Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho guanine nucleotide exchange factor 37

Gene

ARHGEF37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a guanine nucleotide exchange factor (GEF).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-416482. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 37
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:34430. ARHGEF37.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183111.
PharmGKBiPA165660135.

Polymorphism and mutation databases

BioMutaiARHGEF37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003370501 – 675Rho guanine nucleotide exchange factor 37Add BLAST675

Proteomic databases

MaxQBiA1IGU5.
PaxDbiA1IGU5.
PRIDEiA1IGU5.

PTM databases

iPTMnetiA1IGU5.
PhosphoSitePlusiA1IGU5.

Expressioni

Gene expression databases

BgeeiENSG00000183111.
ExpressionAtlasiA1IGU5. baseline and differential.
GenevisibleiA1IGU5. HS.

Organism-specific databases

HPAiHPA043885.

Interactioni

Protein-protein interaction databases

BioGridi133100. 1 interactor.
STRINGi9606.ENSP00000328083.

Structurei

3D structure databases

ProteinModelPortaliA1IGU5.
SMRiA1IGU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 213DHPROSITE-ProRule annotationAdd BLAST184
Domaini254 – 455BARPROSITE-ProRule annotationAdd BLAST202
Domaini506 – 569SH3 1PROSITE-ProRule annotationAdd BLAST64
Domaini602 – 665SH3 2PROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Contains 1 BAR domain.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG3519. Eukaryota.
ENOG410YAZC. LUCA.
GeneTreeiENSGT00530000063159.
HOGENOMiHOG000155522.
HOVERGENiHBG103401.
InParanoidiA1IGU5.
KOiK20710.
OMAiVYKVYCA.
OrthoDBiEOG091G01C4.
PhylomeDBiA1IGU5.
TreeFamiTF330015.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEiPS51021. BAR. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1IGU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKHGADEPS SRSGSPDREG RASEDRSLLH QRLAVRELID TEVSYLHMLQ
60 70 80 90 100
LCASDIRSRL QQLPQGDLDV LFSNIDDIIK VNSRFLHDLQ ETASKEEEQV
110 120 130 140 150
QLVGNIFLEF QEELEQVYKV YCASYDQALL LVDTYRKEPE LQRHIQGIVE
160 170 180 190 200
AVVPQAGSSG LSFLLVIPLQ RITRYPLLLQ KILENTVPDA SAYPVLQRAV
210 220 230 240 250
SALQDVNTNI NEYKMRKEVA SKYTKVEQLT LRERLARINT HTLSKKTTRL
260 270 280 290 300
SQLLKQEAGL IPRTEDKEFD DLEERFQWVS LCVTELKNNV AAYLDNLQAF
310 320 330 340 350
LYFRPHEYNL DIPEGPAVQY CNLARDLHLE AFLKFKQRLE GLVWQPLCSL
360 370 380 390 400
AKALLGPQNL IKKRLDKLLD FERVEEKLLE VGSVTYQEEA ARHTYQALNS
410 420 430 440 450
LLVAELPQFN QLVMQWLGQI MCTFVTLQRD LAKQVLQRAE GSMAQLPHHH
460 470 480 490 500
VPEPAFRKLV EDALGRTSNQ LRSFQETFEK VQPPPTTQPL LPGSERQVQA
510 520 530 540 550
LLSRYGPGKL YQVTSNISGT GTLDLTLPRG QIVAILQNKD TKGNSGRWLV
560 570 580 590 600
DTGGHRGYVP AGKLQLYHVV PSAEELRRQA GLNKDPRCLT PEPSPALVPS
610 620 630 640 650
IPTMNQVIAA YPFVARSSHE VSLQAGQPVT ILEAQDKKGN PEWSLVEVNG
660 670
QRGYVPSGFL ARARSPVLWG WSLPS
Length:675
Mass (Da):76,278
Last modified:May 20, 2008 - v2
Checksum:i90EC3F5B7BFA7178
GO

Sequence cautioni

The sequence BAC85655 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043579421M → L.Corresponds to variant rs4629585dbSNPEnsembl.1
Natural variantiVAR_043580489P → L.1 PublicationCorresponds to variant rs9324624dbSNPEnsembl.1
Natural variantiVAR_043581518S → R.Corresponds to variant rs7732714dbSNPEnsembl.1
Natural variantiVAR_043582586P → T.Corresponds to variant rs3733662dbSNPEnsembl.1
Natural variantiVAR_043583604M → V.1 PublicationCorresponds to variant rs1135093dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB199796 mRNA. Translation: BAF43710.1.
AK123597 mRNA. Translation: BAC85655.1. Different initiation.
CCDSiCCDS43385.1.
RefSeqiNP_001001669.2. NM_001001669.2.
XP_005268504.1. XM_005268447.4.
XP_006714847.1. XM_006714784.3.
UniGeneiHs.256206.

Genome annotation databases

EnsembliENST00000333677; ENSP00000328083; ENSG00000183111.
GeneIDi389337.
KEGGihsa:389337.
UCSCiuc003lra.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB199796 mRNA. Translation: BAF43710.1.
AK123597 mRNA. Translation: BAC85655.1. Different initiation.
CCDSiCCDS43385.1.
RefSeqiNP_001001669.2. NM_001001669.2.
XP_005268504.1. XM_005268447.4.
XP_006714847.1. XM_006714784.3.
UniGeneiHs.256206.

3D structure databases

ProteinModelPortaliA1IGU5.
SMRiA1IGU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133100. 1 interactor.
STRINGi9606.ENSP00000328083.

PTM databases

iPTMnetiA1IGU5.
PhosphoSitePlusiA1IGU5.

Polymorphism and mutation databases

BioMutaiARHGEF37.

Proteomic databases

MaxQBiA1IGU5.
PaxDbiA1IGU5.
PRIDEiA1IGU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333677; ENSP00000328083; ENSG00000183111.
GeneIDi389337.
KEGGihsa:389337.
UCSCiuc003lra.2. human.

Organism-specific databases

CTDi389337.
GeneCardsiARHGEF37.
HGNCiHGNC:34430. ARHGEF37.
HPAiHPA043885.
neXtProtiNX_A1IGU5.
OpenTargetsiENSG00000183111.
PharmGKBiPA165660135.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3519. Eukaryota.
ENOG410YAZC. LUCA.
GeneTreeiENSGT00530000063159.
HOGENOMiHOG000155522.
HOVERGENiHBG103401.
InParanoidiA1IGU5.
KOiK20710.
OMAiVYKVYCA.
OrthoDBiEOG091G01C4.
PhylomeDBiA1IGU5.
TreeFamiTF330015.

Enzyme and pathway databases

ReactomeiR-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-416482. G alpha (12/13) signalling events.

Miscellaneous databases

ChiTaRSiARHGEF37. human.
GenomeRNAii389337.
PROiA1IGU5.

Gene expression databases

BgeeiENSG00000183111.
ExpressionAtlasiA1IGU5. baseline and differential.
GenevisibleiA1IGU5. HS.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00721. BAR. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEiPS51021. BAR. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARH37_HUMAN
AccessioniPrimary (citable) accession number: A1IGU5
Secondary accession number(s): Q6ZW51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 30, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.