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Protein
Submitted name:

TWiK family of potassium channels

Gene

twk-39

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotationImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-1299344 TWIK-related spinal cord K+ channel (TRESK)
R-CEL-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Submitted name:
TWiK family of potassium channelsImported
Gene namesi
Name:twk-39Imported
ORF Names:C24H11.8Imported, CELE_C24H11.8Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC24H11.8b ; CE40599 ; WBGene00006690 ; twk-39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 44HelicalSequence analysisAdd BLAST24
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei151 – 172HelicalSequence analysisAdd BLAST22
Transmembranei178 – 193HelicalSequence analysisAdd BLAST16
Transmembranei492 – 511HelicalSequence analysisAdd BLAST20
Transmembranei553 – 574HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiA1EHR5

Expressioni

Gene expression databases

BgeeiWBGene00006690
ExpressionAtlasiA1EHR5 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi6239.C24H11.8b

Structurei

3D structure databases

ProteinModelPortaliA1EHR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 175Ion_trans_2InterPro annotationAdd BLAST60
Domaini501 – 576Ion_trans_2InterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00700000104522
HOGENOMiHOG000217931
InParanoidiA1EHR5
KOiK05323
OMAiISPRTDW
OrthoDBiEOG091G03S1
PhylomeDBiA1EHR5

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PRINTSiPR01333 2POREKCHANEL

Sequencei

Sequence statusi: Complete.

A1EHR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDEVRSFCL KFTTFVKSAT IFTITHVGLC FLVALYAVAG AFMFQAVEYP
60 70 80 90 100
YELGLQGKVK NASLKVVDDI YRFINRKNVI EETAVKNESQ WALKEFEMLL
110 120 130 140 150
VHAMNFEGYD EHDEERPTFQ WTFSGALLYS ITVFTTIGYG HICPKTDTGR
160 170 180 190 200
LLTILYSILG IPLMLLCLAN IAETLAQVFT YIYFKLCCAY CRWQKNRRRV
210 220 230 240 250
RRAALSFRYH PNAAVNVRRV QSSRSNQRYN TVRRHASLNR SRTRSNDTKS
260 270 280 290 300
VRSFNRYDST NTQPVQPPRF DTMSLPGRRK ISTQSRSPNG TMPRLPNFPQ
310 320 330 340 350
PKRGAHLQKS NTAINMEQLY TDEKRSRRGR HAVSESPARE YKGGLLVRAQ
360 370 380 390 400
HQPDEGVVDL KAYGGSAAAF HDLVTRKPRR DDAAVPNVII SRTRDEDVKS
410 420 430 440 450
DPDKTEETSM SLTDDEDMQK PPRRNNSARE LREKEMMMMN SLNHKQPSMD
460 470 480 490 500
SSTSRRLRDI DGRSYRSDRS ERSDEMSLHS LRRNGHRNQE KMPVSVGICI
510 520 530 540 550
VFAFISGGAW LFSWWENWNG FDGAYYCFIT LSTIGFGDIV PGQALDEGSQ
560 570 580 590 600
EKLVVCALYL LFGMALIAMC FKLMQDDVVQ KARWLGQKIG ILARPFELSR
610 620 630 640 650
EIAKHAIFLF GYSVSIRDES SESESDFDDD MIEEDEEDMS EERNDQVYDK
660 670
RTISSGSSKQ NEEYIHPRKY HHHHRR
Length:676
Mass (Da):77,929
Last modified:January 23, 2007 - v1
Checksum:iE2DE78B73E6EE7B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CAL90887.1
RefSeqiNP_001076639.1, NM_001083170.1
UniGeneiCel.10806

Genome annotation databases

EnsemblMetazoaiC24H11.8b; C24H11.8b; WBGene00006690
GeneIDi182864
KEGGicel:CELE_C24H11.8
UCSCiC24H11.8b c. elegans

Similar proteinsi

Entry informationi

Entry nameiA1EHR5_CAEEL
AccessioniPrimary (citable) accession number: A1EHR5
Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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