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Protein

Biosynthetic peptidoglycan transglycosylase

Gene

mtgA

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.UniRule annotation

Catalytic activityi

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic peptidoglycan transglycosylaseUniRule annotation (EC:2.4.1.129UniRule annotation)
Alternative name(s):
Glycan polymeraseUniRule annotation
Peptidoglycan glycosyltransferase MtgAUniRule annotation
Short name:
PGTUniRule annotation
Gene namesi
Name:mtgAUniRule annotation
Ordered Locus Names:YE3731
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000642 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 38HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000173181 – 241Biosynthetic peptidoglycan transglycosylaseAdd BLAST241

Interactioni

Protein-protein interaction databases

STRINGi393305.YE3731.

Structurei

3D structure databases

ProteinModelPortaliA1JR77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 51 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108VKV. Bacteria.
COG0744. LUCA.
HOGENOMiHOG000288117.
KOiK03814.
OMAiQISAWLS.
OrthoDBiPOG093P00F2.

Family and domain databases

Gene3Di1.10.3810.10. 1 hit.
HAMAPiMF_00766. PGT_MtgA. 1 hit.
InterProiView protein in InterPro
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011812. Mono_pep_trsgly.
PfamiView protein in Pfam
PF00912. Transgly. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.
TIGRFAMsiTIGR02070. mono_pep_trsgly. 1 hit.

Sequencei

Sequence statusi: Complete.

A1JR77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISVRRGLNW LWYWGKRAVI GIVALWLAGI LIFAFLPVPF SMVMIERQLG
60 70 80 90 100
AWLTGDFSYV AHSDWVPMDE ISPYMALAVM AAEDQKFPEH WGFDVGAIES
110 120 130 140 150
ALAHNQRNQN RIRGASTLSQ QTAKNLFLWD GRSWVRKGLE VGLTAGIELV
160 170 180 190 200
WTKRRILTVY LNIAEFGDGI FGVEAAARHF FNKPASKLSA SEAALLAAVL
210 220 230 240
PNPLRFKANA PSGYVISRQQ WILRQMRQLG GKDFIQANDL D
Length:241
Mass (Da):27,091
Last modified:February 6, 2007 - v1
Checksum:i532ED70A1F148840
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL13757.1.
RefSeqiWP_005162387.1. NC_008800.1.
YP_001007885.1. NC_008800.1.

Genome annotation databases

EnsemblBacteriaiCAL13757; CAL13757; YE3731.
GeneIDi4714131.
KEGGiyen:YE3731.
PATRICi18567281. VBIYerEnt11519_3973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL13757.1.
RefSeqiWP_005162387.1. NC_008800.1.
YP_001007885.1. NC_008800.1.

3D structure databases

ProteinModelPortaliA1JR77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi393305.YE3731.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL13757; CAL13757; YE3731.
GeneIDi4714131.
KEGGiyen:YE3731.
PATRICi18567281. VBIYerEnt11519_3973.

Phylogenomic databases

eggNOGiENOG4108VKV. Bacteria.
COG0744. LUCA.
HOGENOMiHOG000288117.
KOiK03814.
OMAiQISAWLS.
OrthoDBiPOG093P00F2.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

Gene3Di1.10.3810.10. 1 hit.
HAMAPiMF_00766. PGT_MtgA. 1 hit.
InterProiView protein in InterPro
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011812. Mono_pep_trsgly.
PfamiView protein in Pfam
PF00912. Transgly. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.
TIGRFAMsiTIGR02070. mono_pep_trsgly. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTGA_YERE8
AccessioniPrimary (citable) accession number: A1JR77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: February 15, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.