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Protein

Rho guanine nucleotide exchange factor 37

Gene

Arhgef37

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a guanine nucleotide exchange factor (GEF).By similarity

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 37
Alternative name(s):
Protein 2-88
Scaffold protein tuba 3
Gene namesi
Name:Arhgef37
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1560471. Arhgef37.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 676676Rho guanine nucleotide exchange factor 37PRO_0000337052Add
BLAST

Proteomic databases

PaxDbiA1IGU3.
PRIDEiA1IGU3.

PTM databases

PhosphoSiteiA1IGU3.

Expressioni

Gene expression databases

GenevestigatoriA1IGU3.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037964.

Structurei

3D structure databases

ProteinModelPortaliA1IGU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 213184DHPROSITE-ProRule annotationAdd
BLAST
Domaini254 – 455202BARPROSITE-ProRule annotationAdd
BLAST
Domaini506 – 56964SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini603 – 66664SH3 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BAR domain.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG325944.
HOVERGENiHBG103401.
InParanoidiA1IGU3.
PhylomeDBiA1IGU3.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00621. RhoGEF. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEiPS51021. BAR. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1IGU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADFETDEAS SKSESPEQEG QGSEDKSLLH QRLAIRELID TEVSYLHTLR
60 70 80 90 100
LCTSDIRGHL QQLPPGDLDI LFSNIDDIIQ VSSRFLHGLQ ETACKEEKQA
110 120 130 140 150
HLIGNLFLEF QEELEQVYKV YCANYDQALL LVKAYQKEPE LQKEIQGIIE
160 170 180 190 200
AAVPQAGPSG LSFLLVIPLQ RITKYPLLLQ KILENTPADA SAHPVLQRAT
210 220 230 240 250
SALQDVNSNI NEYKMRKEVA LKYTKVEQLS LRERLARINT HTLSKKTTRL
260 270 280 290 300
SQLLKQEAGL VPRTEDKEFD DLEERFQWVS LCVTELKSNV AAYMDNLEAF
310 320 330 340 350
LCFRPHERNL DIPGGAAEQY CSLARDLQLQ AFLQFKQRLT GLVWQPLCSL
360 370 380 390 400
ARALVGPQNL IKKRLDKLLD FERVEEKLLD VGSVTYEEEA ARHTYQALNS
410 420 430 440 450
LIVAELPQFN HLVMQWLGQI LRTFVVLQRD LADQVLRRAE SSMALLPHRH
460 470 480 490 500
VSEPDFQKLL EDTLGQSSSQ LRHFRESFEK VLPPSTSQPL LPGSEHQMQS
510 520 530 540 550
LLTRYGPGKI YQVTSNINGT GTLDLTLPRG QIVALLQNKD TKGNNSRWLV
560 570 580 590 600
DTGGHRGYVP AGKLQLYHPI NPSEKEPRRQ TGMPEDYWLP TPEPTQPSVP
610 620 630 640 650
TVPTMSQVVA VYPFVARSTH ELSLQAGQPV TILEAQDKKG NPEWSLVEAN
660 670
GQRGYVPSNF LARTPSPTPR GWNLPS
Length:676
Mass (Da):76,407
Last modified:February 6, 2007 - v1
Checksum:i9F70CED2B387399D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB199794 mRNA. Translation: BAF43708.1.
RefSeqiNP_001094444.1. NM_001100974.1.
UniGeneiRn.211792.

Genome annotation databases

GeneIDi307398.
KEGGirno:307398.
UCSCiRGD:1560471. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB199794 mRNA. Translation: BAF43708.1.
RefSeqiNP_001094444.1. NM_001100974.1.
UniGeneiRn.211792.

3D structure databases

ProteinModelPortaliA1IGU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000037964.

PTM databases

PhosphoSiteiA1IGU3.

Proteomic databases

PaxDbiA1IGU3.
PRIDEiA1IGU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi307398.
KEGGirno:307398.
UCSCiRGD:1560471. rat.

Organism-specific databases

CTDi389337.
RGDi1560471. Arhgef37.

Phylogenomic databases

eggNOGiNOG325944.
HOVERGENiHBG103401.
InParanoidiA1IGU3.
PhylomeDBiA1IGU3.

Miscellaneous databases

NextBioi657325.

Gene expression databases

GenevestigatoriA1IGU3.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF03114. BAR. 1 hit.
PF00621. RhoGEF. 1 hit.
PF07653. SH3_2. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00325. RhoGEF. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 2 hits.
PROSITEiPS51021. BAR. 1 hit.
PS50010. DH_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Hypothetical proteins, rat 2-88 (Tuba 3) and its homologs of mouse and human."
    Yamazaki N.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.

Entry informationi

Entry nameiARH37_RAT
AccessioniPrimary (citable) accession number: A1IGU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: January 7, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.