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A1JPN3

- GCSP_YERE8

UniProt

A1JPN3 - GCSP_YERE8

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:YE3391
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000642: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 959959Glycine dehydrogenase (decarboxylating)PRO_1000045629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei708 – 7081N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi393305.YE3391.

Structurei

3D structure databases

ProteinModelPortaliA1JPN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A1JPN3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQNLSQLEH NDAFIQRHIG SSAEQQQQML AAVGANSLST LIQQIVPADI
60 70 80 90 100
QLPSPPPVGE AATEHQALAE LKGIASQNQR YKSYIGMGYS PVLTPPVILR
110 120 130 140 150
NMLENPGWYT AYTPYQPEVS QGRLEALLNF QQLTQDLTGL DLASASLLDE
160 170 180 190 200
ATAAAESMAL AKRASKLKDA NRFFVADDVH PQTLDVVLTR AETFGFEVIV
210 220 230 240 250
DRAEKVLELD GVFGVLLQQV GTTGELHDYS ALLAELKKRK IITSVAADIM
260 270 280 290 300
ALVLLTAPGK QGADVVFGSA QRFGVPMGYG GPHAAFFACR DEFKRSMPGR
310 320 330 340 350
IIGVSRDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV
360 370 380 390 400
YHGPQGLQRI AGRIHRMTDI LAAGLQQAGL ALRFTHWFDT LTVEVKDKAA
410 420 430 440 450
VLARALSFGI NLRTDIHGAV GITLDETTSR EDLQILFTLL VGDNHGLDID
460 470 480 490 500
LLDAKVSQNS QSIQTGMLRQ EPILTHPVFN RYHSETEMMR YMHRLERKDL
510 520 530 540 550
ALNQAMIPLG SCTMKLNAAA EMIPITWPEF AELHPFCPPE QAAGYQQMIG
560 570 580 590 600
QLSQWLVQLT GYDAVCMQPN SGAQGEYAGL LAIRRYHESR NQASRHICLI
610 620 630 640 650
PSSAHGTNPA SAQMAGMSVV VVACDKQGNI DLHDLRQKAG EAGDELSCIM
660 670 680 690 700
VTYPSTHGVY EETIREVCQI VHQFGGQVYL DGANMNAQVG ITTPGYIGAD
710 720 730 740 750
VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHSVV QIDGMTTQQG
760 770 780 790 800
AVSAAPFGSA SILPISWMYI RMMGADGLKQ ASQVAILNAN YIATRLKEAY
810 820 830 840 850
PVLYTGHDGS VAHECILDIR PLKEATGISE MDIAKRLIDF GFHAPTMSFP
860 870 880 890 900
VAGTLMVEPT ESESKVELDR FIDAMLAIRA EIEKVARGEW PLEDNPLVNA
910 920 930 940 950
PHTQAELVGE WQHPYSRELA VFPVAGVMEN KYWPSVKRLD DVYGDRNLFC

SCVPISDYE
Length:959
Mass (Da):104,678
Last modified:February 6, 2007 - v1
Checksum:i5B50694291651441
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286415 Genomic DNA. Translation: CAL13417.1.
RefSeqiYP_001007560.1. NC_008800.1.

Genome annotation databases

EnsemblBacteriaiCAL13417; CAL13417; YE3391.
GeneIDi4713784.
KEGGiyen:YE3391.
PATRICi18566535. VBIYerEnt11519_3601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286415 Genomic DNA. Translation: CAL13417.1 .
RefSeqi YP_001007560.1. NC_008800.1.

3D structure databases

ProteinModelPortali A1JPN3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393305.YE3391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL13417 ; CAL13417 ; YE3391 .
GeneIDi 4713784.
KEGGi yen:YE3391.
PATRICi 18566535. VBIYerEnt11519_3601.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 13174 / 8081.

Entry informationi

Entry nameiGCSP_YERE8
AccessioniPrimary (citable) accession number: A1JPN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3