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A1JPN3 (GCSP_YERE8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:YE3391
OrganismYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) [Complete proteome] [HAMAP]
Taxonomic identifier393305 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length959 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 959959Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045629

Amino acid modifications

Modified residue7081N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A1JPN3 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 5B50694291651441

FASTA959104,678
        10         20         30         40         50         60 
MTQNLSQLEH NDAFIQRHIG SSAEQQQQML AAVGANSLST LIQQIVPADI QLPSPPPVGE 

        70         80         90        100        110        120 
AATEHQALAE LKGIASQNQR YKSYIGMGYS PVLTPPVILR NMLENPGWYT AYTPYQPEVS 

       130        140        150        160        170        180 
QGRLEALLNF QQLTQDLTGL DLASASLLDE ATAAAESMAL AKRASKLKDA NRFFVADDVH 

       190        200        210        220        230        240 
PQTLDVVLTR AETFGFEVIV DRAEKVLELD GVFGVLLQQV GTTGELHDYS ALLAELKKRK 

       250        260        270        280        290        300 
IITSVAADIM ALVLLTAPGK QGADVVFGSA QRFGVPMGYG GPHAAFFACR DEFKRSMPGR 

       310        320        330        340        350        360 
IIGVSRDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV YHGPQGLQRI 

       370        380        390        400        410        420 
AGRIHRMTDI LAAGLQQAGL ALRFTHWFDT LTVEVKDKAA VLARALSFGI NLRTDIHGAV 

       430        440        450        460        470        480 
GITLDETTSR EDLQILFTLL VGDNHGLDID LLDAKVSQNS QSIQTGMLRQ EPILTHPVFN 

       490        500        510        520        530        540 
RYHSETEMMR YMHRLERKDL ALNQAMIPLG SCTMKLNAAA EMIPITWPEF AELHPFCPPE 

       550        560        570        580        590        600 
QAAGYQQMIG QLSQWLVQLT GYDAVCMQPN SGAQGEYAGL LAIRRYHESR NQASRHICLI 

       610        620        630        640        650        660 
PSSAHGTNPA SAQMAGMSVV VVACDKQGNI DLHDLRQKAG EAGDELSCIM VTYPSTHGVY 

       670        680        690        700        710        720 
EETIREVCQI VHQFGGQVYL DGANMNAQVG ITTPGYIGAD VSHLNLHKTF CIPHGGGGPG 

       730        740        750        760        770        780 
MGPIGVKAHL APFVPGHSVV QIDGMTTQQG AVSAAPFGSA SILPISWMYI RMMGADGLKQ 

       790        800        810        820        830        840 
ASQVAILNAN YIATRLKEAY PVLYTGHDGS VAHECILDIR PLKEATGISE MDIAKRLIDF 

       850        860        870        880        890        900 
GFHAPTMSFP VAGTLMVEPT ESESKVELDR FIDAMLAIRA EIEKVARGEW PLEDNPLVNA 

       910        920        930        940        950 
PHTQAELVGE WQHPYSRELA VFPVAGVMEN KYWPSVKRLD DVYGDRNLFC SCVPISDYE 

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References

[1]"The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081."
Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L., Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T., Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S., Sanders M., Whitehead S. expand/collapse author list , Quail M.A., Dougan G., Parkhill J., Prentice M.B.
PLoS Genet. 2:2039-2051(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 13174 / 8081.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM286415 Genomic DNA. Translation: CAL13417.1.
RefSeqYP_001007560.1. NC_008800.1.

3D structure databases

ProteinModelPortalA1JPN3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING393305.YE3391.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL13417; CAL13417; YE3391.
GeneID4713784.
KEGGyen:YE3391.
PATRIC18566535. VBIYerEnt11519_3601.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_YERE8
AccessionPrimary (citable) accession number: A1JPN3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families