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Protein

Nucleoid occlusion factor SlmA

Gene

slmA

Organism
Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 52H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoid occlusion factor SlmAUniRule annotation
Gene namesi
Name:slmAUniRule annotation
Ordered Locus Names:YE0060
OrganismiYersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
Taxonomic identifieri393305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000642 Componenti: Chromosome

Subcellular locationi

  • nucleoid UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000705381 – 198Nucleoid occlusion factor SlmAAdd BLAST198

Interactioni

Subunit structurei

Homodimer. Interacts with FtsZ.UniRule annotation

Protein-protein interaction databases

STRINGi393305.YE0060

Structurei

3D structure databases

ProteinModelPortaliA1JHW9
SMRiA1JHW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 70HTH tetR-typeUniRule annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili119 – 144UniRule annotationAdd BLAST26

Sequence similaritiesi

Belongs to the nucleoid occlusion factor SlmA family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4105EC0 Bacteria
COG1309 LUCA
HOGENOMiHOG000266053
KOiK05501
OMAiIEQTVFG
OrthoDBiPOG091H068M

Family and domain databases

HAMAPiMF_01839 NO_factor_SlmA, 1 hit
InterProiView protein in InterPro
IPR023772 DNA-bd_HTH_TetR-type_CS
IPR009057 Homeobox-like_sf
IPR001647 HTH_TetR
IPR023769 NO_SlmA
IPR036271 Tet_transcr_reg_TetR-rel_C_sf
PfamiView protein in Pfam
PF00440 TetR_N, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF48498 SSF48498, 1 hit
PROSITEiView protein in PROSITE
PS01081 HTH_TETR_1, 1 hit
PS50977 HTH_TETR_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1JHW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKENTKRN RREEILQALA QMLESSDGSQ RITTAKLAAN VGVSEAALYR
60 70 80 90 100
HFPSKTRMFD SLIEFIEDSL MSRINLILQD EKETFNRLRL ILLLVLGFAE
110 120 130 140 150
RNPGLTRIMT GHALMFEQDR LQGRINQLFE RIEVQLRQVL REKKLRDGQG
160 170 180 190
FIHDEALLAT QLLAFCEGML SRFVRSEFRY RPTQEFDARW PLIVAQLQ
Length:198
Mass (Da):23,112
Last modified:February 6, 2007 - v1
Checksum:i8A147A9A9CAE5785
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM286415 Genomic DNA Translation: CAL10202.1
RefSeqiWP_004714376.1, NC_008800.1
YP_001004454.1, NC_008800.1

Genome annotation databases

EnsemblBacteriaiCAL10202; CAL10202; YE0060
GeneIDi4715151
KEGGiyen:YE0060
PATRICifig|393305.7.peg.148

Similar proteinsi

Entry informationi

Entry nameiSLMA_YERE8
AccessioniPrimary (citable) accession number: A1JHW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health