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Protein

3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

Gene

fabA

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-2-decenoyl-ACP and then its isomerization to Z-3-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.UniRule annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation
(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] = trans-dec-2-enoyl-[acyl-carrier-protein] + H2O.UniRule annotation
Trans-dec-2-enoyl-[acyl-carrier-protein] = cis-dec-3-enoyl-[acyl-carrier-protein].UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei71UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Lyase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxydecanoyl-[acyl-carrier-protein] dehydrataseUniRule annotation (EC:4.2.1.59UniRule annotation)
Alternative name(s):
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabAUniRule annotation
Beta-hydroxydecanoyl thioester dehydraseUniRule annotation
Trans-2-decenoyl-[acyl-carrier-protein] isomeraseUniRule annotation (EC:5.3.3.14UniRule annotation)
Gene namesi
Name:fabAUniRule annotation
Ordered Locus Names:YE1578
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000642 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003018761 – 1723-hydroxydecanoyl-[acyl-carrier-protein] dehydrataseAdd BLAST172

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi393305.YE1578

Structurei

3D structure databases

ProteinModelPortaliA1JMS5
SMRiA1JMS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thioester dehydratase family. FabA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108RKI Bacteria
COG0764 LUCA
HOGENOMiHOG000277828
KOiK01716
OMAiFFDCHFK
OrthoDBiPOG091H0666

Family and domain databases

CDDicd01287 FabA, 1 hit
HAMAPiMF_00405 FabA, 1 hit
InterProiView protein in InterPro
IPR010083 FabA
IPR013114 FabA_FabZ
IPR029069 HotDog_dom_sf
PANTHERiPTHR30272:SF8 PTHR30272:SF8, 1 hit
PfamiView protein in Pfam
PF07977 FabA, 1 hit
SUPFAMiSSF54637 SSF54637, 1 hit
TIGRFAMsiTIGR01749 fabA, 1 hit

Sequencei

Sequence statusi: Complete.

A1JMS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDKRESYTK EDLEASGRGE LFGAGGPPLP AGNMLMMDRV VKMTEDGGTY
60 70 80 90 100
GKGYVEAELD INPDLWFFGC HFIGDPVMPG CLGLDAMWQL VGFYLGWLGG
110 120 130 140 150
EGKGRALGVG EVKFTGQVLP DAKKVTYRIN FKRIIMRKLI MGVADGEVLV
160 170
DGKVIYTATD LKVGLFKDTN AF
Length:172
Mass (Da):18,781
Last modified:February 6, 2007 - v1
Checksum:i2AF852BDDB93313D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA Translation: CAL11655.1
RefSeqiWP_005160035.1, NC_008800.1
YP_001005871.1, NC_008800.1

Genome annotation databases

EnsemblBacteriaiCAL11655; CAL11655; YE1578
GeneIDi4713272
KEGGiyen:YE1578
PATRICifig|393305.7.peg.1707

Entry informationi

Entry nameiFABA_YERE8
AccessioniPrimary (citable) accession number: A1JMS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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