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A1JMA3

- FTHS_YERE8

UniProt

A1JMA3 - FTHS_YERE8

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi74 – 818ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:YE1997
    OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
    Taxonomic identifieri393305 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000642: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 585585Formate--tetrahydrofolate ligasePRO_0000293073Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi393305.YE1997.

    Structurei

    3D structure databases

    ProteinModelPortaliA1JMA3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1JMA3-1 [UniParc]FASTAAdd to Basket

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    MTPTLSSSAD VLPSLSNMSS ETNLLPIQQI APQLGLSADD LIPYGHHMAK    50
    VDISALRPSG PQGKLILVSS ITPTPLGEGK TVTTIGLSQG INRLGYRGVA 100
    CIRQPSLGPV FGVKGGAAGG GAAQVLPMEK LNLHLTGDIH AISAAHNLAA 150
    AALDARLYHE QRLGAVFSQQ TGMPLLNIDA QQILWPRVVD HNDRALRHIQ 200
    VGVGGGTHGV ERHDHVEITA ASELMAILAL SESLHDMRQR IGRIILAHST 250
    SGQAITADDL GVAGAMTALM KETIHPTLMQ TSEQTPVLIH AGPFANIAHG 300
    NSSVLADRLG LQLADYVVTE AGFGSDMGME KFFNIKYRQS GITPSCVVLV 350
    ATLRSLKANS GVFDIKPGQP LPAEILNTNI PLLSQGCANL KWHINNAKSY 400
    GLPVVVAVNC FPDDSPEELA FLADYALSAG AIACEISEAF AKGGAGTTAL 450
    AQRVIDACAH ASPPVLAYPD NASLEQKIEI LAQRYGAREV TFTPQARQQL 500
    DSITAAGFGH LPLCIAKTPL SISADASLKN VPHDFVLPVT ACAVSAGAGF 550
    VRIYAGDIMT MPGLGTQPAY YHIDIDDEGC IRGLS 585
    Length:585
    Mass (Da):61,470
    Last modified:July 10, 2007 - v2
    Checksum:i3822C19C920B3175
    GO

    Sequence cautioni

    The sequence CAL12075.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM286415 Genomic DNA. Translation: CAL12075.1. Different initiation.
    RefSeqiYP_001006249.1. NC_008800.1.

    Genome annotation databases

    EnsemblBacteriaiCAL12075; CAL12075; YE1997.
    GeneIDi4715544.
    KEGGiyen:YE1997.
    PATRICi18563592. VBIYerEnt11519_2159.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM286415 Genomic DNA. Translation: CAL12075.1 . Different initiation.
    RefSeqi YP_001006249.1. NC_008800.1.

    3D structure databases

    ProteinModelPortali A1JMA3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 393305.YE1997.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL12075 ; CAL12075 ; YE1997 .
    GeneIDi 4715544.
    KEGGi yen:YE1997.
    PATRICi 18563592. VBIYerEnt11519_2159.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 13174 / 8081.

    Entry informationi

    Entry nameiFTHS_YERE8
    AccessioniPrimary (citable) accession number: A1JMA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 40 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3