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A1JLL1 (NUON_YERE8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit N

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit N
NDH-1 subunit N
Gene names
Name:nuoN
Ordered Locus Names:YE1356
OrganismYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) [Complete proteome] [HAMAP]
Taxonomic identifier393305 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_00445

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_00445

Subunit structure

NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00445.

Sequence similarities

Belongs to the complex I subunit 2 family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processATP synthesis coupled electron transport

Inferred from electronic annotation. Source: InterPro

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485NADH-quinone oxidoreductase subunit N HAMAP-Rule MF_00445
PRO_1000017380

Regions

Transmembrane10 – 3021Helical; Potential
Transmembrane35 – 5521Helical; Potential
Transmembrane75 – 9521Helical; Potential
Transmembrane104 – 12421Helical; Potential
Transmembrane125 – 14521Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane203 – 22321Helical; Potential
Transmembrane235 – 25521Helical; Potential
Transmembrane271 – 29121Helical; Potential
Transmembrane297 – 31721Helical; Potential
Transmembrane327 – 34721Helical; Potential
Transmembrane374 – 39421Helical; Potential
Transmembrane408 – 42720Helical; Potential
Transmembrane449 – 46921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1JLL1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 90048C8FCB7B9F56

FASTA48552,062
        10         20         30         40         50         60 
MTITPQQLQA MLPLLIVGLT VVVVMLSIAW RRDHFINATL TVIGLNLALL SLYFVGQVGP 

        70         80         90        100        110        120 
LDVTPLMRVD GYAMFYIGLV IVASLATSTF AYPWLNGYPD NREEFYLLVL IATMGGILLA 

       130        140        150        160        170        180 
SANHLASLFL GIELISLPLF GLIGYAYRQK RSLEASIKYM LLSAAASSFL LFGMALLYAE 

       190        200        210        220        230        240 
SGSLSFAGLG KSLSDSMIHQ PLILAGLGMM IVGLGFKLSL VPFQLWTPDV YQGAPAPVST 

       250        260        270        280        290        300 
FLATASKIAI FAVVMRLFLY APAADSEAVR LVLSLIAVAS ILFGNLMAIS QTNIKRLLGY 

       310        320        330        340        350        360 
SSIAHLGYLL IALVAVQTHQ LALETAGVYL AGYLFSSLGA FGVVSLMSSP YKGPDAESLF 

       370        380        390        400        410        420 
SYRGLFWHKP ILSAVMTVMM LSLAGIPMTL GFIGKFFVVA MGVSANLWWL TGAVVLGSAI 

       430        440        450        460        470        480 
GLYYYLRVTV SLYLSAPETL VRDTPSNWAL TAGGVVVLIS AILVLVLGIY PQPLISLVQL 


AQPLM 

« Hide

References

[1]"The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081."
Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L., Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T., Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S., Sanders M., Whitehead S. expand/collapse author list , Quail M.A., Dougan G., Parkhill J., Prentice M.B.
PLoS Genet. 2:2039-2051(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 13174 / 8081.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM286415 Genomic DNA. Translation: CAL11447.1.
RefSeqYP_001005672.1. NC_008800.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING393305.YE1356.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL11447; CAL11447; YE1356.
GeneID4712724.
KEGGyen:YE1356.
PATRIC18562204. VBIYerEnt11519_1475.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1007.
HOGENOMHOG000100796.
KOK00343.
OMASIVQLAM.
OrthoDBEOG64JFNZ.

Family and domain databases

HAMAPMF_00445. NDH1_NuoN_1.
InterProIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsTIGR01770. NDH_I_N. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNUON_YERE8
AccessionPrimary (citable) accession number: A1JLL1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families