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A1IGU5

- ARH37_HUMAN

UniProt

A1IGU5 - ARH37_HUMAN

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Protein

Rho guanine nucleotide exchange factor 37

Gene
ARHGEF37
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

May act as a guanine nucleotide exchange factor (GEF) By similarity.

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 37
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:34430. ARHGEF37.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165660135.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 675675Rho guanine nucleotide exchange factor 37PRO_0000337050Add
BLAST

Proteomic databases

MaxQBiA1IGU5.
PaxDbiA1IGU5.
PRIDEiA1IGU5.

PTM databases

PhosphoSiteiA1IGU5.

Expressioni

Gene expression databases

ArrayExpressiA1IGU5.
BgeeiA1IGU5.
GenevestigatoriA1IGU5.

Organism-specific databases

HPAiHPA043885.

Structurei

3D structure databases

ProteinModelPortaliA1IGU5.
SMRiA1IGU5. Positions 24-252, 504-568, 605-662.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 213184DHAdd
BLAST
Domaini254 – 455202BARAdd
BLAST
Domaini506 – 56964SH3 1Add
BLAST
Domaini602 – 66564SH3 2Add
BLAST

Sequence similaritiesi

Contains 1 BAR domain.
Contains 2 SH3 domains.

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG325944.
HOGENOMiHOG000155522.
HOVERGENiHBG103401.
InParanoidiA1IGU5.
OMAiVYKVYCA.
OrthoDBiEOG7M3J14.
PhylomeDBiA1IGU5.
TreeFamiTF330015.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEiPS51021. BAR. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1IGU5-1 [UniParc]FASTAAdd to Basket

« Hide

MAKHGADEPS SRSGSPDREG RASEDRSLLH QRLAVRELID TEVSYLHMLQ    50
LCASDIRSRL QQLPQGDLDV LFSNIDDIIK VNSRFLHDLQ ETASKEEEQV 100
QLVGNIFLEF QEELEQVYKV YCASYDQALL LVDTYRKEPE LQRHIQGIVE 150
AVVPQAGSSG LSFLLVIPLQ RITRYPLLLQ KILENTVPDA SAYPVLQRAV 200
SALQDVNTNI NEYKMRKEVA SKYTKVEQLT LRERLARINT HTLSKKTTRL 250
SQLLKQEAGL IPRTEDKEFD DLEERFQWVS LCVTELKNNV AAYLDNLQAF 300
LYFRPHEYNL DIPEGPAVQY CNLARDLHLE AFLKFKQRLE GLVWQPLCSL 350
AKALLGPQNL IKKRLDKLLD FERVEEKLLE VGSVTYQEEA ARHTYQALNS 400
LLVAELPQFN QLVMQWLGQI MCTFVTLQRD LAKQVLQRAE GSMAQLPHHH 450
VPEPAFRKLV EDALGRTSNQ LRSFQETFEK VQPPPTTQPL LPGSERQVQA 500
LLSRYGPGKL YQVTSNISGT GTLDLTLPRG QIVAILQNKD TKGNSGRWLV 550
DTGGHRGYVP AGKLQLYHVV PSAEELRRQA GLNKDPRCLT PEPSPALVPS 600
IPTMNQVIAA YPFVARSSHE VSLQAGQPVT ILEAQDKKGN PEWSLVEVNG 650
QRGYVPSGFL ARARSPVLWG WSLPS 675
Length:675
Mass (Da):76,278
Last modified:May 20, 2008 - v2
Checksum:i90EC3F5B7BFA7178
GO

Sequence cautioni

The sequence BAC85655.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti421 – 4211M → L.
Corresponds to variant rs4629585 [ dbSNP | Ensembl ].
VAR_043579
Natural varianti489 – 4891P → L.1 Publication
Corresponds to variant rs9324624 [ dbSNP | Ensembl ].
VAR_043580
Natural varianti518 – 5181S → R.
Corresponds to variant rs7732714 [ dbSNP | Ensembl ].
VAR_043581
Natural varianti586 – 5861P → T.
Corresponds to variant rs3733662 [ dbSNP | Ensembl ].
VAR_043582
Natural varianti604 – 6041M → V.1 Publication
Corresponds to variant rs1135093 [ dbSNP | Ensembl ].
VAR_043583

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB199796 mRNA. Translation: BAF43710.1.
AK123597 mRNA. Translation: BAC85655.1. Different initiation.
CCDSiCCDS43385.1.
RefSeqiNP_001001669.2. NM_001001669.2.
XP_005268504.1. XM_005268447.2.
XP_006714847.1. XM_006714784.1.
UniGeneiHs.256206.

Genome annotation databases

EnsembliENST00000333677; ENSP00000328083; ENSG00000183111.
GeneIDi389337.
KEGGihsa:389337.
UCSCiuc003lra.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB199796 mRNA. Translation: BAF43710.1 .
AK123597 mRNA. Translation: BAC85655.1 . Different initiation.
CCDSi CCDS43385.1.
RefSeqi NP_001001669.2. NM_001001669.2.
XP_005268504.1. XM_005268447.2.
XP_006714847.1. XM_006714784.1.
UniGenei Hs.256206.

3D structure databases

ProteinModelPortali A1IGU5.
SMRi A1IGU5. Positions 24-252, 504-568, 605-662.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A1IGU5.

Proteomic databases

MaxQBi A1IGU5.
PaxDbi A1IGU5.
PRIDEi A1IGU5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333677 ; ENSP00000328083 ; ENSG00000183111 .
GeneIDi 389337.
KEGGi hsa:389337.
UCSCi uc003lra.1. human.

Organism-specific databases

CTDi 389337.
GeneCardsi GC05P148961.
HGNCi HGNC:34430. ARHGEF37.
HPAi HPA043885.
neXtProti NX_A1IGU5.
PharmGKBi PA165660135.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG325944.
HOGENOMi HOG000155522.
HOVERGENi HBG103401.
InParanoidi A1IGU5.
OMAi VYKVYCA.
OrthoDBi EOG7M3J14.
PhylomeDBi A1IGU5.
TreeFami TF330015.

Miscellaneous databases

GenomeRNAii 389337.
NextBioi 102796.
PROi A1IGU5.

Gene expression databases

ArrayExpressi A1IGU5.
Bgeei A1IGU5.
Genevestigatori A1IGU5.

Family and domain databases

Gene3Di 1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProi IPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF03114. BAR. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00325. RhoGEF. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEi PS51021. BAR. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Hypothetical proteins, rat 2-88 (Tuba 3) and its homologs of mouse and human."
    Yamazaki N.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 433-675, VARIANTS LEU-489 AND VAL-604.
    Tissue: Tongue.

Entry informationi

Entry nameiARH37_HUMAN
AccessioniPrimary (citable) accession number: A1IGU5
Secondary accession number(s): Q6ZW51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 9, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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