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A1IGU5

- ARH37_HUMAN

UniProt

A1IGU5 - ARH37_HUMAN

Protein

Rho guanine nucleotide exchange factor 37

Gene

ARHGEF37

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    May act as a guanine nucleotide exchange factor (GEF).By similarity

    GO - Molecular functioni

    1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho guanine nucleotide exchange factor 37
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:34430. ARHGEF37.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165660135.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 675675Rho guanine nucleotide exchange factor 37PRO_0000337050Add
    BLAST

    Proteomic databases

    MaxQBiA1IGU5.
    PaxDbiA1IGU5.
    PRIDEiA1IGU5.

    PTM databases

    PhosphoSiteiA1IGU5.

    Expressioni

    Gene expression databases

    ArrayExpressiA1IGU5.
    BgeeiA1IGU5.
    GenevestigatoriA1IGU5.

    Organism-specific databases

    HPAiHPA043885.

    Structurei

    3D structure databases

    ProteinModelPortaliA1IGU5.
    SMRiA1IGU5. Positions 24-252, 504-568, 605-662.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 213184DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini254 – 455202BARPROSITE-ProRule annotationAdd
    BLAST
    Domaini506 – 56964SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini602 – 66564SH3 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BAR domain.PROSITE-ProRule annotation
    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 2 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG325944.
    HOGENOMiHOG000155522.
    HOVERGENiHBG103401.
    InParanoidiA1IGU5.
    OMAiVYKVYCA.
    OrthoDBiEOG7M3J14.
    PhylomeDBiA1IGU5.
    TreeFamiTF330015.

    Family and domain databases

    Gene3Di1.20.1270.60. 1 hit.
    1.20.900.10. 1 hit.
    InterProiIPR027267. AH/BAR-dom.
    IPR004148. BAR_dom.
    IPR000219. DH-domain.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF03114. BAR. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF00018. SH3_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    SMARTiSM00325. RhoGEF. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 2 hits.
    PROSITEiPS51021. BAR. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1IGU5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKHGADEPS SRSGSPDREG RASEDRSLLH QRLAVRELID TEVSYLHMLQ    50
    LCASDIRSRL QQLPQGDLDV LFSNIDDIIK VNSRFLHDLQ ETASKEEEQV 100
    QLVGNIFLEF QEELEQVYKV YCASYDQALL LVDTYRKEPE LQRHIQGIVE 150
    AVVPQAGSSG LSFLLVIPLQ RITRYPLLLQ KILENTVPDA SAYPVLQRAV 200
    SALQDVNTNI NEYKMRKEVA SKYTKVEQLT LRERLARINT HTLSKKTTRL 250
    SQLLKQEAGL IPRTEDKEFD DLEERFQWVS LCVTELKNNV AAYLDNLQAF 300
    LYFRPHEYNL DIPEGPAVQY CNLARDLHLE AFLKFKQRLE GLVWQPLCSL 350
    AKALLGPQNL IKKRLDKLLD FERVEEKLLE VGSVTYQEEA ARHTYQALNS 400
    LLVAELPQFN QLVMQWLGQI MCTFVTLQRD LAKQVLQRAE GSMAQLPHHH 450
    VPEPAFRKLV EDALGRTSNQ LRSFQETFEK VQPPPTTQPL LPGSERQVQA 500
    LLSRYGPGKL YQVTSNISGT GTLDLTLPRG QIVAILQNKD TKGNSGRWLV 550
    DTGGHRGYVP AGKLQLYHVV PSAEELRRQA GLNKDPRCLT PEPSPALVPS 600
    IPTMNQVIAA YPFVARSSHE VSLQAGQPVT ILEAQDKKGN PEWSLVEVNG 650
    QRGYVPSGFL ARARSPVLWG WSLPS 675
    Length:675
    Mass (Da):76,278
    Last modified:May 20, 2008 - v2
    Checksum:i90EC3F5B7BFA7178
    GO

    Sequence cautioni

    The sequence BAC85655.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti421 – 4211M → L.
    Corresponds to variant rs4629585 [ dbSNP | Ensembl ].
    VAR_043579
    Natural varianti489 – 4891P → L.1 Publication
    Corresponds to variant rs9324624 [ dbSNP | Ensembl ].
    VAR_043580
    Natural varianti518 – 5181S → R.
    Corresponds to variant rs7732714 [ dbSNP | Ensembl ].
    VAR_043581
    Natural varianti586 – 5861P → T.
    Corresponds to variant rs3733662 [ dbSNP | Ensembl ].
    VAR_043582
    Natural varianti604 – 6041M → V.1 Publication
    Corresponds to variant rs1135093 [ dbSNP | Ensembl ].
    VAR_043583

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB199796 mRNA. Translation: BAF43710.1.
    AK123597 mRNA. Translation: BAC85655.1. Different initiation.
    CCDSiCCDS43385.1.
    RefSeqiNP_001001669.2. NM_001001669.2.
    XP_005268504.1. XM_005268447.2.
    XP_006714847.1. XM_006714784.1.
    UniGeneiHs.256206.

    Genome annotation databases

    EnsembliENST00000333677; ENSP00000328083; ENSG00000183111.
    GeneIDi389337.
    KEGGihsa:389337.
    UCSCiuc003lra.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB199796 mRNA. Translation: BAF43710.1 .
    AK123597 mRNA. Translation: BAC85655.1 . Different initiation.
    CCDSi CCDS43385.1.
    RefSeqi NP_001001669.2. NM_001001669.2.
    XP_005268504.1. XM_005268447.2.
    XP_006714847.1. XM_006714784.1.
    UniGenei Hs.256206.

    3D structure databases

    ProteinModelPortali A1IGU5.
    SMRi A1IGU5. Positions 24-252, 504-568, 605-662.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A1IGU5.

    Proteomic databases

    MaxQBi A1IGU5.
    PaxDbi A1IGU5.
    PRIDEi A1IGU5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333677 ; ENSP00000328083 ; ENSG00000183111 .
    GeneIDi 389337.
    KEGGi hsa:389337.
    UCSCi uc003lra.1. human.

    Organism-specific databases

    CTDi 389337.
    GeneCardsi GC05P148961.
    HGNCi HGNC:34430. ARHGEF37.
    HPAi HPA043885.
    neXtProti NX_A1IGU5.
    PharmGKBi PA165660135.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG325944.
    HOGENOMi HOG000155522.
    HOVERGENi HBG103401.
    InParanoidi A1IGU5.
    OMAi VYKVYCA.
    OrthoDBi EOG7M3J14.
    PhylomeDBi A1IGU5.
    TreeFami TF330015.

    Miscellaneous databases

    GenomeRNAii 389337.
    NextBioi 102796.
    PROi A1IGU5.

    Gene expression databases

    ArrayExpressi A1IGU5.
    Bgeei A1IGU5.
    Genevestigatori A1IGU5.

    Family and domain databases

    Gene3Di 1.20.1270.60. 1 hit.
    1.20.900.10. 1 hit.
    InterProi IPR027267. AH/BAR-dom.
    IPR004148. BAR_dom.
    IPR000219. DH-domain.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF03114. BAR. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF00018. SH3_1. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    SMARTi SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 2 hits.
    PROSITEi PS51021. BAR. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hypothetical proteins, rat 2-88 (Tuba 3) and its homologs of mouse and human."
      Yamazaki N.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 433-675, VARIANTS LEU-489 AND VAL-604.
      Tissue: Tongue.

    Entry informationi

    Entry nameiARH37_HUMAN
    AccessioniPrimary (citable) accession number: A1IGU5
    Secondary accession number(s): Q6ZW51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 61 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3