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A1EC81

- A1EC81_RAT

UniProt

A1EC81 - A1EC81_RAT

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Protein
Submitted name:

Matrix metalloproteinase 28

Gene

Mmp28

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei241 – 2411UniRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. metalloendopeptidase activity Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, MetalloproteaseSAAS annotation, Protease

Keywords - Ligandi

CalciumSAAS annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

Protein family/group databases

MEROPSiM10.030.

Names & Taxonomyi

Protein namesi
Submitted name:
Matrix metalloproteinase 28Imported
Submitted name:
Protein LOC100912318Imported
Submitted name:
Protein Mmp28Imported
Gene namesi
Name:Mmp28Imported
Synonyms:LOC100912318Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi6487746. LOC100912318.
1311573. Mmp28.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriA1EC81.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013836.

Family & Domainsi

Sequence similaritiesi

Contains hemopexin repeats.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiNOG254923.
GeneTreeiENSGT00760000119132.
HOGENOMiHOG000217927.
HOVERGENiHBG052484.
KOiK08006.
OMAiFEAWDPH.
OrthoDBiEOG7XPZ57.
TreeFamiTF315428.

Family and domain databases

Gene3Di1.10.101.10. 1 hit.
2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR024079. MetalloPept_cat_dom.
IPR028735. MMP28.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PANTHERiPTHR10201:SF16. PTHR10201:SF16. 1 hit.
PfamiPF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiPS51642. HEMOPEXIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1EC81-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTGLSLLLR VLPLLLWGCQ DAQPTPRGHP ELHQEAEAFL EKYGYLSEQG
60 70 80 90 100
SKVPASTQFS DAIREFQWVS QLPISGVLDR ATLRQMTRPR CGVADTDSHE
110 120 130 140 150
TWTERIRALL AGHRAKMRRK KRFAKPGHKW YKQHLSYRLV NWPKSLPEPA
160 170 180 190 200
VRGAVRAAFQ LWSNVSALEF WEAPATGPAD IRLTFFQGDH NDGLANAFDG
210 220 230 240 250
PGGALAHAFL PRRGEAHFDQ DERWSLSRRR GRNLFVVLAH EIGHTLGLTH
260 270 280 290 300
SPAPRALMAP YYKKLGRDAL LSWDDVLAVQ NLYGKPLGRS VATQLPGKIF
310 320 330 340 350
TDFEAWDPHN SQSRRPETRG PKYCHSSFDA ITVDGQWRLY VFKGSHFWEV
360 370 380 390 400
TADGNVSEPH PLQKRWPGLP SSIEAAAVSL EDGDFFFFKG NRCWRFQGTK
410 420 430 440 450
SVFAQLCRAG GLPRHPDAAL FFPPLRRLVL FKGSRYYVLA RGGMQVEPYY
460 470 480 490 500
PRSLRDWAGV PEEVSGALPR PDGSIIFFRD DHYWHLDQAK LRVTSSGRWA
510 520
TELSWMGCWN ANSGGALFQR LPVTE
Length:525
Mass (Da):59,436
Last modified:January 23, 2007 - v1
Checksum:i5975E21F30768EB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06064900 Genomic DNA. No translation available.
AABR06064925 Genomic DNA. No translation available.
EF121988 mRNA. Translation: ABL63427.1.
RefSeqiNP_001073357.1. NM_001079888.1.
UniGeneiRn.60472.

Genome annotation databases

EnsembliENSRNOT00000013836; ENSRNOP00000013836; ENSRNOG00000047940.
ENSRNOT00000064937; ENSRNOP00000060554; ENSRNOG00000048414.
GeneIDi303384.
KEGGirno:100912318.
rno:303384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06064900 Genomic DNA. No translation available.
AABR06064925 Genomic DNA. No translation available.
EF121988 mRNA. Translation: ABL63427.1 .
RefSeqi NP_001073357.1. NM_001079888.1.
UniGenei Rn.60472.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000013836.

Protein family/group databases

MEROPSi M10.030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000013836 ; ENSRNOP00000013836 ; ENSRNOG00000047940 .
ENSRNOT00000064937 ; ENSRNOP00000060554 ; ENSRNOG00000048414 .
GeneIDi 303384.
KEGGi rno:100912318.
rno:303384.

Organism-specific databases

CTDi 79148.
RGDi 6487746. LOC100912318.
1311573. Mmp28.

Phylogenomic databases

eggNOGi NOG254923.
GeneTreei ENSGT00760000119132.
HOGENOMi HOG000217927.
HOVERGENi HBG052484.
KOi K08006.
OMAi FEAWDPH.
OrthoDBi EOG7XPZ57.
TreeFami TF315428.

Miscellaneous databases

NextBioi 651262.
PROi A1EC81.

Gene expression databases

Genevestigatori A1EC81.

Family and domain databases

Gene3Di 1.10.101.10. 1 hit.
2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR024079. MetalloPept_cat_dom.
IPR028735. MMP28.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view ]
PANTHERi PTHR10201:SF16. PTHR10201:SF16. 1 hit.
Pfami PF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSi PR00138. MATRIXIN.
SMARTi SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view ]
SUPFAMi SSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEi PS51642. HEMOPEXIN_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10."
    Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P., Radecki T., Joe B.
    Genomics 89:343-353(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSSImported.
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiA1EC81_RAT
AccessioniPrimary (citable) accession number: A1EC81
Secondary accession number(s): D3ZNN5
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3