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A1JMA3

- FTHS_YERE8

UniProt

A1JMA3 - FTHS_YERE8

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 818ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:YE1997
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000642: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Formate--tetrahydrofolate ligasePRO_0000293073Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi393305.YE1997.

Structurei

3D structure databases

ProteinModelPortaliA1JMA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1JMA3-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MTPTLSSSAD VLPSLSNMSS ETNLLPIQQI APQLGLSADD LIPYGHHMAK
60 70 80 90 100
VDISALRPSG PQGKLILVSS ITPTPLGEGK TVTTIGLSQG INRLGYRGVA
110 120 130 140 150
CIRQPSLGPV FGVKGGAAGG GAAQVLPMEK LNLHLTGDIH AISAAHNLAA
160 170 180 190 200
AALDARLYHE QRLGAVFSQQ TGMPLLNIDA QQILWPRVVD HNDRALRHIQ
210 220 230 240 250
VGVGGGTHGV ERHDHVEITA ASELMAILAL SESLHDMRQR IGRIILAHST
260 270 280 290 300
SGQAITADDL GVAGAMTALM KETIHPTLMQ TSEQTPVLIH AGPFANIAHG
310 320 330 340 350
NSSVLADRLG LQLADYVVTE AGFGSDMGME KFFNIKYRQS GITPSCVVLV
360 370 380 390 400
ATLRSLKANS GVFDIKPGQP LPAEILNTNI PLLSQGCANL KWHINNAKSY
410 420 430 440 450
GLPVVVAVNC FPDDSPEELA FLADYALSAG AIACEISEAF AKGGAGTTAL
460 470 480 490 500
AQRVIDACAH ASPPVLAYPD NASLEQKIEI LAQRYGAREV TFTPQARQQL
510 520 530 540 550
DSITAAGFGH LPLCIAKTPL SISADASLKN VPHDFVLPVT ACAVSAGAGF
560 570 580
VRIYAGDIMT MPGLGTQPAY YHIDIDDEGC IRGLS
Length:585
Mass (Da):61,470
Last modified:July 10, 2007 - v2
Checksum:i3822C19C920B3175
GO

Sequence cautioni

The sequence CAL12075.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL12075.1. Different initiation.
RefSeqiYP_001006249.1. NC_008800.1.

Genome annotation databases

EnsemblBacteriaiCAL12075; CAL12075; YE1997.
GeneIDi4715544.
KEGGiyen:YE1997.
PATRICi18563592. VBIYerEnt11519_2159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL12075.1 . Different initiation.
RefSeqi YP_001006249.1. NC_008800.1.

3D structure databases

ProteinModelPortali A1JMA3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 393305.YE1997.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL12075 ; CAL12075 ; YE1997 .
GeneIDi 4715544.
KEGGi yen:YE1997.
PATRICi 18563592. VBIYerEnt11519_2159.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 13174 / 8081.

Entry informationi

Entry nameiFTHS_YERE8
AccessioniPrimary (citable) accession number: A1JMA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: October 1, 2014
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3