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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei52UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:YE0404
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000642 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000683731 – 212Peptide methionine sulfoxide reductase MsrAAdd BLAST212

Interactioni

Protein-protein interaction databases

STRINGi393305.YE0404.

Structurei

3D structure databases

ProteinModelPortaliA1JIU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXP. Bacteria.
COG0225. LUCA.
HOGENOMiHOG000263862.
KOiK07304.
OMAiMVLRSEI.
OrthoDBiPOG091H059H.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

A1JIU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNFDKTAVI DAANALPGRL TPMPVATLHV VNGHSMTHVP EGMEVAIFAM
60 70 80 90 100
GCFWGVERLF WQQPGVYSTA AGYSGGYTPN PTYHEVCSGR TAHAEVVRVV
110 120 130 140 150
FDPAIISYKQ LLQIFWENHD PAQGMRQGGD VGTQYRSAIY VLTPEQETQA
160 170 180 190 200
QESQALFQQA MTKAGDSRAI TSEIAAALPF YYAEDDHQQY LYKNPQGYCG
210
LGGIGVCMPP NL
Length:212
Mass (Da):23,254
Last modified:February 6, 2007 - v1
Checksum:i234270E6C3555C88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL10531.1.
RefSeqiWP_005175425.1. NC_008800.1.
YP_001004777.1. NC_008800.1.

Genome annotation databases

EnsemblBacteriaiCAL10531; CAL10531; YE0404.
GeneIDi4713112.
KEGGiyen:YE0404.
PATRICi18560212. VBIYerEnt11519_0499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA. Translation: CAL10531.1.
RefSeqiWP_005175425.1. NC_008800.1.
YP_001004777.1. NC_008800.1.

3D structure databases

ProteinModelPortaliA1JIU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi393305.YE0404.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL10531; CAL10531; YE0404.
GeneIDi4713112.
KEGGiyen:YE0404.
PATRICi18560212. VBIYerEnt11519_0499.

Phylogenomic databases

eggNOGiENOG4107QXP. Bacteria.
COG0225. LUCA.
HOGENOMiHOG000263862.
KOiK07304.
OMAiMVLRSEI.
OrthoDBiPOG091H059H.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSRA_YERE8
AccessioniPrimary (citable) accession number: A1JIU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.