A1IGU4 (ARH37_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho guanine nucleotide exchange factor 37

Gene names

Name:

Arhgef37

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	676 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as a guanine nucleotide exchange factor (GEF) By similarity.
Sequence similarities	Contains 1 BAR domain. Contains 1 DH (DBL-homology) domain. Contains 2 SH3 domains.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat SH3 domain
Molecular function	Guanine-nucleotide releasing factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A1IGU4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A1IGU4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: MADFGADEAS...EIQGIIEAAM → MVSTCLTATFSLR

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 676	676	Rho guanine nucleotide exchange factor 37		PRO_0000337051
Regions
	Domain	30 – 213	184	DH
	Domain	254 – 455	202	BAR
	Domain	502 – 569	68	SH3 1
	Domain	603 – 666	64	SH3 2
Natural variations
	Alternative sequence	1 – 153	153	MADFG…IEAAM → MVSTCLTATFSLR in isoform 2.		VSP_033856

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 6D9BD8BE17F4912D	FASTA	676	76,524
	10 20 30 40 50 60 MADFGADEAS SKSESPEQED QGSEDRSLLH QRLAIRELID TEVSYLHTLR LCASDIRSHL 70 80 90 100 110 120 QQLPPGDLDI LFSNIDDIIQ VSSRFLRGLQ ETACREEEQA HLIGNLFLEF QEEFEQVYKV 130 140 150 160 170 180 YCANYDQALL LVKAYQKEPE LQKEIQGIIE AAMPQAGPSG LSFFLVIPLQ RITKYPLLLQ 190 200 210 220 230 240 KILENTPADA SAHPALQRAT SALQDVNGNI NEYKMRKEVA LKYTKVEQLS LRERLARINT 250 260 270 280 290 300 HTLSKKTTRL SQMLKQEAGL VSRTEDKEFD DLEERFQWVS LCVKELRNNV VDFMGNLEVF 310 320 330 340 350 360 LSFRPHERSL DIPGGPAEQY CSLARDLQLH AFLQFKQRLR SLVWQPLCSL ARALAGPQNL 370 380 390 400 410 420 IKKRLDKLLD FDRVEEKLLD VGSVTWEEEA ARHEYQALNS LLVAELPQFN QLVMQWLGQI 430 440 450 460 470 480 LCTFVVLQRD LADQVLRRAE STMALLPHHH VSEPDFQKLL EHTLGQSSSQ LRLFQESFEK 490 500 510 520 530 540 VLPPSTTQPL LPGSEHQMQA LLTRYGPEKL YQVSSNINGT GTLDLTLLRG QIVALLQNKD 550 560 570 580 590 600 TKGNNSRWLV DTGGHRGYVP AGKLQLYHPI IPSEKELRGQ TGTHEDSWLP APEPTQLSVP 610 620 630 640 650 660 TVPTMSQVVA VYPFVARSTH ELSLQAGQPV TILEAQDKKG NPEWSLVEAN GQRGYVPSNF 670 LARTPSPTPW GWNLPS
	Isoform 2 [UniParc]. Checksum: 77BDC02D960CEF78	FASTA	536	60,435
	10 20 30 40 50 60 MVSTCLTATF SLRPQAGPSG LSFFLVIPLQ RITKYPLLLQ KILENTPADA SAHPALQRAT 70 80 90 100 110 120 SALQDVNGNI NEYKMRKEVA LKYTKVEQLS LRERLARINT HTLSKKTTRL SQMLKQEAGL 130 140 150 160 170 180 VSRTEDKEFD DLEERFQWVS LCVKELRNNV VDFMGNLEVF LSFRPHERSL DIPGGPAEQY 190 200 210 220 230 240 CSLARDLQLH AFLQFKQRLR SLVWQPLCSL ARALAGPQNL IKKRLDKLLD FDRVEEKLLD 250 260 270 280 290 300 VGSVTWEEEA ARHEYQALNS LLVAELPQFN QLVMQWLGQI LCTFVVLQRD LADQVLRRAE 310 320 330 340 350 360 STMALLPHHH VSEPDFQKLL EHTLGQSSSQ LRLFQESFEK VLPPSTTQPL LPGSEHQMQA 370 380 390 400 410 420 LLTRYGPEKL YQVSSNINGT GTLDLTLLRG QIVALLQNKD TKGNNSRWLV DTGGHRGYVP 430 440 450 460 470 480 AGKLQLYHPI IPSEKELRGQ TGTHEDSWLP APEPTQLSVP TVPTMSQVVA VYPFVARSTH 490 500 510 520 530 ELSLQAGQPV TILEAQDKKG NPEWSLVEAN GQRGYVPSNF LARTPSPTPW GWNLPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Hypothetical proteins, rat 2-88 (Tuba 3) and its homologs of mouse and human." Yamazaki N. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: ddY.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB199795 mRNA. Translation: BAF43709.1. AK030242 mRNA. Translation: BAC26861.1.
IPI	IPI00223868. IPI00894812.
RefSeq	NP_808496.2. NM_177828.4.
UniGene	Mm.488098.
3D structure databases
ProteinModelPortal	A1IGU4.
SMR	A1IGU4. Positions 24-252, 504-569, 610-666.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000053241.
PTM databases
PhosphoSite	A1IGU4.
Proteomic databases
PaxDb	A1IGU4.
PRIDE	A1IGU4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	328967.
KEGG	mmu:328967.
UCSC	uc008fca.2. mouse.
Organism-specific databases
CTD	389337.
MGI	MGI:3045339. Arhgef37.
Phylogenomic databases
eggNOG	NOG325944.
HOGENOM	HOG000155522.
HOVERGEN	HBG103401.
InParanoid	A1IGU4.
OrthoDB	EOG4CZBFD.
Gene expression databases
Genevestigator	A1IGU4.
Family and domain databases
Gene3D	1.20.1270.60. 1 hit. 1.20.900.10. 1 hit.
InterPro	IPR027267. AH/BAR-dom. IPR004148. BAR_dom. IPR000219. DH-domain. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF03114. BAR. 1 hit. PF00621. RhoGEF. 1 hit. PF00018. SH3_1. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
SMART	SM00325. RhoGEF. 1 hit. SM00326. SH3. 2 hits. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit. SSF50044. SH3. 2 hits.
PROSITE	PS51021. BAR. 1 hit. PS00741. DH_1. False negative. PS50010. DH_2. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	398515.
SOURCE	Search...

Entry information

Entry name

ARH37_MOUSE

Accession

Primary (citable) accession number: A1IGU4
Secondary accession number(s): Q8C0M3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program