ID   UXAB_YERE8              Reviewed;         483 AA.
AC   A1JR24;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Altronate oxidoreductase;
DE            EC=1.1.1.58;
DE   AltName: Full=Tagaturonate reductase;
DE   AltName: Full=Tagaturonate dehydrogenase;
GN   Name=uxaB; OrderedLocusNames=YE3707;
OS   Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Yersinia.
OX   NCBI_TaxID=393305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA   Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA   Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA   Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA   Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA   Prentice M.B.;
RT   "The complete genome sequence and comparative genome analysis of the
RT   high pathogenicity Yersinia enterocolitica strain 8081.";
RL   PLoS Genet. 2:2039-2051(2006).
CC   -!- CATALYTIC ACTIVITY: D-altronate + NAD(+) = D-tagaturonate + NADH.
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family. UxaB
CC       subfamily.
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DR   EMBL; AM286415; CAL13734.1; -; Genomic_DNA.
DR   RefSeq; YP_001007862.1; -.
DR   GeneID; 4714107; -.
DR   GenomeReviews; AM286415_GR; YE3707.
DR   KEGG; yen:YE3707; -.
DR   NMPDR; fig|630.2.peg.3641; -.
DR   OMA; A1JR24; SIFPCEL.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0009026; F:tagaturonate reductase activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00670; -; 1.
DR   InterPro; IPR013328; DH_multihelical.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    483       Altronate oxidoreductase.
FT                                /FTId=PRO_1000044709.
FT   NP_BIND      18     29       NAD (By similarity).
SQ   SEQUENCE   483 AA;  54845 MW;  C6A0F748FF597BD9 CRC64;
     MQTLNRRDFP GRSHPDKIIQ FGEGNFLRAF VDWQIDLLNE HTDLNAGIVV IRPIDTDFPP
     SLSTQDGLYT AVIRGLNEQG EAVRESRLIR SVNREINIYR QFDEYLALAR DPNIRFMFSN
     TTEAGIAWNE ADQFSDAPPS SFPAKLTRLL FERFEHFSGA ADKGWVLLPC ELIDYNGEAL
     RELVLRYASH WQLPAAFTQW LTENNTFCST LVDRIVTGYP RDEVAALQAE LGYQDSFLDT
     AEYFYLFVIQ GPKELAQELR LDKLDLNVRI VDDIKPYKER KVAILNGAHT ALVPVAYLSG
     LDTVGQTMDD VQISSFVEKT ITEEIVPVLD LPEDELLSFS QAVLSRFRNP FIQHQLLSIA
     LNGMTKFRTR ILPQLLTYQQ QQGKLPPRLT FALAALIAFY RGERDGQTYP LQDDAHWLER
     YSTLWNGVKH GDIKLAELVN TVLSDTAHWG QDLTAVPQLA NQVTEQLQTI IDSGMRAAVA
     AYS
//