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A1JI66 (GPPA_YERE8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:YE0165
OrganismYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) [Complete proteome] [HAMAP]
Taxonomic identifier393305 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_0000314502

Sequences

Sequence LengthMass (Da)Tools
A1JI66 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 70ADAE6AEAC437EC

FASTA49855,934
        10         20         30         40         50         60 
MMLSSTSLYA AIDLGSNSFH MLVVREVAGS IQTLARIKRK VRLAAGLDTQ NHLSQEAMER 

        70         80         90        100        110        120 
GWQCLKLFSE RLQDIPLDQI RVVATATLRL ASNAEEFLQT ATEILGCPIQ VISGEEEARL 

       130        140        150        160        170        180 
IYHGVAHTTG GPEQRLVVDI GGGSTELVTG NGAQANILVS LPMGCVTWLE RYFSDRNLAK 

       190        200        210        220        230        240 
DNFDRSESAA REMLKPVAQR FREHGWQICV GASGTVQALQ EIMVAQGMDE LITLAKLQQL 

       250        260        270        280        290        300 
KQRAIQCGKL EELEIPGLTL ERALVFPSGL SILIAIFQEL AIESMTLAGG ALREGLVYGM 

       310        320        330        340        350        360 
LHLPVEQDIR SRTVRNIQRR YLLDTEQAKR VSKLADNFLL QVEKEWRLDS RCRELLQNAC 

       370        380        390        400        410        420 
LIHEIGLSID FKRAPQHAAY LIRNLDLPGF TPAQKLLLAA LLQNQSDTLD LSLLNQQNAL 

       430        440        450        460        470        480 
PVDMAQHLCR LLRLAIIFSS RRRDDTLPAV RLRANGETLY VLLPHGWLQQ HPYRAEALEQ 

       490 
ESHWQSYVQW PLLLEEFN 

« Hide

References

[1]"The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081."
Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L., Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T., Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S., Sanders M., Whitehead S. expand/collapse author list , Quail M.A., Dougan G., Parkhill J., Prentice M.B.
PLoS Genet. 2:2039-2051(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 13174 / 8081.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM286415 Genomic DNA. Translation: CAL10304.1.
RefSeqYP_001004556.1. NC_008800.1.

3D structure databases

ProteinModelPortalA1JI66.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING393305.YE0165.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL10304; CAL10304; YE0165.
GeneID4714873.
KEGGyen:YE0165.
PATRIC18559685. VBIYerEnt11519_0256.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMASYVHWAL.
OrthoDBEOG6M6JN6.

Enzyme and pathway databases

UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsTIGR03706. exo_poly_only. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGPPA_YERE8
AccessionPrimary (citable) accession number: A1JI66
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways