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A1JPA1 (MDTK_YERE8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multidrug resistance protein MdtK
Alternative name(s):
Multidrug-efflux transporter
Gene names
Name:mdtK
Ordered Locus Names:YE2163
OrganismYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) [Complete proteome] [HAMAP]
Taxonomic identifier393305 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Multidrug efflux pump that functions probably as a Na+/drug antiporter By similarity. HAMAP-Rule MF_00400

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00400.

Sequence similarities

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. [View classification]

Ontologies

Keywords
   Biological processAntiport
Ion transport
Sodium transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processsodium ion transport

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionantiporter activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

drug transmembrane transporter activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Multidrug resistance protein MdtK HAMAP-Rule MF_00400
PRO_1000049615

Regions

Transmembrane11 – 3121Helical; Potential
Transmembrane46 – 6621Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane160 – 18021Helical; Potential
Transmembrane188 – 20821Helical; Potential
Transmembrane243 – 26321Helical; Potential
Transmembrane278 – 30023Helical; Potential
Transmembrane316 – 33621Helical; Potential
Transmembrane350 – 37021Helical; Potential
Transmembrane387 – 40721Helical; Potential
Transmembrane418 – 43821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1JPA1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 9A93F3511F3B6C5F

FASTA45749,437
        10         20         30         40         50         60 
MQKYIVEARS LLALAIPVVI AQLSQTAMGV VDTIMAGSVS ATDMAAVAVG TSIWLPAILF 

        70         80         90        100        110        120 
GHGLLLALTP TVAQLNGSGR RNQIAHQVRQ GFWLAFCVSV LIMVVIYNSD HIIMRMHNID 

       130        140        150        160        170        180 
PVLADKAVGF LHAIMWGAPG YLFFQVLRNQ CEGLSKTKPG MVIGFIGLLV NIPINYIFIY 

       190        200        210        220        230        240 
GKFGAPALGG VGCGVATGTV YWVMFLMMRW YVTRARSQQD IKLEKGFAAP DWQVMKRLGG 

       250        260        270        280        290        300 
LGLPVALALF FEVTLFAVVA LLVSPLGIVA VAGHQIALNF SSLMFMLPMS LSVAATIRVG 

       310        320        330        340        350        360 
FRLGQGSVDD ARVAAYTSIA VGLMLACVTA IFTVVFREHI ALLYNKTPEV VVMASHLMLL 

       370        380        390        400        410        420 
AALYQLSDAI QVIGSGVLRG YKDTRSIFFI TFTAYWLLGL PSGYLLGLTD YIVPAMGPSG 

       430        440        450 
FWIGFVIGLT SAAILMALRI RWLQKQPSAF ILQKAAH 

« Hide

References

[1]"The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081."
Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L., Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T., Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S., Sanders M., Whitehead S. expand/collapse author list , Quail M.A., Dougan G., Parkhill J., Prentice M.B.
PLoS Genet. 2:2039-2051(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 13174 / 8081.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM286415 Genomic DNA. Translation: CAL12233.1.
RefSeqYP_001006403.1. NC_008800.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING393305.YE2163.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL12233; CAL12233; YE2163.
GeneID4713482.
KEGGyen:YE2163.
PATRIC18563930. VBIYerEnt11519_2328.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0534.
HOGENOMHOG000038538.
KOK03327.
OMAGGVGCGW.
OrthoDBEOG6423C5.

Family and domain databases

HAMAPMF_00400. MdtK.
InterProIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsTIGR00797. matE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDTK_YERE8
AccessionPrimary (citable) accession number: A1JPA1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families