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Protein

Glutamate decarboxylase

Gene

gadA

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadAImported
Ordered Locus Names:YE3693Imported
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)Imported
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000000642 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei276 – 2761N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi393305.YE3693.

Structurei

3D structure databases

ProteinModelPortaliA1JR00.
SMRiA1JR00. Positions 4-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CVK. Bacteria.
COG0076. LUCA.
HOGENOMiHOG000070228.
KOiK01580.
OMAiENTIGCF.
OrthoDBiPOG091H06F5.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1JR00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRKSLDDYR SDLLDSRFGS KAIRNISENK VFPKEEMRED IAFQIISDEL
60 70 80 90 100
FLDGNARQNL ATFCQTWDDD NVHKLMDLSI NKNWIDKEEY PQSAAIDMRC
110 120 130 140 150
VNMMADLWNA PTPKGAQGVG TNTIGSSEAC MLGGMAMKWR WRKKMEAAGK
160 170 180 190 200
PTNKPNFVCG PVQVCWHKFA RYWEVEIREI PMIPGQLFMD PQRMIEACDE
210 220 230 240 250
NTIGVVPTFG VTYTGNYELP KPLHDALDKL QKDTGLDIDM HIDAASGGFL
260 270 280 290 300
APFVAPDIEW DFRLPRVKSI STSGHKFGLA PLGCGWVIWR DAAALPEELI
310 320 330 340 350
FNVDYLGGQV GTFAINFSRP TGQVISQYYE FIRLGREGYT KVQSACYQVA
360 370 380 390 400
EFLAKEIAPL GPYEFYCSGG PYEGIPAICF RIKKGAKAGY TLYDLSERLR
410 420 430 440 450
LRGWQVPAFT LSGKMSDVVV MRIMCRRGFE MDFAGLLLDD FKSSLKYLSE
460
HPSLGGEASQ NSFSHT
Length:466
Mass (Da):52,486
Last modified:February 6, 2007 - v1
Checksum:iE9AD51E2773B30B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL13720.1.
RefSeqiWP_011817231.1. NC_008800.1.
YP_001007848.1. NC_008800.1.

Genome annotation databases

EnsemblBacteriaiCAL13720; CAL13720; YE3693.
GeneIDi4714092.
KEGGiyen:YE3693.
PATRICi18567201. VBIYerEnt11519_3933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL13720.1.
RefSeqiWP_011817231.1. NC_008800.1.
YP_001007848.1. NC_008800.1.

3D structure databases

ProteinModelPortaliA1JR00.
SMRiA1JR00. Positions 4-466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi393305.YE3693.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL13720; CAL13720; YE3693.
GeneIDi4714092.
KEGGiyen:YE3693.
PATRICi18567201. VBIYerEnt11519_3933.

Phylogenomic databases

eggNOGiENOG4105CVK. Bacteria.
COG0076. LUCA.
HOGENOMiHOG000070228.
KOiK01580.
OMAiENTIGCF.
OrthoDBiPOG091H06F5.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA1JR00_YERE8
AccessioniPrimary (citable) accession number: A1JR00
Entry historyi
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.