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Protein
Submitted name:

TWiK family of potassium channels

Gene

twk-39

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotationImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-1299344. TWIK-related spinal cord K+ channel (TRESK).

Names & Taxonomyi

Protein namesi
Submitted name:
TWiK family of potassium channelsImported
Gene namesi
Name:twk-39Imported
ORF Names:C24H11.8Imported, CELE_C24H11.8Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC24H11.8b; CE40599; WBGene00006690; twk-39.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 44HelicalSequence analysisAdd BLAST24
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei151 – 172HelicalSequence analysisAdd BLAST22
Transmembranei178 – 193HelicalSequence analysisAdd BLAST16
Transmembranei492 – 511HelicalSequence analysisAdd BLAST20
Transmembranei553 – 574HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiA1EHR5.

Expressioni

Gene expression databases

BgeeiWBGene00006690.
ExpressionAtlasiA1EHR5. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.C24H11.8b.

Structurei

3D structure databases

ProteinModelPortaliA1EHR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 175Ion_trans_2InterPro annotationAdd BLAST60
Domaini501 – 576Ion_trans_2InterPro annotationAdd BLAST76

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00700000104522.
HOGENOMiHOG000217931.
InParanoidiA1EHR5.
KOiK05323.
OMAiISPRTDW.
OrthoDBiEOG091G03S1.
PhylomeDBiA1EHR5.

Family and domain databases

InterProiView protein in InterPro
IPR003280. 2pore_dom_K_chnl.
IPR013099. K_chnl_dom.
PfamiView protein in Pfam
PF07885. Ion_trans_2. 2 hits.
PRINTSiPR01333. 2POREKCHANEL.

Sequencei

Sequence statusi: Complete.

A1EHR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDEVRSFCL KFTTFVKSAT IFTITHVGLC FLVALYAVAG AFMFQAVEYP
60 70 80 90 100
YELGLQGKVK NASLKVVDDI YRFINRKNVI EETAVKNESQ WALKEFEMLL
110 120 130 140 150
VHAMNFEGYD EHDEERPTFQ WTFSGALLYS ITVFTTIGYG HICPKTDTGR
160 170 180 190 200
LLTILYSILG IPLMLLCLAN IAETLAQVFT YIYFKLCCAY CRWQKNRRRV
210 220 230 240 250
RRAALSFRYH PNAAVNVRRV QSSRSNQRYN TVRRHASLNR SRTRSNDTKS
260 270 280 290 300
VRSFNRYDST NTQPVQPPRF DTMSLPGRRK ISTQSRSPNG TMPRLPNFPQ
310 320 330 340 350
PKRGAHLQKS NTAINMEQLY TDEKRSRRGR HAVSESPARE YKGGLLVRAQ
360 370 380 390 400
HQPDEGVVDL KAYGGSAAAF HDLVTRKPRR DDAAVPNVII SRTRDEDVKS
410 420 430 440 450
DPDKTEETSM SLTDDEDMQK PPRRNNSARE LREKEMMMMN SLNHKQPSMD
460 470 480 490 500
SSTSRRLRDI DGRSYRSDRS ERSDEMSLHS LRRNGHRNQE KMPVSVGICI
510 520 530 540 550
VFAFISGGAW LFSWWENWNG FDGAYYCFIT LSTIGFGDIV PGQALDEGSQ
560 570 580 590 600
EKLVVCALYL LFGMALIAMC FKLMQDDVVQ KARWLGQKIG ILARPFELSR
610 620 630 640 650
EIAKHAIFLF GYSVSIRDES SESESDFDDD MIEEDEEDMS EERNDQVYDK
660 670
RTISSGSSKQ NEEYIHPRKY HHHHRR
Length:676
Mass (Da):77,929
Last modified:January 23, 2007 - v1
Checksum:iE2DE78B73E6EE7B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CAL90887.1.
RefSeqiNP_001076639.1. NM_001083170.1.
UniGeneiCel.10806.

Genome annotation databases

EnsemblMetazoaiC24H11.8b; C24H11.8b; WBGene00006690.
GeneIDi182864.
KEGGicel:CELE_C24H11.8.
UCSCiC24H11.8b. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA1EHR5_CAEEL
AccessioniPrimary (citable) accession number: A1EHR5
Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: July 5, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported