A1IGU5 (ARH37_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho guanine nucleotide exchange factor 37

Gene names

Name:

ARHGEF37

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	675 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a guanine nucleotide exchange factor (GEF) By similarity.
Sequence similarities	Contains 1 BAR domain. Contains 1 DH (DBL-homology) domain. Contains 2 SH3 domains.
Sequence caution	The sequence BAC85655.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat SH3 domain
Molecular function	Guanine-nucleotide releasing factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 675	675	Rho guanine nucleotide exchange factor 37		PRO_0000337050
Regions
	Domain	30 – 213	184	DH
	Domain	254 – 455	202	BAR
	Domain	506 – 569	64	SH3 1
	Domain	602 – 665	64	SH3 2
Natural variations
	Natural variant	421	1	M → L. Corresponds to variant rs4629585 [ dbSNP | Ensembl ].		VAR_043579
	Natural variant	489	1	P → L. Ref.2 Corresponds to variant rs9324624 [ dbSNP | Ensembl ].		VAR_043580
	Natural variant	518	1	S → R. Corresponds to variant rs7732714 [ dbSNP | Ensembl ].		VAR_043581
	Natural variant	586	1	P → T. Corresponds to variant rs3733662 [ dbSNP | Ensembl ].		VAR_043582
	Natural variant	604	1	M → V. Ref.2 Corresponds to variant rs1135093 [ dbSNP | Ensembl ].		VAR_043583

Sequences

	Sequence		Length	Mass (Da)
	A1IGU5 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: 90EC3F5B7BFA7178	FASTA	675	76,278
	10 20 30 40 50 60 MAKHGADEPS SRSGSPDREG RASEDRSLLH QRLAVRELID TEVSYLHMLQ LCASDIRSRL 70 80 90 100 110 120 QQLPQGDLDV LFSNIDDIIK VNSRFLHDLQ ETASKEEEQV QLVGNIFLEF QEELEQVYKV 130 140 150 160 170 180 YCASYDQALL LVDTYRKEPE LQRHIQGIVE AVVPQAGSSG LSFLLVIPLQ RITRYPLLLQ 190 200 210 220 230 240 KILENTVPDA SAYPVLQRAV SALQDVNTNI NEYKMRKEVA SKYTKVEQLT LRERLARINT 250 260 270 280 290 300 HTLSKKTTRL SQLLKQEAGL IPRTEDKEFD DLEERFQWVS LCVTELKNNV AAYLDNLQAF 310 320 330 340 350 360 LYFRPHEYNL DIPEGPAVQY CNLARDLHLE AFLKFKQRLE GLVWQPLCSL AKALLGPQNL 370 380 390 400 410 420 IKKRLDKLLD FERVEEKLLE VGSVTYQEEA ARHTYQALNS LLVAELPQFN QLVMQWLGQI 430 440 450 460 470 480 MCTFVTLQRD LAKQVLQRAE GSMAQLPHHH VPEPAFRKLV EDALGRTSNQ LRSFQETFEK 490 500 510 520 530 540 VQPPPTTQPL LPGSERQVQA LLSRYGPGKL YQVTSNISGT GTLDLTLPRG QIVAILQNKD 550 560 570 580 590 600 TKGNSGRWLV DTGGHRGYVP AGKLQLYHVV PSAEELRRQA GLNKDPRCLT PEPSPALVPS 610 620 630 640 650 660 IPTMNQVIAA YPFVARSSHE VSLQAGQPVT ILEAQDKKGN PEWSLVEVNG QRGYVPSGFL 670 ARARSPVLWG WSLPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Hypothetical proteins, rat 2-88 (Tuba 3) and its homologs of mouse and human." Yamazaki N. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 433-675, VARIANTS LEU-489 AND VAL-604. Tissue: Tongue.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB199796 mRNA. Translation: BAF43710.1. AK123597 mRNA. Translation: BAC85655.1. Different initiation.
IPI	IPI00374285.
RefSeq	NP_001001669.2. NM_001001669.2.
UniGene	Hs.256206.
3D structure databases
ProteinModelPortal	A1IGU5.
ModBase	Search...
PTM databases
PhosphoSite	A1IGU5.
Proteomic databases
PaxDb	A1IGU5.
PRIDE	A1IGU5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000333677; ENSP00000328083; ENSG00000183111.
GeneID	389337.
KEGG	hsa:389337.
UCSC	uc003lra.1. human.
Organism-specific databases
CTD	389337.
GeneCards	GC05P148961.
HGNC	HGNC:34430. ARHGEF37.
neXtProt	NX_A1IGU5.
PharmGKB	PA165660135.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG325944.
HOGENOM	HOG000155522.
HOVERGEN	HBG103401.
InParanoid	A1IGU5.
OMA	VYKVYCA.
OrthoDB	EOG4CZBFD.
Gene expression databases
ArrayExpress	A1IGU5.
Bgee	A1IGU5.
Genevestigator	A1IGU5.
Family and domain databases
Gene3D	1.20.1270.60. 1 hit. 1.20.900.10. 1 hit.
InterPro	IPR027267. AH/BAR-dom. IPR004148. BAR_dom. IPR000219. DH-domain. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF03114. BAR. 1 hit. PF00621. RhoGEF. 1 hit. PF00018. SH3_1. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
SMART	SM00325. RhoGEF. 1 hit. SM00326. SH3. 2 hits. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit. SSF50044. SH3. 2 hits.
PROSITE	PS51021. BAR. 1 hit. PS00741. DH_1. False negative. PS50010. DH_2. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	389337.
NextBio	102796.

Entry information

Entry name

ARH37_HUMAN

Accession

Primary (citable) accession number: A1IGU5
Secondary accession number(s): Q6ZW51

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	May 1, 2013
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.