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A1JJ29 (A1JJ29_YERE8) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length965 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner By similarity. HAMAP-Rule MF_02004 SAAS SAAS019499

Catalytic activity

ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). HAMAP-Rule MF_02004 SAAS SAAS019499

Subunit structure

Monomer By similarity. HAMAP-Rule MF_02004 SAAS SAAS019499

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_02004 SAAS SAAS019499.

Domain

The C-terminal coiled-coil domain is crucial for aminoacylation activity By similarity. HAMAP-Rule MF_02004

ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site By similarity. HAMAP-Rule MF_02004

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. HAMAP-Rule MF_02004

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Coiled coil896 – 96570 By similarity HAMAP-Rule MF_02004
Motif56 – 6611"HIGH" region By similarity HAMAP-Rule MF_02004
Motif568 – 5725"KMSKS" region By similarity HAMAP-Rule MF_02004

Sites

Binding site5711ATP By similarity HAMAP-Rule MF_02004

Sequences

Sequence LengthMass (Da)Tools
A1JJ29 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 605A163F5B96AEE6

FASTA965109,631
        10         20         30         40         50         60 
MENTPSNIDK TEPSLDKTYS PQEIEQPLYE HWEKQGYFKP NGDTSKESYC IMIPPPNVTG 

        70         80         90        100        110        120 
SLHMGHAFQQ TIMDTLIRYQ RMQGKNTLWQ AGTDHAGIAT QMVVERKIAA EEGKTRHDYG 

       130        140        150        160        170        180 
RDAFIDKIWQ WKGESGGTIT RQMRRLGNSV DWERERFTMD DGLSNAVKEV FVRLHKEDLI 

       190        200        210        220        230        240 
YRGKRLVNWD PKLRTAISDL EVENRESKGS MWHLRYPLAD GAKTADGKDY LVVATTRPET 

       250        260        270        280        290        300 
VLGDTGVAVN PEDPRYKDLI GKEVILPLVG RRIPILGDEH ADMEKGTGCV KITPAHDFND 

       310        320        330        340        350        360 
YEVGKRHALP MINILTFDGD IRSEAEVFDT NGEATDACSG AIPQQFQGLE RFAARKAVVA 

       370        380        390        400        410        420 
EFDKLGLLEE VKAHDLTVPY GDRGGVVIEP MLTDQWYVRT APLAKVAIEA VENGEIQFVP 

       430        440        450        460        470        480 
KQYENMYYSW MRDIQDWCIS RQLWWGHRIP AWYDEQGKVY VGRDEAEVRR ENNLGADVAL 

       490        500        510        520        530        540 
RQDEDVLDTW FSSGLWTFST LGWPEQTEAL KTFHPTSVVV SGFDIIFFWI ARMIMLTMHF 

       550        560        570        580        590        600 
MKDENGKPQV PFKTVYMTGL IRDDEGQKMS KSKGNVIDPL DMVDGISLEE LLEKRTGNMM 

       610        620        630        640        650        660 
QPQLAEKIRK RTEKQFPNGI EPHGTDALRF TLAALASTGR DINWDMKRLE GYRNFCNKLW 

       670        680        690        700        710        720 
NASRFVLMNT EGQDCGQNGG EMVLSLADRW ILAEFNQTIK AYREAMDTYR FDLAANILYE 

       730        740        750        760        770        780 
FTWNQFCDWY LELAKPVMNS GSEAELRGTR HTLIEVLEAL LRLAHPIIPY ITETIWQRVK 

       790        800        810        820        830        840 
TLKGITADTI MLQPFPEYDA SQVDEKALSD LEWIKQTIIA VRNIRAEMNI APGKPLEVML 

       850        860        870        880        890        900 
RGANAEAQRR VLENQSFIQS LARLSSLTLL PEGDKGPVSV TKLVEGAEVL IPMAGLIDKA 

       910        920        930        940        950        960 
TELERLAKEV AKLEAEIERI EGKLSNEGFV ARAPEAVVAK ERERMAACAE AKQKLIEQQA 


TIAAL

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References

[1]"The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081."
Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L., Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T., Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S., Sanders M., Whitehead S. expand/collapse author list , Quail M.A., Dougan G., Parkhill J., Prentice M.B.
PLoS Genet. 2:e206-e206(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 8081 EMBL CAL10618.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM286415 Genomic DNA. Translation: CAL10618.1.
RefSeqYP_001004862.1. NC_008800.1.

3D structure databases

ProteinModelPortalA1JJ29.
ModBaseSearch...

Protein-protein interaction databases

STRING393305.YE0498.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4715967.
KEGGyen:YE0498.
PATRIC18560402. VBIYerEnt11519_0592.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0525.
HOGENOMHOG000020094.
KOK01873.
OMAIMDALIR.
ProtClustDBPRK05729.

Family and domain databases

Gene3D1.10.287.380. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_02004. Val_tRNA_synth_type1.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR014729. Rossmann-like_a/b/a_fold.
IPR010978. tRNA-bd_arm.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR019499. Val-tRNA_synth_tRNA-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PANTHERPTHR11946:SF5. PTHR11946:SF5. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF10458. Val_tRNA-synt_C. 1 hit.
[Graphical view]
PRINTSPR00986. TRNASYNTHVAL.
SUPFAMSSF46589. tRNA_binding_arm. 1 hit.
SSF47323. tRNAsyn_1a_bind. 1 hit.
SSF50677. ValRS_IleRS_edit. 1 hit.
TIGRFAMsTIGR00422. valS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1JJ29_YERE8
AccessionPrimary (citable) accession number: A1JJ29
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: May 1, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info