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A1IGU5 (ARH37_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho guanine nucleotide exchange factor 37
Gene names
Name:ARHGEF37
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length675 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a guanine nucleotide exchange factor (GEF) By similarity.

Sequence similarities

Contains 1 BAR domain.

Contains 1 DH (DBL-homology) domain.

Contains 2 SH3 domains.

Sequence caution

The sequence BAC85655.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainRepeat
SH3 domain
   Molecular functionGuanine-nucleotide releasing factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRho guanyl-nucleotide exchange factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 675675Rho guanine nucleotide exchange factor 37
PRO_0000337050

Regions

Domain30 – 213184DH
Domain254 – 455202BAR
Domain506 – 56964SH3 1
Domain602 – 66564SH3 2

Natural variations

Natural variant4211M → L.
Corresponds to variant rs4629585 [ dbSNP | Ensembl ].
VAR_043579
Natural variant4891P → L. Ref.2
Corresponds to variant rs9324624 [ dbSNP | Ensembl ].
VAR_043580
Natural variant5181S → R.
Corresponds to variant rs7732714 [ dbSNP | Ensembl ].
VAR_043581
Natural variant5861P → T.
Corresponds to variant rs3733662 [ dbSNP | Ensembl ].
VAR_043582
Natural variant6041M → V. Ref.2
Corresponds to variant rs1135093 [ dbSNP | Ensembl ].
VAR_043583

Sequences

Sequence LengthMass (Da)Tools
A1IGU5 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: 90EC3F5B7BFA7178

FASTA67576,278
        10         20         30         40         50         60 
MAKHGADEPS SRSGSPDREG RASEDRSLLH QRLAVRELID TEVSYLHMLQ LCASDIRSRL 

        70         80         90        100        110        120 
QQLPQGDLDV LFSNIDDIIK VNSRFLHDLQ ETASKEEEQV QLVGNIFLEF QEELEQVYKV 

       130        140        150        160        170        180 
YCASYDQALL LVDTYRKEPE LQRHIQGIVE AVVPQAGSSG LSFLLVIPLQ RITRYPLLLQ 

       190        200        210        220        230        240 
KILENTVPDA SAYPVLQRAV SALQDVNTNI NEYKMRKEVA SKYTKVEQLT LRERLARINT 

       250        260        270        280        290        300 
HTLSKKTTRL SQLLKQEAGL IPRTEDKEFD DLEERFQWVS LCVTELKNNV AAYLDNLQAF 

       310        320        330        340        350        360 
LYFRPHEYNL DIPEGPAVQY CNLARDLHLE AFLKFKQRLE GLVWQPLCSL AKALLGPQNL 

       370        380        390        400        410        420 
IKKRLDKLLD FERVEEKLLE VGSVTYQEEA ARHTYQALNS LLVAELPQFN QLVMQWLGQI 

       430        440        450        460        470        480 
MCTFVTLQRD LAKQVLQRAE GSMAQLPHHH VPEPAFRKLV EDALGRTSNQ LRSFQETFEK 

       490        500        510        520        530        540 
VQPPPTTQPL LPGSERQVQA LLSRYGPGKL YQVTSNISGT GTLDLTLPRG QIVAILQNKD 

       550        560        570        580        590        600 
TKGNSGRWLV DTGGHRGYVP AGKLQLYHVV PSAEELRRQA GLNKDPRCLT PEPSPALVPS 

       610        620        630        640        650        660 
IPTMNQVIAA YPFVARSSHE VSLQAGQPVT ILEAQDKKGN PEWSLVEVNG QRGYVPSGFL 

       670 
ARARSPVLWG WSLPS 

« Hide

References

« Hide 'large scale' references
[1]"Hypothetical proteins, rat 2-88 (Tuba 3) and its homologs of mouse and human."
Yamazaki N.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 433-675, VARIANTS LEU-489 AND VAL-604.
Tissue: Tongue.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB199796 mRNA. Translation: BAF43710.1.
AK123597 mRNA. Translation: BAC85655.1. Different initiation.
RefSeqNP_001001669.2. NM_001001669.2.
XP_005268504.1. XM_005268447.2.
UniGeneHs.256206.

3D structure databases

ProteinModelPortalA1IGU5.
SMRA1IGU5. Positions 24-212, 504-663.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA1IGU5.

Proteomic databases

PaxDbA1IGU5.
PRIDEA1IGU5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333677; ENSP00000328083; ENSG00000183111.
GeneID389337.
KEGGhsa:389337.
UCSCuc003lra.1. human.

Organism-specific databases

CTD389337.
GeneCardsGC05P148961.
HGNCHGNC:34430. ARHGEF37.
HPAHPA043885.
neXtProtNX_A1IGU5.
PharmGKBPA165660135.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG325944.
HOGENOMHOG000155522.
HOVERGENHBG103401.
InParanoidA1IGU5.
OMAVYKVYCA.
OrthoDBEOG7M3J14.
PhylomeDBA1IGU5.
TreeFamTF330015.

Gene expression databases

ArrayExpressA1IGU5.
BgeeA1IGU5.
GenevestigatorA1IGU5.

Family and domain databases

Gene3D1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF03114. BAR. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTSM00325. RhoGEF. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEPS51021. BAR. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi389337.
NextBio102796.
PROA1IGU5.

Entry information

Entry nameARH37_HUMAN
AccessionPrimary (citable) accession number: A1IGU5
Secondary accession number(s): Q6ZW51
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 16, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM