Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1IGU3

- ARH37_RAT

UniProt

A1IGU3 - ARH37_RAT

Protein

Rho guanine nucleotide exchange factor 37

Gene

Arhgef37

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May act as a guanine nucleotide exchange factor (GEF).By similarity

    GO - Molecular functioni

    1. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho guanine nucleotide exchange factor 37
    Alternative name(s):
    Protein 2-88
    Scaffold protein tuba 3
    Gene namesi
    Name:Arhgef37
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1560471. Arhgef37.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 676676Rho guanine nucleotide exchange factor 37PRO_0000337052Add
    BLAST

    Proteomic databases

    PaxDbiA1IGU3.
    PRIDEiA1IGU3.

    PTM databases

    PhosphoSiteiA1IGU3.

    Expressioni

    Gene expression databases

    GenevestigatoriA1IGU3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000037964.

    Structurei

    3D structure databases

    ProteinModelPortaliA1IGU3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 213184DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini254 – 455202BARPROSITE-ProRule annotationAdd
    BLAST
    Domaini506 – 56964SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini603 – 66664SH3 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BAR domain.PROSITE-ProRule annotation
    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 2 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG325944.
    HOVERGENiHBG103401.
    InParanoidiA1IGU3.
    PhylomeDBiA1IGU3.

    Family and domain databases

    Gene3Di1.20.1270.60. 1 hit.
    1.20.900.10. 1 hit.
    InterProiIPR027267. AH/BAR-dom.
    IPR004148. BAR_dom.
    IPR000219. DH-domain.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF03114. BAR. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF07653. SH3_2. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00325. RhoGEF. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 2 hits.
    PROSITEiPS51021. BAR. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1IGU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADFETDEAS SKSESPEQEG QGSEDKSLLH QRLAIRELID TEVSYLHTLR    50
    LCTSDIRGHL QQLPPGDLDI LFSNIDDIIQ VSSRFLHGLQ ETACKEEKQA 100
    HLIGNLFLEF QEELEQVYKV YCANYDQALL LVKAYQKEPE LQKEIQGIIE 150
    AAVPQAGPSG LSFLLVIPLQ RITKYPLLLQ KILENTPADA SAHPVLQRAT 200
    SALQDVNSNI NEYKMRKEVA LKYTKVEQLS LRERLARINT HTLSKKTTRL 250
    SQLLKQEAGL VPRTEDKEFD DLEERFQWVS LCVTELKSNV AAYMDNLEAF 300
    LCFRPHERNL DIPGGAAEQY CSLARDLQLQ AFLQFKQRLT GLVWQPLCSL 350
    ARALVGPQNL IKKRLDKLLD FERVEEKLLD VGSVTYEEEA ARHTYQALNS 400
    LIVAELPQFN HLVMQWLGQI LRTFVVLQRD LADQVLRRAE SSMALLPHRH 450
    VSEPDFQKLL EDTLGQSSSQ LRHFRESFEK VLPPSTSQPL LPGSEHQMQS 500
    LLTRYGPGKI YQVTSNINGT GTLDLTLPRG QIVALLQNKD TKGNNSRWLV 550
    DTGGHRGYVP AGKLQLYHPI NPSEKEPRRQ TGMPEDYWLP TPEPTQPSVP 600
    TVPTMSQVVA VYPFVARSTH ELSLQAGQPV TILEAQDKKG NPEWSLVEAN 650
    GQRGYVPSNF LARTPSPTPR GWNLPS 676
    Length:676
    Mass (Da):76,407
    Last modified:February 6, 2007 - v1
    Checksum:i9F70CED2B387399D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB199794 mRNA. Translation: BAF43708.1.
    RefSeqiNP_001094444.1. NM_001100974.1.
    UniGeneiRn.211792.

    Genome annotation databases

    GeneIDi307398.
    KEGGirno:307398.
    UCSCiRGD:1560471. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB199794 mRNA. Translation: BAF43708.1 .
    RefSeqi NP_001094444.1. NM_001100974.1.
    UniGenei Rn.211792.

    3D structure databases

    ProteinModelPortali A1IGU3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000037964.

    PTM databases

    PhosphoSitei A1IGU3.

    Proteomic databases

    PaxDbi A1IGU3.
    PRIDEi A1IGU3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 307398.
    KEGGi rno:307398.
    UCSCi RGD:1560471. rat.

    Organism-specific databases

    CTDi 389337.
    RGDi 1560471. Arhgef37.

    Phylogenomic databases

    eggNOGi NOG325944.
    HOVERGENi HBG103401.
    InParanoidi A1IGU3.
    PhylomeDBi A1IGU3.

    Miscellaneous databases

    NextBioi 657325.

    Gene expression databases

    Genevestigatori A1IGU3.

    Family and domain databases

    Gene3Di 1.20.1270.60. 1 hit.
    1.20.900.10. 1 hit.
    InterProi IPR027267. AH/BAR-dom.
    IPR004148. BAR_dom.
    IPR000219. DH-domain.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF03114. BAR. 1 hit.
    PF00621. RhoGEF. 1 hit.
    PF07653. SH3_2. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00325. RhoGEF. 1 hit.
    SM00326. SH3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    SSF50044. SSF50044. 2 hits.
    PROSITEi PS51021. BAR. 1 hit.
    PS50010. DH_2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hypothetical proteins, rat 2-88 (Tuba 3) and its homologs of mouse and human."
      Yamazaki N.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.

    Entry informationi

    Entry nameiARH37_RAT
    AccessioniPrimary (citable) accession number: A1IGU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3