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A1IGU4

- ARH37_MOUSE

UniProt

A1IGU4 - ARH37_MOUSE

Protein

Rho guanine nucleotide exchange factor 37

Gene

Arhgef37

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    May act as a guanine nucleotide exchange factor (GEF).By similarity

    GO - Molecular functioni

    1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho guanine nucleotide exchange factor 37
    Gene namesi
    Name:Arhgef37
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:3045339. Arhgef37.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 676676Rho guanine nucleotide exchange factor 37PRO_0000337051Add
    BLAST

    Proteomic databases

    PaxDbiA1IGU4.
    PRIDEiA1IGU4.

    PTM databases

    PhosphoSiteiA1IGU4.

    Expressioni

    Gene expression databases

    GenevestigatoriA1IGU4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000053241.

    Structurei

    3D structure databases

    ProteinModelPortaliA1IGU4.
    SMRiA1IGU4. Positions 24-252, 504-569, 610-664.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 213184DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini254 – 455202BARPROSITE-ProRule annotationAdd
    BLAST
    Domaini502 – 56968SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini603 – 66664SH3 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BAR domain.PROSITE-ProRule annotation
    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 2 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG325944.
    HOGENOMiHOG000155522.
    HOVERGENiHBG103401.
    InParanoidiA1IGU4.
    PhylomeDBiA1IGU4.

    Family and domain databases

    Gene3Di1.20.1270.60. 1 hit.
    1.20.900.10. 1 hit.
    InterProiIPR027267. AH/BAR-dom.
    IPR004148. BAR_dom.
    IPR000219. DH-domain.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF03114. BAR. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF07653. SH3_2. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00325. RhoGEF. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 2 hits.
    PROSITEiPS51021. BAR. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A1IGU4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADFGADEAS SKSESPEQED QGSEDRSLLH QRLAIRELID TEVSYLHTLR    50
    LCASDIRSHL QQLPPGDLDI LFSNIDDIIQ VSSRFLRGLQ ETACREEEQA 100
    HLIGNLFLEF QEEFEQVYKV YCANYDQALL LVKAYQKEPE LQKEIQGIIE 150
    AAMPQAGPSG LSFFLVIPLQ RITKYPLLLQ KILENTPADA SAHPALQRAT 200
    SALQDVNGNI NEYKMRKEVA LKYTKVEQLS LRERLARINT HTLSKKTTRL 250
    SQMLKQEAGL VSRTEDKEFD DLEERFQWVS LCVKELRNNV VDFMGNLEVF 300
    LSFRPHERSL DIPGGPAEQY CSLARDLQLH AFLQFKQRLR SLVWQPLCSL 350
    ARALAGPQNL IKKRLDKLLD FDRVEEKLLD VGSVTWEEEA ARHEYQALNS 400
    LLVAELPQFN QLVMQWLGQI LCTFVVLQRD LADQVLRRAE STMALLPHHH 450
    VSEPDFQKLL EHTLGQSSSQ LRLFQESFEK VLPPSTTQPL LPGSEHQMQA 500
    LLTRYGPEKL YQVSSNINGT GTLDLTLLRG QIVALLQNKD TKGNNSRWLV 550
    DTGGHRGYVP AGKLQLYHPI IPSEKELRGQ TGTHEDSWLP APEPTQLSVP 600
    TVPTMSQVVA VYPFVARSTH ELSLQAGQPV TILEAQDKKG NPEWSLVEAN 650
    GQRGYVPSNF LARTPSPTPW GWNLPS 676
    Length:676
    Mass (Da):76,524
    Last modified:February 6, 2007 - v1
    Checksum:i6D9BD8BE17F4912D
    GO
    Isoform 2 (identifier: A1IGU4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-153: MADFGADEAS...EIQGIIEAAM → MVSTCLTATFSLR

    Note: No experimental confirmation available.

    Show »
    Length:536
    Mass (Da):60,435
    Checksum:i77BDC02D960CEF78
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 153153MADFG…IEAAM → MVSTCLTATFSLR in isoform 2. 1 PublicationVSP_033856Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB199795 mRNA. Translation: BAF43709.1.
    AK030242 mRNA. Translation: BAC26861.1.
    CCDSiCCDS50302.1. [A1IGU4-1]
    RefSeqiNP_808496.2. NM_177828.4.
    UniGeneiMm.488098.

    Genome annotation databases

    GeneIDi328967.
    KEGGimmu:328967.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB199795 mRNA. Translation: BAF43709.1 .
    AK030242 mRNA. Translation: BAC26861.1 .
    CCDSi CCDS50302.1. [A1IGU4-1 ]
    RefSeqi NP_808496.2. NM_177828.4.
    UniGenei Mm.488098.

    3D structure databases

    ProteinModelPortali A1IGU4.
    SMRi A1IGU4. Positions 24-252, 504-569, 610-664.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000053241.

    PTM databases

    PhosphoSitei A1IGU4.

    Proteomic databases

    PaxDbi A1IGU4.
    PRIDEi A1IGU4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 328967.
    KEGGi mmu:328967.

    Organism-specific databases

    CTDi 389337.
    MGIi MGI:3045339. Arhgef37.

    Phylogenomic databases

    eggNOGi NOG325944.
    HOGENOMi HOG000155522.
    HOVERGENi HBG103401.
    InParanoidi A1IGU4.
    PhylomeDBi A1IGU4.

    Miscellaneous databases

    NextBioi 398515.
    PROi A1IGU4.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori A1IGU4.

    Family and domain databases

    Gene3Di 1.20.1270.60. 1 hit.
    1.20.900.10. 1 hit.
    InterProi IPR027267. AH/BAR-dom.
    IPR004148. BAR_dom.
    IPR000219. DH-domain.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF03114. BAR. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF07653. SH3_2. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 2 hits.
    PROSITEi PS51021. BAR. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hypothetical proteins, rat 2-88 (Tuba 3) and its homologs of mouse and human."
      Yamazaki N.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: ddY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Testis.

    Entry informationi

    Entry nameiARH37_MOUSE
    AccessioniPrimary (citable) accession number: A1IGU4
    Secondary accession number(s): Q8C0M3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3