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Protein
Submitted name:

Matrix metalloproteinase 28

Gene

Mmp28

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei241UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, MetalloproteaseSAAS annotation, Protease
LigandCalciumSAAS annotation, Metal-bindingSAAS annotation, ZincSAAS annotation

Protein family/group databases

MEROPSiM10.030.

Names & Taxonomyi

Protein namesi
Submitted name:
Matrix metalloproteinase 28Imported
Submitted name:
Matrix metalloproteinase-28-likeImported
Gene namesi
Name:Mmp28Imported
Synonyms:LOC100912318Imported, LOC103694864Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi9149208. LOC103694864.
1311573. Mmp28.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500968226723 – 525Sequence analysisAdd BLAST503

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000047940.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060554.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 285ZnMcInterPro annotationAdd BLAST160

Sequence similaritiesi

Belongs to the peptidase M10A family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00870000136399.
HOGENOMiHOG000217927.
HOVERGENiHBG052484.
KOiK08006.
OMAiFEAWDPH.
OrthoDBiEOG091G03DP.
TreeFamiTF315428.

Family and domain databases

CDDicd00094. HX. 1 hit.
cd04278. ZnMc_MMP. 1 hit.
Gene3Di1.10.101.10. 1 hit.
2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom.
IPR028735. MMP28.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
PANTHERiPTHR10201:SF178. PTHR10201:SF178. 1 hit.
PfamiView protein in Pfam
PF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiView protein in SMART
SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiView protein in PROSITE
PS51642. HEMOPEXIN_2. 3 hits.

Sequencei

Sequence statusi: Complete.

A1EC81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTGLSLLLR VLPLLLWGCQ DAQPTPRGHP ELHQEAEAFL EKYGYLSEQG
60 70 80 90 100
SKVPASTQFS DAIREFQWVS QLPISGVLDR ATLRQMTRPR CGVADTDSHE
110 120 130 140 150
TWTERIRALL AGHRAKMRRK KRFAKPGHKW YKQHLSYRLV NWPKSLPEPA
160 170 180 190 200
VRGAVRAAFQ LWSNVSALEF WEAPATGPAD IRLTFFQGDH NDGLANAFDG
210 220 230 240 250
PGGALAHAFL PRRGEAHFDQ DERWSLSRRR GRNLFVVLAH EIGHTLGLTH
260 270 280 290 300
SPAPRALMAP YYKKLGRDAL LSWDDVLAVQ NLYGKPLGRS VATQLPGKIF
310 320 330 340 350
TDFEAWDPHN SQSRRPETRG PKYCHSSFDA ITVDGQWRLY VFKGSHFWEV
360 370 380 390 400
TADGNVSEPH PLQKRWPGLP SSIEAAAVSL EDGDFFFFKG NRCWRFQGTK
410 420 430 440 450
SVFAQLCRAG GLPRHPDAAL FFPPLRRLVL FKGSRYYVLA RGGMQVEPYY
460 470 480 490 500
PRSLRDWAGV PEEVSGALPR PDGSIIFFRD DHYWHLDQAK LRVTSSGRWA
510 520
TELSWMGCWN ANSGGALFQR LPVTE
Length:525
Mass (Da):59,436
Last modified:January 23, 2007 - v1
Checksum:i5975E21F30768EB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119615 Genomic DNA. No translation available.
EF121988 mRNA. Translation: ABL63427.1.
RefSeqiNP_001073357.1. NM_001079888.1.
XP_008772033.1. XM_008773811.2.
UniGeneiRn.60472.

Genome annotation databases

EnsembliENSRNOT00000013836; ENSRNOP00000013836; ENSRNOG00000047940.
ENSRNOT00000083214; ENSRNOP00000075186; ENSRNOG00000061904.
GeneIDi103694864.
303384.
KEGGirno:103694864.
rno:303384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119615 Genomic DNA. No translation available.
EF121988 mRNA. Translation: ABL63427.1.
RefSeqiNP_001073357.1. NM_001079888.1.
XP_008772033.1. XM_008773811.2.
UniGeneiRn.60472.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060554.

Protein family/group databases

MEROPSiM10.030.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013836; ENSRNOP00000013836; ENSRNOG00000047940.
ENSRNOT00000083214; ENSRNOP00000075186; ENSRNOG00000061904.
GeneIDi103694864.
303384.
KEGGirno:103694864.
rno:303384.

Organism-specific databases

CTDi79148.
RGDi9149208. LOC103694864.
1311573. Mmp28.

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00870000136399.
HOGENOMiHOG000217927.
HOVERGENiHBG052484.
KOiK08006.
OMAiFEAWDPH.
OrthoDBiEOG091G03DP.
TreeFamiTF315428.

Gene expression databases

BgeeiENSRNOG00000047940.

Family and domain databases

CDDicd00094. HX. 1 hit.
cd04278. ZnMc_MMP. 1 hit.
Gene3Di1.10.101.10. 1 hit.
2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR033739. M10A_MMP.
IPR024079. MetalloPept_cat_dom.
IPR028735. MMP28.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR002477. Peptidoglycan-bd-like.
PANTHERiPTHR10201:SF178. PTHR10201:SF178. 1 hit.
PfamiView protein in Pfam
PF00045. Hemopexin. 3 hits.
PF00413. Peptidase_M10. 1 hit.
PF01471. PG_binding_1. 1 hit.
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiView protein in SMART
SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
SUPFAMiSSF47090. SSF47090. 1 hit.
SSF50923. SSF50923. 1 hit.
PROSITEiView protein in PROSITE
PS51642. HEMOPEXIN_2. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiA1EC81_RAT
AccessioniPrimary (citable) accession number: A1EC81
Secondary accession number(s): D3ZNN5
Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.