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A1JHW9

- SLMA_YERE8

UniProt

A1JHW9 - SLMA_YERE8

Protein

Nucleoid occlusion factor SlmA

Gene

slmA

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi33 – 5220H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. negative regulation of barrier septum assembly Source: InterPro

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoid occlusion factor SlmAUniRule annotation
    Gene namesi
    Name:slmAUniRule annotation
    Ordered Locus Names:YE0060
    OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
    Taxonomic identifieri393305 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000642: Chromosome

    Subcellular locationi

    Cytoplasmnucleoid UniRule annotation

    GO - Cellular componenti

    1. bacterial nucleoid Source: UniProtKB-HAMAP
    2. cytoplasm Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Nucleoid occlusion factor SlmAPRO_1000070538Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer. Interacts with FtsZ.UniRule annotation

    Protein-protein interaction databases

    STRINGi393305.YE0060.

    Structurei

    3D structure databases

    ProteinModelPortaliA1JHW9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 7062HTH tetR-typeUniRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili119 – 14426UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the nucleoid occlusion factor SlmA family.UniRule annotation
    Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG1309.
    HOGENOMiHOG000266053.
    KOiK05501.
    OMAiEKDTSAR.
    OrthoDBiEOG6G7R3C.

    Family and domain databases

    Gene3Di1.10.357.10. 1 hit.
    HAMAPiMF_01839. NO_factor_SlmA.
    InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
    IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR023769. NO_SlmA.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view]
    PfamiPF00440. TetR_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEiPS01081. HTH_TETR_1. 1 hit.
    PS50977. HTH_TETR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1JHW9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEKENTKRN RREEILQALA QMLESSDGSQ RITTAKLAAN VGVSEAALYR    50
    HFPSKTRMFD SLIEFIEDSL MSRINLILQD EKETFNRLRL ILLLVLGFAE 100
    RNPGLTRIMT GHALMFEQDR LQGRINQLFE RIEVQLRQVL REKKLRDGQG 150
    FIHDEALLAT QLLAFCEGML SRFVRSEFRY RPTQEFDARW PLIVAQLQ 198
    Length:198
    Mass (Da):23,112
    Last modified:February 6, 2007 - v1
    Checksum:i8A147A9A9CAE5785
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM286415 Genomic DNA. Translation: CAL10202.1.
    RefSeqiYP_001004454.1. NC_008800.1.

    Genome annotation databases

    EnsemblBacteriaiCAL10202; CAL10202; YE0060.
    GeneIDi4715151.
    KEGGiyen:YE0060.
    PATRICi18559455. VBIYerEnt11519_0148.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM286415 Genomic DNA. Translation: CAL10202.1 .
    RefSeqi YP_001004454.1. NC_008800.1.

    3D structure databases

    ProteinModelPortali A1JHW9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 393305.YE0060.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL10202 ; CAL10202 ; YE0060 .
    GeneIDi 4715151.
    KEGGi yen:YE0060.
    PATRICi 18559455. VBIYerEnt11519_0148.

    Phylogenomic databases

    eggNOGi COG1309.
    HOGENOMi HOG000266053.
    KOi K05501.
    OMAi EKDTSAR.
    OrthoDBi EOG6G7R3C.

    Family and domain databases

    Gene3Di 1.10.357.10. 1 hit.
    HAMAPi MF_01839. NO_factor_SlmA.
    InterProi IPR023772. DNA-bd_HTH_TetR-type_CS.
    IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR023769. NO_SlmA.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view ]
    Pfami PF00440. TetR_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEi PS01081. HTH_TETR_1. 1 hit.
    PS50977. HTH_TETR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 13174 / 8081.

    Entry informationi

    Entry nameiSLMA_YERE8
    AccessioniPrimary (citable) accession number: A1JHW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3