Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1EC81

- A1EC81_RAT

UniProt

A1EC81 - A1EC81_RAT

Protein
Submitted name:

Matrix metalloproteinase 28

Gene

Mmp28

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei241 – 2411UniRule annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. metalloendopeptidase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, MetalloproteaseSAAS annotation, Protease

    Keywords - Ligandi

    CalciumSAAS annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

    Protein family/group databases

    MEROPSiM10.030.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Matrix metalloproteinase 28Imported
    Submitted name:
    Protein Mmp28Imported
    Gene namesi
    Name:Mmp28Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi1311573. Mmp28.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: InterPro

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriA1EC81.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000013836.

    Family & Domainsi

    Sequence similaritiesi

    Contains hemopexin repeats.SAAS annotation

    Keywords - Domaini

    RepeatSAAS annotation

    Phylogenomic databases

    eggNOGiNOG254923.
    GeneTreeiENSGT00730000110806.
    HOGENOMiHOG000217927.
    HOVERGENiHBG052484.
    InParanoidiA1EC81.
    KOiK08006.
    OMAiFEAWDPH.
    OrthoDBiEOG7XPZ57.
    TreeFamiTF315428.

    Family and domain databases

    Gene3Di1.10.101.10. 1 hit.
    2.110.10.10. 1 hit.
    3.40.390.10. 1 hit.
    InterProiIPR000585. Hemopexin-like_dom.
    IPR018487. Hemopexin-like_repeat.
    IPR024079. MetalloPept_cat_dom.
    IPR028735. MMP28.
    IPR001818. Pept_M10_metallopeptidase.
    IPR021190. Pept_M10A.
    IPR016293. Pept_M10A_stromelysin-type.
    IPR006026. Peptidase_Metallo.
    IPR002477. Peptidoglycan-bd-like.
    [Graphical view]
    PANTHERiPTHR10201:SF16. PTHR10201:SF16. 1 hit.
    PfamiPF00045. Hemopexin. 3 hits.
    PF00413. Peptidase_M10. 1 hit.
    PF01471. PG_binding_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
    PRINTSiPR00138. MATRIXIN.
    SMARTiSM00120. HX. 4 hits.
    SM00235. ZnMc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47090. SSF47090. 1 hit.
    SSF50923. SSF50923. 1 hit.
    PROSITEiPS51642. HEMOPEXIN_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1EC81-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTGLSLLLR VLPLLLWGCQ DAQPTPRGHP ELHQEAEAFL EKYGYLSEQG    50
    SKVPASTQFS DAIREFQWVS QLPISGVLDR ATLRQMTRPR CGVADTDSHE 100
    TWTERIRALL AGHRAKMRRK KRFAKPGHKW YKQHLSYRLV NWPKSLPEPA 150
    VRGAVRAAFQ LWSNVSALEF WEAPATGPAD IRLTFFQGDH NDGLANAFDG 200
    PGGALAHAFL PRRGEAHFDQ DERWSLSRRR GRNLFVVLAH EIGHTLGLTH 250
    SPAPRALMAP YYKKLGRDAL LSWDDVLAVQ NLYGKPLGRS VATQLPGKIF 300
    TDFEAWDPHN SQSRRPETRG PKYCHSSFDA ITVDGQWRLY VFKGSHFWEV 350
    TADGNVSEPH PLQKRWPGLP SSIEAAAVSL EDGDFFFFKG NRCWRFQGTK 400
    SVFAQLCRAG GLPRHPDAAL FFPPLRRLVL FKGSRYYVLA RGGMQVEPYY 450
    PRSLRDWAGV PEEVSGALPR PDGSIIFFRD DHYWHLDQAK LRVTSSGRWA 500
    TELSWMGCWN ANSGGALFQR LPVTE 525
    Length:525
    Mass (Da):59,436
    Last modified:January 23, 2007 - v1
    Checksum:i5975E21F30768EB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06064900 Genomic DNA. No translation available.
    AABR06064925 Genomic DNA. No translation available.
    EF121988 mRNA. Translation: ABL63427.1.
    RefSeqiNP_001073357.1. NM_001079888.1.
    XP_003750927.1. XM_003750879.2.
    UniGeneiRn.60472.

    Genome annotation databases

    EnsembliENSRNOT00000013836; ENSRNOP00000013836; ENSRNOG00000047940.
    ENSRNOT00000064937; ENSRNOP00000060554; ENSRNOG00000048414.
    GeneIDi100912318.
    303384.
    KEGGirno:100912318.
    rno:303384.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06064900 Genomic DNA. No translation available.
    AABR06064925 Genomic DNA. No translation available.
    EF121988 mRNA. Translation: ABL63427.1 .
    RefSeqi NP_001073357.1. NM_001079888.1.
    XP_003750927.1. XM_003750879.2.
    UniGenei Rn.60472.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000013836.

    Protein family/group databases

    MEROPSi M10.030.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000013836 ; ENSRNOP00000013836 ; ENSRNOG00000047940 .
    ENSRNOT00000064937 ; ENSRNOP00000060554 ; ENSRNOG00000048414 .
    GeneIDi 100912318.
    303384.
    KEGGi rno:100912318.
    rno:303384.

    Organism-specific databases

    CTDi 79148.
    RGDi 1311573. Mmp28.

    Phylogenomic databases

    eggNOGi NOG254923.
    GeneTreei ENSGT00730000110806.
    HOGENOMi HOG000217927.
    HOVERGENi HBG052484.
    InParanoidi A1EC81.
    KOi K08006.
    OMAi FEAWDPH.
    OrthoDBi EOG7XPZ57.
    TreeFami TF315428.

    Miscellaneous databases

    NextBioi 651262.
    PROi A1EC81.

    Gene expression databases

    Genevestigatori A1EC81.

    Family and domain databases

    Gene3Di 1.10.101.10. 1 hit.
    2.110.10.10. 1 hit.
    3.40.390.10. 1 hit.
    InterProi IPR000585. Hemopexin-like_dom.
    IPR018487. Hemopexin-like_repeat.
    IPR024079. MetalloPept_cat_dom.
    IPR028735. MMP28.
    IPR001818. Pept_M10_metallopeptidase.
    IPR021190. Pept_M10A.
    IPR016293. Pept_M10A_stromelysin-type.
    IPR006026. Peptidase_Metallo.
    IPR002477. Peptidoglycan-bd-like.
    [Graphical view ]
    PANTHERi PTHR10201:SF16. PTHR10201:SF16. 1 hit.
    Pfami PF00045. Hemopexin. 3 hits.
    PF00413. Peptidase_M10. 1 hit.
    PF01471. PG_binding_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001191. Peptidase_M10A_matrix. 1 hit.
    PRINTSi PR00138. MATRIXIN.
    SMARTi SM00120. HX. 4 hits.
    SM00235. ZnMc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47090. SSF47090. 1 hit.
    SSF50923. SSF50923. 1 hit.
    PROSITEi PS51642. HEMOPEXIN_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10."
      Saad Y., Garrett M.R., Manickavasagam E., Yerga-Woolwine S., Farms P., Radecki T., Joe B.
      Genomics 89:343-353(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DSSImported.
    3. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.
    4. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiA1EC81_RAT
    AccessioniPrimary (citable) accession number: A1EC81
    Secondary accession number(s): D3ZNN5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3