ID   A1JI87_YERE8            Unreviewed;       848 AA.
AC   A1JI87;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420, ECO:0000256|RuleBase:RU000604};
DE            EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201, ECO:0000256|RuleBase:RU000604};
GN   Name=cyaA {ECO:0000313|EMBL:CAL10325.1};
GN   Synonyms=cya {ECO:0000313|EMBL:CAL10325.1};
GN   OrderedLocusNames=YE0189 {ECO:0000313|EMBL:CAL10325.1};
OS   Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS   8081).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=393305 {ECO:0000313|EMBL:CAL10325.1, ECO:0000313|Proteomes:UP000000642};
RN   [1] {ECO:0000313|EMBL:CAL10325.1, ECO:0000313|Proteomes:UP000000642}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 13174 / 8081 {ECO:0000313|Proteomes:UP000000642};
RX   PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA   Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA   Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA   Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA   Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA   Prentice M.B.;
RT   "The complete genome sequence and comparative genome analysis of the high
RT   pathogenicity Yersinia enterocolitica strain 8081.";
RL   PLoS Genet. 2:2039-2051(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001593,
CC         ECO:0000256|RuleBase:RU000604};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU000604}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000256|ARBA:ARBA00007901, ECO:0000256|RuleBase:RU004184}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM286415; CAL10325.1; -; Genomic_DNA.
DR   RefSeq; WP_011815339.1; NC_008800.1.
DR   RefSeq; YP_001004577.1; NC_008800.1.
DR   AlphaFoldDB; A1JI87; -.
DR   KEGG; yen:YE0189; -.
DR   PATRIC; fig|393305.7.peg.279; -.
DR   eggNOG; COG3072; Bacteria.
DR   HOGENOM; CLU_013280_0_0_6; -.
DR   OrthoDB; 5571448at2; -.
DR   Proteomes; UP000000642; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   PANTHER; PTHR38760; ADENYLATE CYCLASE; 1.
DR   PANTHER; PTHR38760:SF1; ADENYLATE CYCLASE; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
DR   PROSITE; PS01093; ADENYLATE_CYCLASE_1_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998,
KW   ECO:0000256|RuleBase:RU000604}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000604};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          5..200
FT                   /note="Adenylate cyclase class-I N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12633"
SQ   SEQUENCE   848 AA;  96806 MW;  808D9CCE604C9527 CRC64;
     MYLYIETLKQ RLDAINQLRV DRALAAMGPA FQKVYSLLPT LLHCHHPLMP GYLDGNVPHG
     ICLFTPNETQ QDYLSEVEAK WGQPLQQSVG GELPITGVYS MGSTSSIGQC HTSDLDIWVC
     HQAWLDAEER NRLQKKCSLL EKWAASMGVE VSFFLIDENR FRHNASGSLG GEDCGSTQHI
     LLLDEFYRSA VRLAGKRILW NMVPVEEENN YDDYVLSLYA QGVLTPNEWL DLGGLSTLSA
     EEYFGASLWQ LYKSIDSPYK AVLKTVLLEA YSWEYPNSQL LAMEIKQRLH AGEIVAFGLD
     AYCMMLDRVT RYLTQINDTT RLNLVRRCFY LKVCEKLSRT PASVGWRREI LSQLVSEWGW
     SDESLAVLDN RANWKIERVR EAHNELLDAM MQSYRNLIRF ARRNNLSVSA SPQDIGVLTR
     KLYAAFEALP GKVTLVNPQI SPDLSEEHLT FIHVPAGRAN RPGWYLYNQA PSMETIVSHQ
     PLEYNRYLNK LVSWAYFNGL LTSKTHLHIK SANLCDTVKL QELVTDISHH FPLRLPAPTP
     KALYSPCEIR HLAIIVNLEH DPTAAFRNQV VHFDFRKLDV FSFGEQQQCL VGSIDLLYRN
     SWNEVRTLHF SGEQAVLEAL KTILGKMHQD AAPPESVDVF CYSQHLRGLI RTRIQQLVSE
     CIELRLSSTR QEPGRFKAVR VAGQTWGLFF ERLSVSVQKL ENAIEFYGAI SNNKLHGLSI
     QVETDQIHLP PVVDGFASEG IIQFFFEGTA DEKGFNIYIL DETNRVEVYH HCEGSKEELV
     RDVSRFYSSS HDRFTYGSSF INFNLPQFYQ IVQLDGRTQV IPFRSNALSH LHIADKETSA
     PAQQFQLH
//