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Protein

Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase

Gene

arnT

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityi

4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate.UniRule annotation

Pathwayi: 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis

This protein is involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis, which is part of Lipopolysaccharide metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis and in Lipopolysaccharide metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00037.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferaseUniRule annotation (EC:2.4.2.43UniRule annotation)
Alternative name(s):
4-amino-4-deoxy-L-arabinose lipid A transferaseUniRule annotation
Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferaseUniRule annotation
Undecaprenyl phosphate-alpha-L-Ara4N transferaseUniRule annotation
Gene namesi
Name:arnTUniRule annotation
Ordered Locus Names:YE2188
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000642 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalUniRule annotationAdd BLAST21
Transmembranei87 – 107HelicalUniRule annotationAdd BLAST21
Transmembranei115 – 135HelicalUniRule annotationAdd BLAST21
Transmembranei178 – 198HelicalUniRule annotationAdd BLAST21
Transmembranei206 – 226HelicalUniRule annotationAdd BLAST21
Transmembranei262 – 282HelicalUniRule annotationAdd BLAST21
Transmembranei293 – 313HelicalUniRule annotationAdd BLAST21
Transmembranei315 – 335HelicalUniRule annotationAdd BLAST21
Transmembranei352 – 372HelicalUniRule annotationAdd BLAST21
Transmembranei384 – 404HelicalUniRule annotationAdd BLAST21
Transmembranei410 – 430HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000656681 – 554Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferaseAdd BLAST554

Interactioni

Protein-protein interaction databases

STRINGi393305.YE2188.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 83 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105SA9. Bacteria.
COG1807. LUCA.
HOGENOMiHOG000273002.
KOiK07264.
OMAiAWRIFRD.
OrthoDBiPOG091H00H0.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer. 1 hit.
InterProiView protein in InterPro
IPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39/83.
PfamiView protein in Pfam
PF02366. PMT. 1 hit.

Sequencei

Sequence statusi: Complete.

A1JPM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLKGSGAA LLALFFALVY LLPINSRLLW QPDETRYAEI SREMLQRGDW
60 70 80 90 100
VVPHLLGIRY FEKPIAGYWF NNISQWIFGD TNFAVRFGSI FSTALSAVFV
110 120 130 140 150
YWLATLLWRN RSTSFLAALI YLSMLLVFSI GSYAVLDPMI SLWLTASMVC
160 170 180 190 200
FYLTLRAETA KQKIGAYLLL GLACGMGFMT KGFLALAVPV ISVLPIVIQQ
210 220 230 240 250
KRVKELIIFG PIAIVGAVIL SLPWALAIAQ REPDFWHYFF WVEHIQRFAE
260 270 280 290 300
KDAQHKAPIW YYLPILCLGV LPWLGLLPAA LLKGWRERVA RPELFFLLSW
310 320 330 340 350
VLMPLIFFSV AKGKLPTYIL PCMAPLSLLM AAYATDCANK MHMRALKVNG
360 370 380 390 400
AINLIFGFIC ALAILVIGMG WVGHLVAYGP QEHQKVILAT IAFAGWGIVG
410 420 430 440 450
FATMRNNARH WHWAAACPLL FILLVGYLIP QQVIDSKQPQ NFIQNNFNEL
460 470 480 490 500
SSSRYVATDS VGVAAGLAWE LKRSDILMFS EKGELSYGLN YADSGDHYIS
510 520 530 540 550
AQDFSDWLVH ARQKGDVSLV IQLSRNEKIP DSLPAADKVS LMNRLALLWY

KKTP
Length:554
Mass (Da):62,340
Last modified:February 6, 2007 - v1
Checksum:i575C24AD2DAC040E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL12258.1.
RefSeqiWP_005169390.1. NC_008800.1.
YP_001006428.1. NC_008800.1.

Genome annotation databases

EnsemblBacteriaiCAL12258; CAL12258; YE2188.
GeneIDi4715461.
KEGGiyen:YE2188.
PATRICi18563986. VBIYerEnt11519_2353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL12258.1.
RefSeqiWP_005169390.1. NC_008800.1.
YP_001006428.1. NC_008800.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi393305.YE2188.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL12258; CAL12258; YE2188.
GeneIDi4715461.
KEGGiyen:YE2188.
PATRICi18563986. VBIYerEnt11519_2353.

Phylogenomic databases

eggNOGiENOG4105SA9. Bacteria.
COG1807. LUCA.
HOGENOMiHOG000273002.
KOiK07264.
OMAiAWRIFRD.
OrthoDBiPOG091H00H0.

Enzyme and pathway databases

UniPathwayiUPA00037.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer. 1 hit.
InterProiView protein in InterPro
IPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39/83.
PfamiView protein in Pfam
PF02366. PMT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARNT_YERE8
AccessioniPrimary (citable) accession number: A1JPM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: March 15, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.