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Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit NUniRule annotation
NDH-1 subunit NUniRule annotation
Gene namesi
Name:nuoNUniRule annotation
Ordered Locus Names:YE1356
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000642 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalUniRule annotationAdd BLAST21
Transmembranei35 – 55HelicalUniRule annotationAdd BLAST21
Transmembranei75 – 95HelicalUniRule annotationAdd BLAST21
Transmembranei104 – 124HelicalUniRule annotationAdd BLAST21
Transmembranei125 – 145HelicalUniRule annotationAdd BLAST21
Transmembranei159 – 179HelicalUniRule annotationAdd BLAST21
Transmembranei203 – 223HelicalUniRule annotationAdd BLAST21
Transmembranei235 – 255HelicalUniRule annotationAdd BLAST21
Transmembranei271 – 291HelicalUniRule annotationAdd BLAST21
Transmembranei297 – 317HelicalUniRule annotationAdd BLAST21
Transmembranei327 – 347HelicalUniRule annotationAdd BLAST21
Transmembranei374 – 394HelicalUniRule annotationAdd BLAST21
Transmembranei408 – 427HelicalUniRule annotationAdd BLAST20
Transmembranei449 – 469HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000173801 – 485NADH-quinone oxidoreductase subunit NAdd BLAST485

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi393305.YE1356.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CNR. Bacteria.
COG1007. LUCA.
HOGENOMiHOG000100796.
KOiK00343.
OMAiYALILMT.
OrthoDBiPOG091H0B2L.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1. 1 hit.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

A1JLL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITPQQLQA MLPLLIVGLT VVVVMLSIAW RRDHFINATL TVIGLNLALL
60 70 80 90 100
SLYFVGQVGP LDVTPLMRVD GYAMFYIGLV IVASLATSTF AYPWLNGYPD
110 120 130 140 150
NREEFYLLVL IATMGGILLA SANHLASLFL GIELISLPLF GLIGYAYRQK
160 170 180 190 200
RSLEASIKYM LLSAAASSFL LFGMALLYAE SGSLSFAGLG KSLSDSMIHQ
210 220 230 240 250
PLILAGLGMM IVGLGFKLSL VPFQLWTPDV YQGAPAPVST FLATASKIAI
260 270 280 290 300
FAVVMRLFLY APAADSEAVR LVLSLIAVAS ILFGNLMAIS QTNIKRLLGY
310 320 330 340 350
SSIAHLGYLL IALVAVQTHQ LALETAGVYL AGYLFSSLGA FGVVSLMSSP
360 370 380 390 400
YKGPDAESLF SYRGLFWHKP ILSAVMTVMM LSLAGIPMTL GFIGKFFVVA
410 420 430 440 450
MGVSANLWWL TGAVVLGSAI GLYYYLRVTV SLYLSAPETL VRDTPSNWAL
460 470 480
TAGGVVVLIS AILVLVLGIY PQPLISLVQL AQPLM
Length:485
Mass (Da):52,062
Last modified:February 6, 2007 - v1
Checksum:i90048C8FCB7B9F56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL11447.1.
RefSeqiWP_011815945.1. NC_008800.1.
YP_001005672.1. NC_008800.1.

Genome annotation databases

EnsemblBacteriaiCAL11447; CAL11447; YE1356.
GeneIDi4712724.
KEGGiyen:YE1356.
PATRICi18562204. VBIYerEnt11519_1475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL11447.1.
RefSeqiWP_011815945.1. NC_008800.1.
YP_001005672.1. NC_008800.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi393305.YE1356.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL11447; CAL11447; YE1356.
GeneIDi4712724.
KEGGiyen:YE1356.
PATRICi18562204. VBIYerEnt11519_1475.

Phylogenomic databases

eggNOGiENOG4105CNR. Bacteria.
COG1007. LUCA.
HOGENOMiHOG000100796.
KOiK00343.
OMAiYALILMT.
OrthoDBiPOG091H0B2L.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1. 1 hit.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNUON_YERE8
AccessioniPrimary (citable) accession number: A1JLL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.