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A1JMA3 (FTHS_YERE8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:YE1997
OrganismYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) [Complete proteome] [HAMAP]
Taxonomic identifier393305 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length585 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Sequence caution

The sequence CAL12075.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 585585Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000293073

Regions

Nucleotide binding74 – 818ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A1JMA3 [UniParc].

Last modified July 10, 2007. Version 2.
Checksum: 3822C19C920B3175

FASTA58561,470
        10         20         30         40         50         60 
MTPTLSSSAD VLPSLSNMSS ETNLLPIQQI APQLGLSADD LIPYGHHMAK VDISALRPSG 

        70         80         90        100        110        120 
PQGKLILVSS ITPTPLGEGK TVTTIGLSQG INRLGYRGVA CIRQPSLGPV FGVKGGAAGG 

       130        140        150        160        170        180 
GAAQVLPMEK LNLHLTGDIH AISAAHNLAA AALDARLYHE QRLGAVFSQQ TGMPLLNIDA 

       190        200        210        220        230        240 
QQILWPRVVD HNDRALRHIQ VGVGGGTHGV ERHDHVEITA ASELMAILAL SESLHDMRQR 

       250        260        270        280        290        300 
IGRIILAHST SGQAITADDL GVAGAMTALM KETIHPTLMQ TSEQTPVLIH AGPFANIAHG 

       310        320        330        340        350        360 
NSSVLADRLG LQLADYVVTE AGFGSDMGME KFFNIKYRQS GITPSCVVLV ATLRSLKANS 

       370        380        390        400        410        420 
GVFDIKPGQP LPAEILNTNI PLLSQGCANL KWHINNAKSY GLPVVVAVNC FPDDSPEELA 

       430        440        450        460        470        480 
FLADYALSAG AIACEISEAF AKGGAGTTAL AQRVIDACAH ASPPVLAYPD NASLEQKIEI 

       490        500        510        520        530        540 
LAQRYGAREV TFTPQARQQL DSITAAGFGH LPLCIAKTPL SISADASLKN VPHDFVLPVT 

       550        560        570        580 
ACAVSAGAGF VRIYAGDIMT MPGLGTQPAY YHIDIDDEGC IRGLS 

« Hide

References

[1]"The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081."
Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L., Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T., Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S., Sanders M., Whitehead S. expand/collapse author list , Quail M.A., Dougan G., Parkhill J., Prentice M.B.
PLoS Genet. 2:2039-2051(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 13174 / 8081.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM286415 Genomic DNA. Translation: CAL12075.1. Different initiation.
RefSeqYP_001006249.1. NC_008800.1.

3D structure databases

ProteinModelPortalA1JMA3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING393305.YE1997.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL12075; CAL12075; YE1997.
GeneID4715544.
KEGGyen:YE1997.
PATRIC18563592. VBIYerEnt11519_2159.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_YERE8
AccessionPrimary (citable) accession number: A1JMA3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: May 14, 2014
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways