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Protein

Multidrug resistance protein MdtK

Gene

mdtK

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Multidrug efflux pump that functions probably as a Na+/drug antiporter.UniRule annotation

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-HAMAP
  2. drug transmembrane transporter activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtKUniRule annotation
Alternative name(s):
Multidrug-efflux transporterUniRule annotation
Gene namesi
Name:mdtKUniRule annotation
Ordered Locus Names:YE2163
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000642: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalUniRule annotationAdd
BLAST
Transmembranei46 – 6621HelicalUniRule annotationAdd
BLAST
Transmembranei93 – 11321HelicalUniRule annotationAdd
BLAST
Transmembranei127 – 14721HelicalUniRule annotationAdd
BLAST
Transmembranei160 – 18021HelicalUniRule annotationAdd
BLAST
Transmembranei188 – 20821HelicalUniRule annotationAdd
BLAST
Transmembranei243 – 26321HelicalUniRule annotationAdd
BLAST
Transmembranei278 – 30023HelicalUniRule annotationAdd
BLAST
Transmembranei316 – 33621HelicalUniRule annotationAdd
BLAST
Transmembranei350 – 37021HelicalUniRule annotationAdd
BLAST
Transmembranei387 – 40721HelicalUniRule annotationAdd
BLAST
Transmembranei418 – 43821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Multidrug resistance protein MdtKPRO_1000049615Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi393305.YE2163.

Family & Domainsi

Sequence similaritiesi

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000038538.
KOiK03327.
OMAiSIVFMLP.
OrthoDBiEOG6423C5.

Family and domain databases

HAMAPiMF_00400. MdtK.
InterProiIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A1JPA1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKYIVEARS LLALAIPVVI AQLSQTAMGV VDTIMAGSVS ATDMAAVAVG
60 70 80 90 100
TSIWLPAILF GHGLLLALTP TVAQLNGSGR RNQIAHQVRQ GFWLAFCVSV
110 120 130 140 150
LIMVVIYNSD HIIMRMHNID PVLADKAVGF LHAIMWGAPG YLFFQVLRNQ
160 170 180 190 200
CEGLSKTKPG MVIGFIGLLV NIPINYIFIY GKFGAPALGG VGCGVATGTV
210 220 230 240 250
YWVMFLMMRW YVTRARSQQD IKLEKGFAAP DWQVMKRLGG LGLPVALALF
260 270 280 290 300
FEVTLFAVVA LLVSPLGIVA VAGHQIALNF SSLMFMLPMS LSVAATIRVG
310 320 330 340 350
FRLGQGSVDD ARVAAYTSIA VGLMLACVTA IFTVVFREHI ALLYNKTPEV
360 370 380 390 400
VVMASHLMLL AALYQLSDAI QVIGSGVLRG YKDTRSIFFI TFTAYWLLGL
410 420 430 440 450
PSGYLLGLTD YIVPAMGPSG FWIGFVIGLT SAAILMALRI RWLQKQPSAF

ILQKAAH
Length:457
Mass (Da):49,437
Last modified:February 6, 2007 - v1
Checksum:i9A93F3511F3B6C5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL12233.1.
RefSeqiYP_001006403.1. NC_008800.1.

Genome annotation databases

EnsemblBacteriaiCAL12233; CAL12233; YE2163.
GeneIDi4713482.
KEGGiyen:YE2163.
PATRICi18563930. VBIYerEnt11519_2328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL12233.1.
RefSeqiYP_001006403.1. NC_008800.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi393305.YE2163.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL12233; CAL12233; YE2163.
GeneIDi4713482.
KEGGiyen:YE2163.
PATRICi18563930. VBIYerEnt11519_2328.

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000038538.
KOiK03327.
OMAiSIVFMLP.
OrthoDBiEOG6423C5.

Family and domain databases

HAMAPiMF_00400. MdtK.
InterProiIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 13174 / 8081.

Entry informationi

Entry nameiMDTK_YERE8
AccessioniPrimary (citable) accession number: A1JPA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: February 4, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.