3731

Structurei

3D structure databases

ProteinModelPortaliA1JR77
SMRiA1JR77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 51 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108VKV Bacteria
COG0744 LUCA
HOGENOMiHOG000288117
KOiK03814
OMAiPAPKCFD
OrthoDBiPOG091H03R6

Family and domain databases

Gene3Di1.10.3810.10, 1 hit
HAMAPiMF_00766 PGT_MtgA, 1 hit
InterProiView protein in InterPro
IPR001264 Glyco_trans_51
IPR023346 Lysozyme-like_dom_sf
IPR036950 PBP_transglycosylase
IPR011812 Pep_trsgly
PANTHERiPTHR30400 PTHR30400, 1 hit
PfamiView protein in Pfam
PF00912 Transgly, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
TIGRFAMsiTIGR02070 mono_pep_trsgly, 1 hit

Sequencei

Sequence statusi: Complete.

A1JR77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISVRRGLNW LWYWGKRAVI GIVALWLAGI LIFAFLPVPF SMVMIERQLG
60 70 80 90 100
AWLTGDFSYV AHSDWVPMDE ISPYMALAVM AAEDQKFPEH WGFDVGAIES
110 120 130 140 150
ALAHNQRNQN RIRGASTLSQ QTAKNLFLWD GRSWVRKGLE VGLTAGIELV
160 170 180 190 200
WTKRRILTVY LNIAEFGDGI FGVEAAARHF FNKPASKLSA SEAALLAAVL
210 220 230 240
PNPLRFKANA PSGYVISRQQ WILRQMRQLG GKDFIQANDL D
Length:241
Mass (Da):27,091
Last modified:February 6, 2007 - v1
Checksum:i532ED70A1F148840
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA Translation: CAL13757.1
RefSeqiWP_005162387.1, NC_008800.1
YP_001007885.1, NC_008800.1

Genome annotation databases

EnsemblBacteriaiCAL13757; CAL13757; YE3731
GeneIDi4714131
KEGGiyen:YE3731
PATRICifig|393305.7.peg.3973

Similar proteinsi

Entry informationi

Entry nameiMTGA_YERE8
AccessioniPrimary (citable) accession number: A1JR77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health