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Protein
Submitted name:

TWiK family of potassium channels

Gene

twk-39

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-1299344. TWIK-related spinal cord K+ channel (TRESK).

Names & Taxonomyi

Protein namesi
Submitted name:
TWiK family of potassium channelsImported
Gene namesi
Name:twk-39Imported
ORF Names:C24H11.8Imported, CELE_C24H11.8Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC24H11.8b; CE40599; WBGene00006690; twk-39.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4424HelicalSequence analysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence analysisAdd
BLAST
Transmembranei151 – 17222HelicalSequence analysisAdd
BLAST
Transmembranei178 – 19316HelicalSequence analysisAdd
BLAST
Transmembranei492 – 51120HelicalSequence analysisAdd
BLAST
Transmembranei553 – 57422HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiA1EHR5.

Expressioni

Gene expression databases

BgeeiWBGene00006690.
ExpressionAtlasiA1EHR5. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.C24H11.8b.

Structurei

3D structure databases

ProteinModelPortaliA1EHR5.
SMRiA1EHR5. Positions 36-201, 494-569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 17661Ion_trans_2InterPro annotationAdd
BLAST
Domaini499 – 57678Ion_trans_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000217931.
InParanoidiA1EHR5.
KOiK05323.
OMAiSPAREYK.
OrthoDBiEOG091G03S1.
PhylomeDBiA1EHR5.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.

Sequencei

Sequence statusi: Complete.

A1EHR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDEVRSFCL KFTTFVKSAT IFTITHVGLC FLVALYAVAG AFMFQAVEYP
60 70 80 90 100
YELGLQGKVK NASLKVVDDI YRFINRKNVI EETAVKNESQ WALKEFEMLL
110 120 130 140 150
VHAMNFEGYD EHDEERPTFQ WTFSGALLYS ITVFTTIGYG HICPKTDTGR
160 170 180 190 200
LLTILYSILG IPLMLLCLAN IAETLAQVFT YIYFKLCCAY CRWQKNRRRV
210 220 230 240 250
RRAALSFRYH PNAAVNVRRV QSSRSNQRYN TVRRHASLNR SRTRSNDTKS
260 270 280 290 300
VRSFNRYDST NTQPVQPPRF DTMSLPGRRK ISTQSRSPNG TMPRLPNFPQ
310 320 330 340 350
PKRGAHLQKS NTAINMEQLY TDEKRSRRGR HAVSESPARE YKGGLLVRAQ
360 370 380 390 400
HQPDEGVVDL KAYGGSAAAF HDLVTRKPRR DDAAVPNVII SRTRDEDVKS
410 420 430 440 450
DPDKTEETSM SLTDDEDMQK PPRRNNSARE LREKEMMMMN SLNHKQPSMD
460 470 480 490 500
SSTSRRLRDI DGRSYRSDRS ERSDEMSLHS LRRNGHRNQE KMPVSVGICI
510 520 530 540 550
VFAFISGGAW LFSWWENWNG FDGAYYCFIT LSTIGFGDIV PGQALDEGSQ
560 570 580 590 600
EKLVVCALYL LFGMALIAMC FKLMQDDVVQ KARWLGQKIG ILARPFELSR
610 620 630 640 650
EIAKHAIFLF GYSVSIRDES SESESDFDDD MIEEDEEDMS EERNDQVYDK
660 670
RTISSGSSKQ NEEYIHPRKY HHHHRR
Length:676
Mass (Da):77,929
Last modified:January 23, 2007 - v1
Checksum:iE2DE78B73E6EE7B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAL90887.1.
RefSeqiNP_001076639.1. NM_001083170.1.
UniGeneiCel.10806.

Genome annotation databases

EnsemblMetazoaiC24H11.8b; C24H11.8b; WBGene00006690.
GeneIDi182864.
KEGGicel:CELE_C24H11.8.
UCSCiC24H11.8b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAL90887.1.
RefSeqiNP_001076639.1. NM_001083170.1.
UniGeneiCel.10806.

3D structure databases

ProteinModelPortaliA1EHR5.
SMRiA1EHR5. Positions 36-201, 494-569.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C24H11.8b.

Proteomic databases

PaxDbiA1EHR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC24H11.8b; C24H11.8b; WBGene00006690.
GeneIDi182864.
KEGGicel:CELE_C24H11.8.
UCSCiC24H11.8b. c. elegans.

Organism-specific databases

CTDi182864.
WormBaseiC24H11.8b; CE40599; WBGene00006690; twk-39.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000217931.
InParanoidiA1EHR5.
KOiK05323.
OMAiSPAREYK.
OrthoDBiEOG091G03S1.
PhylomeDBiA1EHR5.

Enzyme and pathway databases

ReactomeiR-CEL-1299344. TWIK-related spinal cord K+ channel (TRESK).

Gene expression databases

BgeeiWBGene00006690.
ExpressionAtlasiA1EHR5. baseline.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
ProtoNetiSearch...

Entry informationi

Entry nameiA1EHR5_CAEEL
AccessioniPrimary (citable) accession number: A1EHR5
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.