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Protein
Submitted name:

Matrix metalloproteinase 28

Gene

Mmp28

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei241 – 2411UniRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. metalloendopeptidase activity Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, MetalloproteaseSAAS annotation, Protease

Keywords - Ligandi

CalciumSAAS annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

Protein family/group databases

MEROPSiM10.030.

Names & Taxonomyi

Protein namesi
Submitted name:
Matrix metalloproteinase 28Imported
Submitted name:
Protein LOC100912318Imported
Gene namesi
Name:Mmp28Imported
Synonyms:LOC100912318Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi6487746. LOC100912318.
1311573. Mmp28.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiA1EC81.

Expressioni

Gene expression databases

GenevestigatoriA1EC81.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013836.

Structurei

3D structure databases

ProteinModelPortaliA1EC81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiNOG254923.
GeneTreeiENSGT00760000119132.
HOGENOMiHOG000217927.
HOVERGENiHBG052484.
InParanoidiA1EC81.
KOiK08006.
OMAiFEAWDPH.
OrthoDBiEOG7XPZ57.
TreeFamiTF315428.

Family and domain databases

Gene3Di1.10.101.10. 1 hit.
2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR024079. MetalloPept_cat_dom.
IPR028735. MMP28.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PANTHERiPTHR10201:SF16. PTHR10201:SF16. 1 hit.
PfamiPF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiPS51642. HEMOPEXIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1EC81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTGLSLLLR VLPLLLWGCQ DAQPTPRGHP ELHQEAEAFL EKYGYLSEQG
60 70 80 90 100
SKVPASTQFS DAIREFQWVS QLPISGVLDR ATLRQMTRPR CGVADTDSHE
110 120 130 140 150
TWTERIRALL AGHRAKMRRK KRFAKPGHKW YKQHLSYRLV NWPKSLPEPA
160 170 180 190 200
VRGAVRAAFQ LWSNVSALEF WEAPATGPAD IRLTFFQGDH NDGLANAFDG
210 220 230 240 250
PGGALAHAFL PRRGEAHFDQ DERWSLSRRR GRNLFVVLAH EIGHTLGLTH
260 270 280 290 300
SPAPRALMAP YYKKLGRDAL LSWDDVLAVQ NLYGKPLGRS VATQLPGKIF
310 320 330 340 350
TDFEAWDPHN SQSRRPETRG PKYCHSSFDA ITVDGQWRLY VFKGSHFWEV
360 370 380 390 400
TADGNVSEPH PLQKRWPGLP SSIEAAAVSL EDGDFFFFKG NRCWRFQGTK
410 420 430 440 450
SVFAQLCRAG GLPRHPDAAL FFPPLRRLVL FKGSRYYVLA RGGMQVEPYY
460 470 480 490 500
PRSLRDWAGV PEEVSGALPR PDGSIIFFRD DHYWHLDQAK LRVTSSGRWA
510 520
TELSWMGCWN ANSGGALFQR LPVTE
Length:525
Mass (Da):59,436
Last modified:January 23, 2007 - v1
Checksum:i5975E21F30768EB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06064900 Genomic DNA. No translation available.
AABR06064925 Genomic DNA. No translation available.
EF121988 mRNA. Translation: ABL63427.1.
RefSeqiNP_001073357.1. NM_001079888.1.
XP_008772033.1. XM_008773811.1.
UniGeneiRn.60472.

Genome annotation databases

EnsembliENSRNOT00000013836; ENSRNOP00000013836; ENSRNOG00000047940.
ENSRNOT00000064937; ENSRNOP00000060554; ENSRNOG00000048414.
GeneIDi103694864.
303384.
KEGGirno:103694864.
rno:303384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06064900 Genomic DNA. No translation available.
AABR06064925 Genomic DNA. No translation available.
EF121988 mRNA. Translation: ABL63427.1.
RefSeqiNP_001073357.1. NM_001079888.1.
XP_008772033.1. XM_008773811.1.
UniGeneiRn.60472.

3D structure databases

ProteinModelPortaliA1EC81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013836.

Protein family/group databases

MEROPSiM10.030.

Proteomic databases

PaxDbiA1EC81.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013836; ENSRNOP00000013836; ENSRNOG00000047940.
ENSRNOT00000064937; ENSRNOP00000060554; ENSRNOG00000048414.
GeneIDi103694864.
303384.
KEGGirno:103694864.
rno:303384.

Organism-specific databases

CTDi79148.
RGDi6487746. LOC100912318.
1311573. Mmp28.

Phylogenomic databases

eggNOGiNOG254923.
GeneTreeiENSGT00760000119132.
HOGENOMiHOG000217927.
HOVERGENiHBG052484.
InParanoidiA1EC81.
KOiK08006.
OMAiFEAWDPH.
OrthoDBiEOG7XPZ57.
TreeFamiTF315428.

Miscellaneous databases

NextBioi35568979.
PROiA1EC81.

Gene expression databases

GenevestigatoriA1EC81.

Family and domain databases

Gene3Di1.10.101.10. 1 hit.
2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR024079. MetalloPept_cat_dom.
IPR028735. MMP28.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
[Graphical view]
PANTHERiPTHR10201:SF16. PTHR10201:SF16. 1 hit.
PfamiPF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiPS51642. HEMOPEXIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10."
    Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P., Radecki T., Joe B.
    Genomics 89:343-353(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSSImported.
  3. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.
  4. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiA1EC81_RAT
AccessioniPrimary (citable) accession number: A1EC81
Secondary accession number(s): D3ZNN5
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.