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Protein

Rho guanine nucleotide exchange factor 37

Gene

Arhgef37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a guanine nucleotide exchange factor (GEF).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 37
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3045339. Arhgef37.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003370511 – 676Rho guanine nucleotide exchange factor 37Add BLAST676

Proteomic databases

MaxQBiA1IGU4.
PaxDbiA1IGU4.
PeptideAtlasiA1IGU4.
PRIDEiA1IGU4.

PTM databases

iPTMnetiA1IGU4.
PhosphoSitePlusiA1IGU4.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130560.

Structurei

3D structure databases

ProteinModelPortaliA1IGU4.
SMRiA1IGU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 213DHPROSITE-ProRule annotationAdd BLAST184
Domaini254 – 455BARPROSITE-ProRule annotationAdd BLAST202
Domaini506 – 569SH3 1PROSITE-ProRule annotationAdd BLAST64
Domaini603 – 666SH3 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG3519. Eukaryota.
ENOG410YAZC. LUCA.
HOGENOMiHOG000155522.
HOVERGENiHBG103401.
InParanoidiA1IGU4.
KOiK20710.
PhylomeDBiA1IGU4.

Family and domain databases

CDDicd00160. RhoGEF. 1 hit.
cd11799. SH3_ARHGEF37_C1. 1 hit.
cd11941. SH3_ARHGEF37_C2. 1 hit.
Gene3Di1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProiView protein in InterPro
IPR027267. AH/BAR_dom_sf.
IPR035636. ARHGEF37_SH3_2.
IPR035823. ARHGEF37_SH3_C1.
IPR004148. BAR_dom.
IPR035899. DBL_dom_sf.
IPR000219. DH-domain.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF03114. BAR. 1 hit.
PF00621. RhoGEF. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
SMARTiView protein in SMART
SM00721. BAR. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 2 hits.
SUPFAMiSSF103657. SSF103657. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEiView protein in PROSITE
PS51021. BAR. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A1IGU4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADFGADEAS SKSESPEQED QGSEDRSLLH QRLAIRELID TEVSYLHTLR
60 70 80 90 100
LCASDIRSHL QQLPPGDLDI LFSNIDDIIQ VSSRFLRGLQ ETACREEEQA
110 120 130 140 150
HLIGNLFLEF QEEFEQVYKV YCANYDQALL LVKAYQKEPE LQKEIQGIIE
160 170 180 190 200
AAMPQAGPSG LSFFLVIPLQ RITKYPLLLQ KILENTPADA SAHPALQRAT
210 220 230 240 250
SALQDVNGNI NEYKMRKEVA LKYTKVEQLS LRERLARINT HTLSKKTTRL
260 270 280 290 300
SQMLKQEAGL VSRTEDKEFD DLEERFQWVS LCVKELRNNV VDFMGNLEVF
310 320 330 340 350
LSFRPHERSL DIPGGPAEQY CSLARDLQLH AFLQFKQRLR SLVWQPLCSL
360 370 380 390 400
ARALAGPQNL IKKRLDKLLD FDRVEEKLLD VGSVTWEEEA ARHEYQALNS
410 420 430 440 450
LLVAELPQFN QLVMQWLGQI LCTFVVLQRD LADQVLRRAE STMALLPHHH
460 470 480 490 500
VSEPDFQKLL EHTLGQSSSQ LRLFQESFEK VLPPSTTQPL LPGSEHQMQA
510 520 530 540 550
LLTRYGPEKL YQVSSNINGT GTLDLTLLRG QIVALLQNKD TKGNNSRWLV
560 570 580 590 600
DTGGHRGYVP AGKLQLYHPI IPSEKELRGQ TGTHEDSWLP APEPTQLSVP
610 620 630 640 650
TVPTMSQVVA VYPFVARSTH ELSLQAGQPV TILEAQDKKG NPEWSLVEAN
660 670
GQRGYVPSNF LARTPSPTPW GWNLPS
Length:676
Mass (Da):76,524
Last modified:February 6, 2007 - v1
Checksum:i6D9BD8BE17F4912D
GO
Isoform 2 (identifier: A1IGU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: MADFGADEAS...EIQGIIEAAM → MVSTCLTATFSLR

Note: No experimental confirmation available.
Show »
Length:536
Mass (Da):60,435
Checksum:i77BDC02D960CEF78
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0338561 – 153MADFG…IEAAM → MVSTCLTATFSLR in isoform 2. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB199795 mRNA. Translation: BAF43709.1.
AK030242 mRNA. Translation: BAC26861.1.
CCDSiCCDS50302.1. [A1IGU4-1]
RefSeqiNP_808496.2. NM_177828.4.
UniGeneiMm.488098.

Genome annotation databases

GeneIDi328967.
KEGGimmu:328967.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARH37_MOUSE
AccessioniPrimary (citable) accession number: A1IGU4
Secondary accession number(s): Q8C0M3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: November 22, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot