A1JR24 (UXAB_YERE8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Altronate oxidoreductase
EC=1.1.1.58

Alternative name(s):
Tagaturonate dehydrogenase
Tagaturonate reductase

Gene names

Name:	uxaB
Ordered Locus Names:	YE3707

Organism

Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) [Complete proteome] [HAMAP]

Taxonomic identifier

393305 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia › Yersinia enterocolitica › Yersinia enterocolitica subsp. enterocolitica

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP-Rule MF_00670
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP-Rule MF_00670
Sequence similarities	Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	coenzyme binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro tagaturonate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 483	483	Altronate oxidoreductase HAMAP-Rule MF_00670		PRO_1000044709
Regions
	Nucleotide binding	18 – 29	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1JR24 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: C6A0F748FF597BD9	FASTA	483	54,845
	10 20 30 40 50 60 MQTLNRRDFP GRSHPDKIIQ FGEGNFLRAF VDWQIDLLNE HTDLNAGIVV IRPIDTDFPP 70 80 90 100 110 120 SLSTQDGLYT AVIRGLNEQG EAVRESRLIR SVNREINIYR QFDEYLALAR DPNIRFMFSN 130 140 150 160 170 180 TTEAGIAWNE ADQFSDAPPS SFPAKLTRLL FERFEHFSGA ADKGWVLLPC ELIDYNGEAL 190 200 210 220 230 240 RELVLRYASH WQLPAAFTQW LTENNTFCST LVDRIVTGYP RDEVAALQAE LGYQDSFLDT 250 260 270 280 290 300 AEYFYLFVIQ GPKELAQELR LDKLDLNVRI VDDIKPYKER KVAILNGAHT ALVPVAYLSG 310 320 330 340 350 360 LDTVGQTMDD VQISSFVEKT ITEEIVPVLD LPEDELLSFS QAVLSRFRNP FIQHQLLSIA 370 380 390 400 410 420 LNGMTKFRTR ILPQLLTYQQ QQGKLPPRLT FALAALIAFY RGERDGQTYP LQDDAHWLER 430 440 450 460 470 480 YSTLWNGVKH GDIKLAELVN TVLSDTAHWG QDLTAVPQLA NQVTEQLQTI IDSGMRAAVA AYS

References

[1]

"The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081." Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L., Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T., Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S., Sanders M., Whitehead S. , Quail M.A., Dougan G., Parkhill J., Prentice M.B. PLoS Genet. 2:2039-2051(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 8081.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM286415 Genomic DNA. Translation: CAL13734.1.
RefSeq	YP_001007862.1. NC_008800.1.
3D structure databases
ProteinModelPortal	A1JR24.
ModBase	Search...
Protein-protein interaction databases
STRING	393305.YE3707.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4714107.
KEGG	yen:YE3707.
PATRIC	18567229. VBIYerEnt11519_3947.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0246.
HOGENOM	HOG000029586.
KO	K00041.
OMA	HNTFCST.
ProtClustDB	PRK03643.
Enzyme and pathway databases
UniPathway	UPA00246.
Family and domain databases
Gene3D	1.10.1040.10. 1 hit. 3.40.50.720. 1 hit.
HAMAP	MF_00670. Altron_oxidoreduct.
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR023668. Altronate_OxRdtase. IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXAB_YERE8

Accession

Primary (citable) accession number: A1JR24

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program