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A1IGU3 (ARH37_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Rho guanine nucleotide exchange factor 37
Alternative name(s):
Protein 2-88
Scaffold protein tuba 3
Gene names
Name:Arhgef37
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length676 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a guanine nucleotide exchange factor (GEF) By similarity.

Sequence similarities

Contains 1 BAR domain.

Contains 1 DH (DBL-homology) domain.

Contains 2 SH3 domains.

Ontologies

Keywords
   DomainRepeat
SH3 domain
   Molecular functionGuanine-nucleotide releasing factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of Rho protein signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRho guanyl-nucleotide exchange factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 676676Rho guanine nucleotide exchange factor 37
PRO_0000337052

Regions

Domain30 – 213184DH
Domain254 – 455202BAR
Domain506 – 56964SH3 1
Domain603 – 66664SH3 2

Sequences

Sequence LengthMass (Da)Tools
A1IGU3 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 9F70CED2B387399D

FASTA67676,407
        10         20         30         40         50         60 
MADFETDEAS SKSESPEQEG QGSEDKSLLH QRLAIRELID TEVSYLHTLR LCTSDIRGHL 

        70         80         90        100        110        120 
QQLPPGDLDI LFSNIDDIIQ VSSRFLHGLQ ETACKEEKQA HLIGNLFLEF QEELEQVYKV 

       130        140        150        160        170        180 
YCANYDQALL LVKAYQKEPE LQKEIQGIIE AAVPQAGPSG LSFLLVIPLQ RITKYPLLLQ 

       190        200        210        220        230        240 
KILENTPADA SAHPVLQRAT SALQDVNSNI NEYKMRKEVA LKYTKVEQLS LRERLARINT 

       250        260        270        280        290        300 
HTLSKKTTRL SQLLKQEAGL VPRTEDKEFD DLEERFQWVS LCVTELKSNV AAYMDNLEAF 

       310        320        330        340        350        360 
LCFRPHERNL DIPGGAAEQY CSLARDLQLQ AFLQFKQRLT GLVWQPLCSL ARALVGPQNL 

       370        380        390        400        410        420 
IKKRLDKLLD FERVEEKLLD VGSVTYEEEA ARHTYQALNS LIVAELPQFN HLVMQWLGQI 

       430        440        450        460        470        480 
LRTFVVLQRD LADQVLRRAE SSMALLPHRH VSEPDFQKLL EDTLGQSSSQ LRHFRESFEK 

       490        500        510        520        530        540 
VLPPSTSQPL LPGSEHQMQS LLTRYGPGKI YQVTSNINGT GTLDLTLPRG QIVALLQNKD 

       550        560        570        580        590        600 
TKGNNSRWLV DTGGHRGYVP AGKLQLYHPI NPSEKEPRRQ TGMPEDYWLP TPEPTQPSVP 

       610        620        630        640        650        660 
TVPTMSQVVA VYPFVARSTH ELSLQAGQPV TILEAQDKKG NPEWSLVEAN GQRGYVPSNF 

       670 
LARTPSPTPR GWNLPS

« Hide

References

[1]"Hypothetical proteins, rat 2-88 (Tuba 3) and its homologs of mouse and human."
Yamazaki N.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB199794 mRNA. Translation: BAF43708.1.
IPIIPI00367535.
RefSeqNP_001094444.1. NM_001100974.1.
UniGeneRn.211792.

3D structure databases

ProteinModelPortalA1IGU3.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000037964.

PTM databases

PhosphoSiteA1IGU3.

Proteomic databases

PaxDbA1IGU3.
PRIDEA1IGU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID307398.
KEGGrno:307398.
UCSCRGD:1560471. rat.

Organism-specific databases

CTD389337.
RGD1560471. Arhgef37.

Phylogenomic databases

eggNOGNOG325944.
HOVERGENHBG103401.
InParanoidA1IGU3.
OrthoDBEOG4CZBFD.

Gene expression databases

ArrayExpressA1IGU3.
GenevestigatorA1IGU3.

Family and domain databases

Gene3D1.20.1270.60. 1 hit.
1.20.900.10. 1 hit.
InterProIPR027267. AH/BAR-dom.
IPR004148. BAR_dom.
IPR000219. DH-domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF03114. BAR. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTSM00325. RhoGEF. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMSSF48065. DH-domain. 1 hit.
SSF50044. SH3. 2 hits.
PROSITEPS51021. BAR. 1 hit.
PS00741. DH_1. False negative.
PS50010. DH_2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio657325.

Entry information

Entry nameARH37_RAT
AccessionPrimary (citable) accession number: A1IGU3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 6, 2007
Last modified: May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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