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Protein
Submitted name:

Checkpoint and tumor suppressor protein 2

Gene

CHEK2

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-GGA-351433. ATM mediated phosphorylation of repair proteins.
R-GGA-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-GGA-6804757. Regulation of TP53 Degradation.
R-GGA-69473. G2/M DNA damage checkpoint.
R-GGA-69541. Stabilization of p53.
R-GGA-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Names & Taxonomyi

Protein namesi
Submitted name:
Checkpoint and tumor suppressor protein 2Imported
Submitted name:
Checkpoint kinase 2Imported
Gene namesi
Name:CHEK2Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSGALG00000005695.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000009122.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 152FHAInterPro annotationAdd BLAST63
Domaini197 – 463Protein kinaseInterPro annotationAdd BLAST267

Phylogenomic databases

eggNOGiKOG0615. Eukaryota.
ENOG410YA63. LUCA.
GeneTreeiENSGT00800000124190.
HOGENOMiHOG000233016.
HOVERGENiHBG108055.
KOiK06641.
OrthoDBiEOG091G0DVW.
TreeFamiTF101082.

Family and domain databases

CDDicd00060. FHA. 1 hit.
InterProiView protein in InterPro
IPR000253. FHA_dom.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR008984. SMAD_FHA_dom_sf.
PfamiView protein in Pfam
PF00498. FHA. 1 hit.
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00240. FHA. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50006. FHA_DOMAIN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

A1EAT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRETRSDAQ PSQGTQPSQG GTSSSSSASQ GASQSSSSSG TLSSLDTVPT
60 70 80 90 100
QELPSIPEDP EPDELVPQPW GRLFALGKGF SNWDCVNDEY WFGRDKSCDY
110 120 130 140 150
SFSKLGLSET GFYQNYSKKH FRIFREMGPK NSYVAYIEDH SANGTFINRE
160 170 180 190 200
LIGKGKRLPL THNSEIALSI QTNKVFVFSD LTVDDQLVFP REFREKYIMS
210 220 230 240 250
KTLGSGACGE VKLAFEKSTC NKVAVKIINK RKFMASGGRE ANPAFNINTE
260 270 280 290 300
IEILKKIDHP CLIKIKNFFE AEDYYIVLEL MEGGELYDRV SRPVKMKEAT
310 320 330 340 350
CKLYFYQMLL AVKYLHDNGI IHRDLKPENV LLSSSEETCL IKITDFGQSK
360 370 380 390 400
ILGETSLMKT LCGTPTYLAP EVLNSFGTAG YSRAVDCWSL GVILFVCLCG
410 420 430 440 450
YPPFNEQNTQ LSLKDQITRG EYTFISKEWK HVSNMALDLV KKLLVVDPSK
460 470 480 490 500
RFTIEEALEH PWLQDEDMKN TFQQLLAQTS ATMNPPQTSK MPVATRKRLH
510 520
ENEDESVSSK RDVPSTSLQK MR
Length:522
Mass (Da):58,798
Last modified:January 23, 2007 - v1
Checksum:i76D413B18C360C96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000193 Genomic DNA. No translation available.
EF118300 mRNA. Translation: ABL14109.1.
RefSeqiNP_001073576.1. NM_001080107.1.
UniGeneiGga.2517.

Genome annotation databases

EnsembliENSGALT00000009136; ENSGALP00000009122; ENSGALG00000005695.
GeneIDi768913.
KEGGigga:768913.

Similar proteinsi

Entry informationi

Entry nameiA1EAT1_CHICK
AccessioniPrimary (citable) accession number: A1EAT1
Secondary accession number(s): F1N864
Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported