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Protein

HEAT repeat-containing protein 6

Gene

Heatr6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
HEAT repeat-containing protein 6
Gene namesi
Name:Heatr6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1566204. Heatr6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12521252HEAT repeat-containing protein 6PRO_0000337176Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei471 – 4711PhosphoserineBy similarity
Modified residuei474 – 4741PhosphoserineBy similarity
Modified residuei689 – 6891PhosphothreonineCombined sources
Modified residuei714 – 7141PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA1EC95.
PeptideAtlasiA1EC95.
PRIDEiA1EC95.

PTM databases

iPTMnetiA1EC95.
PhosphoSiteiA1EC95.

Expressioni

Gene expression databases

GenevisibleiA1EC95. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003492.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati230 – 26940HEAT 1Add
BLAST
Repeati524 – 56239HEAT 2Add
BLAST
Repeati586 – 62439HEAT 3Add
BLAST
Repeati630 – 66738HEAT 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi386 – 39611Poly-LysAdd
BLAST

Sequence similaritiesi

Contains 4 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4535. Eukaryota.
ENOG410XNWJ. LUCA.
GeneTreeiENSGT00390000016675.
HOGENOMiHOG000112878.
HOVERGENiHBG057052.
InParanoidiA1EC95.
OMAiQQCSSWT.
OrthoDBiEOG771269.
PhylomeDBiA1EC95.
TreeFamiTF324244.

Family and domain databases

Gene3Di1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR025283. DUF4042.
[Graphical view]
PfamiPF13251. DUF4042. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequencei

Sequence statusi: Complete.

A1EC95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALPGSKLS ERVRTVGWQI SRPYFCHFFP IRITAPPATC SANKGFPELE
60 70 80 90 100
HARPCPKRCP GSISQAIHVG KMAAVQVAAS LPCEQPREAP RELSLEQNNG
110 120 130 140 150
FRRLSARLRA LQPDDSTVSR MEIHLLFDQL ISENYCEGGG VAPEDVSALL
160 170 180 190 200
VRACQLVPLN QNHLVSKVSQ LIHRLLNRLQ VIVDEQNLDF LLTYTISAIQ
210 220 230 240 250
QCSPWTHMEI LQALAALVYC NGSKCQKHLP DLLGKSGLLM KLSDVTHSDP
260 270 280 290 300
EVRRAAVHCM ANLCLSVPGQ PYLEESYQLV CFQAFLTILQ SPKSSDMDDI
310 320 330 340 350
TFCMLLQNAL KGIQSLLNGG KMRLTQTEHL GALLAVLKKA MFHGLPGLNI
360 370 380 390 400
EMPAVLYPTP LPQYDGRSPV KPQQPESSAA RPSANKKKKY KVKPKKTQQG
410 420 430 440 450
EKAEEEEPYG EVDAAPGLSM DQANTCVESA WCSSPWGSQG LPVDGGRATG
460 470 480 490 500
REQVSSPFTI SSWKRVSSSE SDYSDAEGGM QGKMRSYQAK VRQGALACFL
510 520 530 540 550
STIKSIEKKV LYGYWSAFVP DTPELGSPQS VSLMTLTLKD PSPKTRACAL
560 570 580 590 600
QVLSAILEGS KQFLSVAEDT SDHKRAFTPF SVTIASSIRE LHRCLLLALV
610 620 630 640 650
AESSSQTLTQ IIKCLANLVS NAPYNRLKLS LLTKVWNHIK PYIRHKDVNV
660 670 680 690 700
RVSSLTLLGA VVSTHAPLPE VQLLLQQPCS SGRSSSSATP HLSTPDGWKA
710 720 730 740 750
LPAGPSLEEA SLSSPKGTAE PCWLIRLCIS TVVLPKEDSC SGSDAGSALG
760 770 780 790 800
STYEPSPMRL EALQVLAHLA RGYFSMAQLY LMELGEVICK CMCEANPSIQ
810 820 830 840 850
LHGVKLLEEL GTGLIQQYKP DSSTAPEQRV PVHMVAMFWT AMLNGPLPRA
860 870 880 890 900
LQSTEHPTLQ ASACDALSSI LPEAFSSLPN DKQILCITML LGLNDSKNHL
910 920 930 940 950
VKAATSRALG VYVLFPCLRQ DVIFVADTAN AILMSLQDKS LNVRAKAAWS
960 970 980 990 1000
LGNLTDTLIV NMDTPDPSFQ DEFSGLLLLK MLQSAIQAST DKDKVKSNAV
1010 1020 1030 1040 1050
RALGNLLHFL QPSHIERPRF AEIIEESIQA LISTVVNEAA MKVRWNACYA
1060 1070 1080 1090 1100
MGNVFKNPAL PLGTAPWTSQ AYKALTSVVM SCKNFKVRIR SAAALSVPGR
1110 1120 1130 1140 1150
RAQYGSLEQF SQIWSALVTA LQRSEDTTDF LEFKYCASLR THVCQALLHL
1160 1170 1180 1190 1200
LGLASASDLP CIQETLTVNG DMIRSYILQF LKSGAGGDDP GAVHSPQERN
1210 1220 1230 1240 1250
QMVRVALRHI HSVQALAGDT AKGAIVGFLE DILTVHCDSS GERAVLRGSL

DQ
Length:1,252
Mass (Da):136,505
Last modified:January 23, 2007 - v1
Checksum:iE2A60C675685CF76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF122002 mRNA. Translation: ABL63441.1.
EF122003 mRNA. Translation: ABL63442.1.
RefSeqiNP_001073366.1. NM_001079897.1.
UniGeneiRn.27022.

Genome annotation databases

EnsembliENSRNOT00000003492; ENSRNOP00000003492; ENSRNOG00000002542.
GeneIDi497972.
KEGGirno:497972.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF122002 mRNA. Translation: ABL63441.1.
EF122003 mRNA. Translation: ABL63442.1.
RefSeqiNP_001073366.1. NM_001079897.1.
UniGeneiRn.27022.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003492.

PTM databases

iPTMnetiA1EC95.
PhosphoSiteiA1EC95.

Proteomic databases

PaxDbiA1EC95.
PeptideAtlasiA1EC95.
PRIDEiA1EC95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003492; ENSRNOP00000003492; ENSRNOG00000002542.
GeneIDi497972.
KEGGirno:497972.

Organism-specific databases

CTDi63897.
RGDi1566204. Heatr6.

Phylogenomic databases

eggNOGiKOG4535. Eukaryota.
ENOG410XNWJ. LUCA.
GeneTreeiENSGT00390000016675.
HOGENOMiHOG000112878.
HOVERGENiHBG057052.
InParanoidiA1EC95.
OMAiQQCSSWT.
OrthoDBiEOG771269.
PhylomeDBiA1EC95.
TreeFamiTF324244.

Miscellaneous databases

PROiA1EC95.

Gene expression databases

GenevisibleiA1EC95. RN.

Family and domain databases

Gene3Di1.25.10.10. 5 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR025283. DUF4042.
[Graphical view]
PfamiPF13251. DUF4042. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10."
    Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P., Radecki T., Joe B.
    Genomics 89:343-353(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Dahl salt-sensitive and Lewis.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-689 AND SER-714, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHEAT6_RAT
AccessioniPrimary (citable) accession number: A1EC95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.