ID   ARH37_MOUSE             Reviewed;         676 AA.
AC   A1IGU4; Q8C0M3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   24-JAN-2024, entry version 104.
DE   RecName: Full=Rho guanine nucleotide exchange factor 37;
GN   Name=Arhgef37;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   STRAIN=ddY;
RA   Yamazaki N.;
RT   "Hypothetical proteins, rat 2-88 (Tuba 3) and its homologs of mouse and
RT   human.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- FUNCTION: May act as a guanine nucleotide exchange factor (GEF).
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A1IGU4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A1IGU4-2; Sequence=VSP_033856;
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DR   EMBL; AB199795; BAF43709.1; -; mRNA.
DR   EMBL; AK030242; BAC26861.1; -; mRNA.
DR   CCDS; CCDS50302.1; -. [A1IGU4-1]
DR   RefSeq; NP_808496.2; NM_177828.4.
DR   AlphaFoldDB; A1IGU4; -.
DR   SMR; A1IGU4; -.
DR   STRING; 10090.ENSMUSP00000130560; -.
DR   iPTMnet; A1IGU4; -.
DR   PhosphoSitePlus; A1IGU4; -.
DR   MaxQB; A1IGU4; -.
DR   PaxDb; 10090-ENSMUSP00000130560; -.
DR   PeptideAtlas; A1IGU4; -.
DR   ProteomicsDB; 283200; -. [A1IGU4-1]
DR   ProteomicsDB; 283201; -. [A1IGU4-2]
DR   Antibodypedia; 71502; 21 antibodies from 10 providers.
DR   DNASU; 328967; -.
DR   Ensembl; ENSMUST00000236608.2; ENSMUSP00000157463.2; ENSMUSG00000045094.9. [A1IGU4-2]
DR   GeneID; 328967; -.
DR   KEGG; mmu:328967; -.
DR   AGR; MGI:3045339; -.
DR   CTD; 389337; -.
DR   MGI; MGI:3045339; Arhgef37.
DR   VEuPathDB; HostDB:ENSMUSG00000045094; -.
DR   eggNOG; KOG3519; Eukaryota.
DR   GeneTree; ENSGT00950000183088; -.
DR   InParanoid; A1IGU4; -.
DR   OrthoDB; 25601at2759; -.
DR   PhylomeDB; A1IGU4; -.
DR   Reactome; R-MMU-193648; NRAGE signals death through JNK.
DR   Reactome; R-MMU-416482; G alpha (12/13) signalling events.
DR   BioGRID-ORCS; 328967; 5 hits in 78 CRISPR screens.
DR   ChiTaRS; Arhgef37; mouse.
DR   PRO; PR:A1IGU4; -.
DR   Proteomes; UP000000589; Chromosome 18.
DR   RNAct; A1IGU4; Protein.
DR   Bgee; ENSMUSG00000045094; Expressed in tail skin and 123 other cell types or tissues.
DR   ExpressionAtlas; A1IGU4; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   CDD; cd07589; BAR_DNMBP; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd11799; SH3_ARHGEF37_C1; 1.
DR   CDD; cd11941; SH3_ARHGEF37_C2; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 2.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR035636; ARHGEF37_SH3_2.
DR   InterPro; IPR035823; ARHGEF37_SH3_C1.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR22834; NUCLEAR FUSION PROTEIN FUS2; 1.
DR   PANTHER; PTHR22834:SF9; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 37; 1.
DR   Pfam; PF03114; BAR; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00721; BAR; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 2.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50044; SH3-domain; 2.
DR   PROSITE; PS51021; BAR; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50002; SH3; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Guanine-nucleotide releasing factor;
KW   Reference proteome; Repeat; SH3 domain.
FT   CHAIN           1..676
FT                   /note="Rho guanine nucleotide exchange factor 37"
FT                   /id="PRO_0000337051"
FT   DOMAIN          30..213
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   DOMAIN          254..455
FT                   /note="BAR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00361"
FT   DOMAIN          506..569
FT                   /note="SH3 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DOMAIN          603..666
FT                   /note="SH3 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..153
FT                   /note="MADFGADEASSKSESPEQEDQGSEDRSLLHQRLAIRELIDTEVSYLHTLRLC
FT                   ASDIRSHLQQLPPGDLDILFSNIDDIIQVSSRFLRGLQETACREEEQAHLIGNLFLEFQ
FT                   EEFEQVYKVYCANYDQALLLVKAYQKEPELQKEIQGIIEAAM -> MVSTCLTATFSLR
FT                   (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_033856"
SQ   SEQUENCE   676 AA;  76524 MW;  6D9BD8BE17F4912D CRC64;
     MADFGADEAS SKSESPEQED QGSEDRSLLH QRLAIRELID TEVSYLHTLR LCASDIRSHL
     QQLPPGDLDI LFSNIDDIIQ VSSRFLRGLQ ETACREEEQA HLIGNLFLEF QEEFEQVYKV
     YCANYDQALL LVKAYQKEPE LQKEIQGIIE AAMPQAGPSG LSFFLVIPLQ RITKYPLLLQ
     KILENTPADA SAHPALQRAT SALQDVNGNI NEYKMRKEVA LKYTKVEQLS LRERLARINT
     HTLSKKTTRL SQMLKQEAGL VSRTEDKEFD DLEERFQWVS LCVKELRNNV VDFMGNLEVF
     LSFRPHERSL DIPGGPAEQY CSLARDLQLH AFLQFKQRLR SLVWQPLCSL ARALAGPQNL
     IKKRLDKLLD FDRVEEKLLD VGSVTWEEEA ARHEYQALNS LLVAELPQFN QLVMQWLGQI
     LCTFVVLQRD LADQVLRRAE STMALLPHHH VSEPDFQKLL EHTLGQSSSQ LRLFQESFEK
     VLPPSTTQPL LPGSEHQMQA LLTRYGPEKL YQVSSNINGT GTLDLTLLRG QIVALLQNKD
     TKGNNSRWLV DTGGHRGYVP AGKLQLYHPI IPSEKELRGQ TGTHEDSWLP APEPTQLSVP
     TVPTMSQVVA VYPFVARSTH ELSLQAGQPV TILEAQDKKG NPEWSLVEAN GQRGYVPSNF
     LARTPSPTPW GWNLPS
//