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A1JI66

- GPPA_YERE8

UniProt

A1JI66 - GPPA_YERE8

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Protein
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
Gene
gppA, YE0165
Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. exopolyphosphatase activity Source: InterPro
  2. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
  3. polyphosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:YE0165
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000642: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation
PRO_0000314502Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi393305.YE0165.

Structurei

3D structure databases

ProteinModelPortaliA1JI66.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiSYVHWAL.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

Sequencei

Sequence statusi: Complete.

A1JI66-1 [UniParc]FASTAAdd to Basket

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MMLSSTSLYA AIDLGSNSFH MLVVREVAGS IQTLARIKRK VRLAAGLDTQ    50
NHLSQEAMER GWQCLKLFSE RLQDIPLDQI RVVATATLRL ASNAEEFLQT 100
ATEILGCPIQ VISGEEEARL IYHGVAHTTG GPEQRLVVDI GGGSTELVTG 150
NGAQANILVS LPMGCVTWLE RYFSDRNLAK DNFDRSESAA REMLKPVAQR 200
FREHGWQICV GASGTVQALQ EIMVAQGMDE LITLAKLQQL KQRAIQCGKL 250
EELEIPGLTL ERALVFPSGL SILIAIFQEL AIESMTLAGG ALREGLVYGM 300
LHLPVEQDIR SRTVRNIQRR YLLDTEQAKR VSKLADNFLL QVEKEWRLDS 350
RCRELLQNAC LIHEIGLSID FKRAPQHAAY LIRNLDLPGF TPAQKLLLAA 400
LLQNQSDTLD LSLLNQQNAL PVDMAQHLCR LLRLAIIFSS RRRDDTLPAV 450
RLRANGETLY VLLPHGWLQQ HPYRAEALEQ ESHWQSYVQW PLLLEEFN 498
Length:498
Mass (Da):55,934
Last modified:February 6, 2007 - v1
Checksum:i70ADAE6AEAC437EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286415 Genomic DNA. Translation: CAL10304.1.
RefSeqiYP_001004556.1. NC_008800.1.

Genome annotation databases

EnsemblBacteriaiCAL10304; CAL10304; YE0165.
GeneIDi4714873.
KEGGiyen:YE0165.
PATRICi18559685. VBIYerEnt11519_0256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM286415 Genomic DNA. Translation: CAL10304.1 .
RefSeqi YP_001004556.1. NC_008800.1.

3D structure databases

ProteinModelPortali A1JI66.
ModBasei Search...

Protein-protein interaction databases

STRINGi 393305.YE0165.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL10304 ; CAL10304 ; YE0165 .
GeneIDi 4714873.
KEGGi yen:YE0165.
PATRICi 18559685. VBIYerEnt11519_0256.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi SYVHWAL.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03706. exo_poly_only. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 13174 / 8081.

Entry informationi

Entry nameiGPPA_YERE8
AccessioniPrimary (citable) accession number: A1JI66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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