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A1IGU4

- ARH37_MOUSE

UniProt

A1IGU4 - ARH37_MOUSE

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Protein

Rho guanine nucleotide exchange factor 37

Gene

Arhgef37

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

May act as a guanine nucleotide exchange factor (GEF).By similarity

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 37
Gene namesi
Name:Arhgef37
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:3045339. Arhgef37.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 676676Rho guanine nucleotide exchange factor 37PRO_0000337051Add
BLAST

Proteomic databases

PaxDbiA1IGU4.
PRIDEiA1IGU4.

PTM databases

PhosphoSiteiA1IGU4.

Expressioni

Gene expression databases

GenevestigatoriA1IGU4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053241.

Structurei

3D structure databases

ProteinModelPortaliA1IGU4.
SMRiA1IGU4. Positions 24-252, 504-569, 610-664.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 213184DHPROSITE-ProRule annotationAdd
BLAST
Domaini254 – 455202BARPROSITE-ProRule annotationAdd
BLAST
Domaini502 – 56968SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini603 – 66664SH3 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BAR domain.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG325944.
HOGENOMiHOG000155522.
HOVERGENiHBG103401.
InParanoidiA1IGU4.
PhylomeDBiA1IGU4.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00621. RhoGEF. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEiPS51021. BAR. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A1IGU4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADFGADEAS SKSESPEQED QGSEDRSLLH QRLAIRELID TEVSYLHTLR
60 70 80 90 100
LCASDIRSHL QQLPPGDLDI LFSNIDDIIQ VSSRFLRGLQ ETACREEEQA
110 120 130 140 150
HLIGNLFLEF QEEFEQVYKV YCANYDQALL LVKAYQKEPE LQKEIQGIIE
160 170 180 190 200
AAMPQAGPSG LSFFLVIPLQ RITKYPLLLQ KILENTPADA SAHPALQRAT
210 220 230 240 250
SALQDVNGNI NEYKMRKEVA LKYTKVEQLS LRERLARINT HTLSKKTTRL
260 270 280 290 300
SQMLKQEAGL VSRTEDKEFD DLEERFQWVS LCVKELRNNV VDFMGNLEVF
310 320 330 340 350
LSFRPHERSL DIPGGPAEQY CSLARDLQLH AFLQFKQRLR SLVWQPLCSL
360 370 380 390 400
ARALAGPQNL IKKRLDKLLD FDRVEEKLLD VGSVTWEEEA ARHEYQALNS
410 420 430 440 450
LLVAELPQFN QLVMQWLGQI LCTFVVLQRD LADQVLRRAE STMALLPHHH
460 470 480 490 500
VSEPDFQKLL EHTLGQSSSQ LRLFQESFEK VLPPSTTQPL LPGSEHQMQA
510 520 530 540 550
LLTRYGPEKL YQVSSNINGT GTLDLTLLRG QIVALLQNKD TKGNNSRWLV
560 570 580 590 600
DTGGHRGYVP AGKLQLYHPI IPSEKELRGQ TGTHEDSWLP APEPTQLSVP
610 620 630 640 650
TVPTMSQVVA VYPFVARSTH ELSLQAGQPV TILEAQDKKG NPEWSLVEAN
660 670
GQRGYVPSNF LARTPSPTPW GWNLPS
Length:676
Mass (Da):76,524
Last modified:February 6, 2007 - v1
Checksum:i6D9BD8BE17F4912D
GO
Isoform 2 (identifier: A1IGU4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: MADFGADEAS...EIQGIIEAAM → MVSTCLTATFSLR

Note: No experimental confirmation available.

Show »
Length:536
Mass (Da):60,435
Checksum:i77BDC02D960CEF78
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 153153MADFG…IEAAM → MVSTCLTATFSLR in isoform 2. 1 PublicationVSP_033856Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB199795 mRNA. Translation: BAF43709.1.
AK030242 mRNA. Translation: BAC26861.1.
CCDSiCCDS50302.1. [A1IGU4-1]
RefSeqiNP_808496.2. NM_177828.4.
UniGeneiMm.488098.

Genome annotation databases

GeneIDi328967.
KEGGimmu:328967.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB199795 mRNA. Translation: BAF43709.1 .
AK030242 mRNA. Translation: BAC26861.1 .
CCDSi CCDS50302.1. [A1IGU4-1 ]
RefSeqi NP_808496.2. NM_177828.4.
UniGenei Mm.488098.

3D structure databases

ProteinModelPortali A1IGU4.
SMRi A1IGU4. Positions 24-252, 504-569, 610-664.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000053241.

PTM databases

PhosphoSitei A1IGU4.

Proteomic databases

PaxDbi A1IGU4.
PRIDEi A1IGU4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 328967.
KEGGi mmu:328967.

Organism-specific databases

CTDi 389337.
MGIi MGI:3045339. Arhgef37.

Phylogenomic databases

eggNOGi NOG325944.
HOGENOMi HOG000155522.
HOVERGENi HBG103401.
InParanoidi A1IGU4.
PhylomeDBi A1IGU4.

Miscellaneous databases

NextBioi 398515.
PROi A1IGU4.
SOURCEi Search...

Gene expression databases

Genevestigatori A1IGU4.

Family and domain databases

Gene3Di 1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProi IPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF03114. BAR. 1 hit.
PF00621. RhoGEF. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
SMARTi SM00325. RhoGEF. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEi PS51021. BAR. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Hypothetical proteins, rat 2-88 (Tuba 3) and its homologs of mouse and human."
    Yamazaki N.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: ddY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Testis.

Entry informationi

Entry nameiARH37_MOUSE
AccessioniPrimary (citable) accession number: A1IGU4
Secondary accession number(s): Q8C0M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3