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A1JPN3

- GCSP_YERE8

UniProt

A1JPN3 - GCSP_YERE8

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, YE3391
Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:YE3391
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000642: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 959959Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000045629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei708 – 7081N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi393305.YE3391.

Structurei

3D structure databases

ProteinModelPortaliA1JPN3.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A1JPN3-1 [UniParc]FASTAAdd to Basket

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MTQNLSQLEH NDAFIQRHIG SSAEQQQQML AAVGANSLST LIQQIVPADI    50
QLPSPPPVGE AATEHQALAE LKGIASQNQR YKSYIGMGYS PVLTPPVILR 100
NMLENPGWYT AYTPYQPEVS QGRLEALLNF QQLTQDLTGL DLASASLLDE 150
ATAAAESMAL AKRASKLKDA NRFFVADDVH PQTLDVVLTR AETFGFEVIV 200
DRAEKVLELD GVFGVLLQQV GTTGELHDYS ALLAELKKRK IITSVAADIM 250
ALVLLTAPGK QGADVVFGSA QRFGVPMGYG GPHAAFFACR DEFKRSMPGR 300
IIGVSRDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV 350
YHGPQGLQRI AGRIHRMTDI LAAGLQQAGL ALRFTHWFDT LTVEVKDKAA 400
VLARALSFGI NLRTDIHGAV GITLDETTSR EDLQILFTLL VGDNHGLDID 450
LLDAKVSQNS QSIQTGMLRQ EPILTHPVFN RYHSETEMMR YMHRLERKDL 500
ALNQAMIPLG SCTMKLNAAA EMIPITWPEF AELHPFCPPE QAAGYQQMIG 550
QLSQWLVQLT GYDAVCMQPN SGAQGEYAGL LAIRRYHESR NQASRHICLI 600
PSSAHGTNPA SAQMAGMSVV VVACDKQGNI DLHDLRQKAG EAGDELSCIM 650
VTYPSTHGVY EETIREVCQI VHQFGGQVYL DGANMNAQVG ITTPGYIGAD 700
VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHSVV QIDGMTTQQG 750
AVSAAPFGSA SILPISWMYI RMMGADGLKQ ASQVAILNAN YIATRLKEAY 800
PVLYTGHDGS VAHECILDIR PLKEATGISE MDIAKRLIDF GFHAPTMSFP 850
VAGTLMVEPT ESESKVELDR FIDAMLAIRA EIEKVARGEW PLEDNPLVNA 900
PHTQAELVGE WQHPYSRELA VFPVAGVMEN KYWPSVKRLD DVYGDRNLFC 950
SCVPISDYE 959
Length:959
Mass (Da):104,678
Last modified:February 6, 2007 - v1
Checksum:i5B50694291651441
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286415 Genomic DNA. Translation: CAL13417.1.
RefSeqiWP_011817028.1. NC_008800.1.
YP_001007560.1. NC_008800.1.

Genome annotation databases

EnsemblBacteriaiCAL13417; CAL13417; YE3391.
GeneIDi4713784.
KEGGiyen:YE3391.
PATRICi18566535. VBIYerEnt11519_3601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286415 Genomic DNA. Translation: CAL13417.1 .
RefSeqi WP_011817028.1. NC_008800.1.
YP_001007560.1. NC_008800.1.

3D structure databases

ProteinModelPortali A1JPN3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 393305.YE3391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL13417 ; CAL13417 ; YE3391 .
GeneIDi 4713784.
KEGGi yen:YE3391.
PATRICi 18566535. VBIYerEnt11519_3601.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 13174 / 8081.

Entry informationi

Entry nameiGCSP_YERE8
AccessioniPrimary (citable) accession number: A1JPN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi