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A1JMW5 (RLMI_YERE8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribosomal RNA large subunit methyltransferase I
EC=2.1.1.191
Alternative name(s):
23S rRNA m5C1962 methyltransferase
rRNA (cytosine-C(5)-)-methyltransferase RlmI
Gene names
Name:rlmI
Ordered Locus Names:YE1593
OrganismYersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) [Complete proteome] [HAMAP]
Taxonomic identifier393305 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia ›

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA By similarity. HAMAP-Rule MF_01857

Catalytic activity

S-adenosyl-L-methionine + cytosine(1962) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(1962) in 23S rRNA. HAMAP-Rule MF_01857

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_01857.

Sequence similarities

Belongs to the methyltransferase superfamily. RlmI family.

Contains 1 PUA domain.

Ontologies

Keywords
   Biological processrRNA processing
   Cellular componentCytoplasm
   LigandRNA-binding
S-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

rRNA (cytosine) methyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Ribosomal RNA large subunit methyltransferase I HAMAP-Rule MF_01857
PRO_0000366279

Regions

Domain1 – 7979PUA

Sequences

Sequence LengthMass (Da)Tools
A1JMW5 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: D8AF63B11E55A574

FASTA39444,327
        10         20         30         40         50         60 
MRLFLARGRE KSLLRRHPWI FSGAVQRLEG NASAGETIDI LDSQGKWLAR AAYSPESQIV 

        70         80         90        100        110        120 
ARVWTFQQDE VIDSEFFVRR LQQAQSWRDW LAQRDGLNGY RLIAGESDGL PGITIDRFQN 

       130        140        150        160        170        180 
FLVLQLLSAG AEHQRAALVS ALQQCYPECS IYDRSDVSVR KKEGLELTQG TVWGEMPPAL 

       190        200        210        220        230        240 
LPITEHGMKL LVDIQHGHKT GFYLDQRDSR LAARNYADGR RVLNCFSYTG AFAVAALMGN 

       250        260        270        280        290        300 
CQQVISVDTS QSVLDIAKQN VELNQLDLSK AEFIRDDVFQ LLRNYRAQGE KFDMIIMDPP 

       310        320        330        340        350        360 
KFVENKSQLA SACRGYKDIN MLAIQLLRPG GILLSFSCSG LMPTDLFQKI LADAALDAGH 

       370        380        390 
DIQFIEQFRQ AADHPVIATY PEGLYLKGFA CRIM

« Hide

References

[1]"The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081."
Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L., Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T., Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S., Sanders M., Whitehead S. expand/collapse author list , Quail M.A., Dougan G., Parkhill J., Prentice M.B.
PLoS Genet. 2:2039-2051(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 8081.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM286415 Genomic DNA. Translation: CAL11670.1.
RefSeqYP_001005886.1. NC_008800.1.

3D structure databases

ProteinModelPortalA1JMW5.
ModBaseSearch...

Protein-protein interaction databases

STRING393305.YE1593.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4714969.
KEGGyen:YE1593.
PATRIC18562706. VBIYerEnt11519_1723.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1092.
HOGENOMHOG000266009.
KOK06969.
OMACSGLMTT.
ProtClustDBPRK15128.

Family and domain databases

Gene3D2.30.130.10. 1 hit.
HAMAPMF_01857. 23SrRNA_methyltr_I.
InterProIPR002478. PUA.
IPR015947. PUA-like_domain.
IPR023542. rRNA_lsu_MeTfrase_I.
IPR019614. SAM-dep_methyl-trfase.
[Graphical view]
PfamPF10672. Methyltrans_SAM. 1 hit.
[Graphical view]
SMARTSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMSSF88697. PUA-like. 1 hit.
PROSITEPS50890. PUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRLMI_YERE8
AccessionPrimary (citable) accession number: A1JMW5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: February 6, 2007
Last modified: May 29, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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