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A1IGU4 (ARH37_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho guanine nucleotide exchange factor 37
Gene names
Name:Arhgef37
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length676 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a guanine nucleotide exchange factor (GEF) By similarity.

Sequence similarities

Contains 1 BAR domain.

Contains 1 DH (DBL-homology) domain.

Contains 2 SH3 domains.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainRepeat
SH3 domain
   Molecular functionGuanine-nucleotide releasing factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRho guanyl-nucleotide exchange factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A1IGU4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A1IGU4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: MADFGADEAS...EIQGIIEAAM → MVSTCLTATFSLR
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 676676Rho guanine nucleotide exchange factor 37
PRO_0000337051

Regions

Domain30 – 213184DH
Domain254 – 455202BAR
Domain502 – 56968SH3 1
Domain603 – 66664SH3 2

Natural variations

Alternative sequence1 – 153153MADFG…IEAAM → MVSTCLTATFSLR in isoform 2.
VSP_033856

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 6D9BD8BE17F4912D

FASTA67676,524
        10         20         30         40         50         60 
MADFGADEAS SKSESPEQED QGSEDRSLLH QRLAIRELID TEVSYLHTLR LCASDIRSHL 

        70         80         90        100        110        120 
QQLPPGDLDI LFSNIDDIIQ VSSRFLRGLQ ETACREEEQA HLIGNLFLEF QEEFEQVYKV 

       130        140        150        160        170        180 
YCANYDQALL LVKAYQKEPE LQKEIQGIIE AAMPQAGPSG LSFFLVIPLQ RITKYPLLLQ 

       190        200        210        220        230        240 
KILENTPADA SAHPALQRAT SALQDVNGNI NEYKMRKEVA LKYTKVEQLS LRERLARINT 

       250        260        270        280        290        300 
HTLSKKTTRL SQMLKQEAGL VSRTEDKEFD DLEERFQWVS LCVKELRNNV VDFMGNLEVF 

       310        320        330        340        350        360 
LSFRPHERSL DIPGGPAEQY CSLARDLQLH AFLQFKQRLR SLVWQPLCSL ARALAGPQNL 

       370        380        390        400        410        420 
IKKRLDKLLD FDRVEEKLLD VGSVTWEEEA ARHEYQALNS LLVAELPQFN QLVMQWLGQI 

       430        440        450        460        470        480 
LCTFVVLQRD LADQVLRRAE STMALLPHHH VSEPDFQKLL EHTLGQSSSQ LRLFQESFEK 

       490        500        510        520        530        540 
VLPPSTTQPL LPGSEHQMQA LLTRYGPEKL YQVSSNINGT GTLDLTLLRG QIVALLQNKD 

       550        560        570        580        590        600 
TKGNNSRWLV DTGGHRGYVP AGKLQLYHPI IPSEKELRGQ TGTHEDSWLP APEPTQLSVP 

       610        620        630        640        650        660 
TVPTMSQVVA VYPFVARSTH ELSLQAGQPV TILEAQDKKG NPEWSLVEAN GQRGYVPSNF 

       670 
LARTPSPTPW GWNLPS 

« Hide

Isoform 2 [UniParc].

Checksum: 77BDC02D960CEF78
Show »

FASTA53660,435

References

« Hide 'large scale' references
[1]"Hypothetical proteins, rat 2-88 (Tuba 3) and its homologs of mouse and human."
Yamazaki N.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: ddY.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB199795 mRNA. Translation: BAF43709.1.
AK030242 mRNA. Translation: BAC26861.1.
RefSeqNP_808496.2. NM_177828.4.
UniGeneMm.488098.

3D structure databases

ProteinModelPortalA1IGU4.
SMRA1IGU4. Positions 24-252, 504-665.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000053241.

PTM databases

PhosphoSiteA1IGU4.

Proteomic databases

PaxDbA1IGU4.
PRIDEA1IGU4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID328967.
KEGGmmu:328967.

Organism-specific databases

CTD389337.
MGIMGI:3045339. Arhgef37.

Phylogenomic databases

eggNOGNOG325944.
HOGENOMHOG000155522.
HOVERGENHBG103401.
InParanoidA1IGU4.
PhylomeDBA1IGU4.

Gene expression databases

GenevestigatorA1IGU4.

Family and domain databases

Gene3D1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF03114. BAR. 1 hit.
PF00621. RhoGEF. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTSM00325. RhoGEF. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEPS51021. BAR. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio398515.
PROA1IGU4.
SOURCESearch...

Entry information

Entry nameARH37_MOUSE
AccessionPrimary (citable) accession number: A1IGU4
Secondary accession number(s): Q8C0M3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot