Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1E960

- ODAM_MOUSE

UniProt

A1E960 - ODAM_MOUSE

Protein

Odontogenic ameloblast-associated protein

Gene

Odam

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process By similarity.By similarity

    GO - Biological processi

    1. biomineral tissue development Source: UniProtKB-KW
    2. odontogenesis of dentin-containing tooth Source: Ensembl

    Keywords - Biological processi

    Biomineralization

    Enzyme and pathway databases

    ReactomeiREACT_198563. Amyloids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Odontogenic ameloblast-associated protein
    Alternative name(s):
    Apin
    Gene namesi
    Name:Odam
    Synonyms:Apin
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1916842. Odam.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular region Source: MGI
    3. fibril Source: Ensembl
    4. nucleus Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 273258Odontogenic ameloblast-associated proteinPRO_5000183880Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi114 – 1141O-linked (GalNAc...)Sequence Analysis
    Glycosylationi118 – 1181O-linked (GalNAc...)Sequence Analysis
    Glycosylationi159 – 1591O-linked (GalNAc...)Sequence Analysis
    Glycosylationi240 – 2401O-linked (GalNAc...)Sequence Analysis
    Glycosylationi241 – 2411O-linked (GalNAc...)Sequence Analysis
    Glycosylationi247 – 2471O-linked (GalNAc...)Sequence Analysis
    Glycosylationi252 – 2521O-linked (GalNAc...)Sequence Analysis
    Glycosylationi258 – 2581O-linked (GalNAc...)Sequence Analysis
    Glycosylationi267 – 2671O-linked (GalNAc...)Sequence Analysis

    Post-translational modificationi

    O-glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiA1E960.

    Expressioni

    Tissue specificityi

    Highly expressed in tooth-associated epithelia. Predominantly expressed in mandible.1 Publication

    Gene expression databases

    BgeeiA1E960.
    CleanExiMM_ODAM.
    GenevestigatoriA1E960.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000108899.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi62 – 196135Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ODAM family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG74202.
    GeneTreeiENSGT00390000011100.
    HOGENOMiHOG000115257.
    HOVERGENiHBG096669.
    InParanoidiA1E960.
    OMAiNSWIPPF.
    OrthoDBiEOG7673CG.
    PhylomeDBiA1E960.
    TreeFamiTF338424.

    Family and domain databases

    InterProiIPR026802. Odam.
    [Graphical view]
    PANTHERiPTHR16237. PTHR16237. 1 hit.
    PfamiPF15424. ODAM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1E960-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIIILLGLI GASSSAPLIS QRLLSASNSH ELLLNLNNGQ LLPLQFQGAF    50
    NSWIPPFPGF LQQQQAQVSG RPQFTLSTLE SFAGLFPNQI PLSRQVGLAQ 100
    GGQAGQPDLS QQQTPPQTQQ SASPMSYVVP VKVPQDQTQM FQYYPVYMLL 150
    PWEQPQTVTS SPQHTGQQLF EEQIPFYNQF GFAPPQAEPG VPGGQQHLAF 200
    DSFVGTAPET PGMPVEGSLL YPQKEPISFK HDNAGVFMPT TSPKPSTDNF 250
    FTSGIDPTIA PEQKVKTDSL REP 273
    Length:273
    Mass (Da):29,820
    Last modified:January 23, 2007 - v1
    Checksum:iCA8B395AE68985B6
    GO

    Sequence cautioni

    The sequence AAI32395.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI32397.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB26200.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF113909 mRNA. Translation: ABL11578.1.
    AK009298 mRNA. Translation: BAB26200.1. Different initiation.
    BC132394 mRNA. Translation: AAI32395.1. Different initiation.
    BC132396 mRNA. Translation: AAI32397.1. Different initiation.
    CCDSiCCDS19394.2.
    RefSeqiNP_081404.2. NM_027128.2.
    XP_006535273.1. XM_006535210.1.
    UniGeneiMm.389652.

    Genome annotation databases

    EnsembliENSMUST00000113274; ENSMUSP00000108899; ENSMUSG00000009580.
    ENSMUST00000129757; ENSMUSP00000117898; ENSMUSG00000009580.
    GeneIDi69592.
    KEGGimmu:69592.
    UCSCiuc008xzd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF113909 mRNA. Translation: ABL11578.1 .
    AK009298 mRNA. Translation: BAB26200.1 . Different initiation.
    BC132394 mRNA. Translation: AAI32395.1 . Different initiation.
    BC132396 mRNA. Translation: AAI32397.1 . Different initiation.
    CCDSi CCDS19394.2.
    RefSeqi NP_081404.2. NM_027128.2.
    XP_006535273.1. XM_006535210.1.
    UniGenei Mm.389652.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000108899.

    Proteomic databases

    PRIDEi A1E960.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000113274 ; ENSMUSP00000108899 ; ENSMUSG00000009580 .
    ENSMUST00000129757 ; ENSMUSP00000117898 ; ENSMUSG00000009580 .
    GeneIDi 69592.
    KEGGi mmu:69592.
    UCSCi uc008xzd.1. mouse.

    Organism-specific databases

    CTDi 54959.
    MGIi MGI:1916842. Odam.

    Phylogenomic databases

    eggNOGi NOG74202.
    GeneTreei ENSGT00390000011100.
    HOGENOMi HOG000115257.
    HOVERGENi HBG096669.
    InParanoidi A1E960.
    OMAi NSWIPPF.
    OrthoDBi EOG7673CG.
    PhylomeDBi A1E960.
    TreeFami TF338424.

    Enzyme and pathway databases

    Reactomei REACT_198563. Amyloids.

    Miscellaneous databases

    NextBioi 329866.
    PROi A1E960.
    SOURCEi Search...

    Gene expression databases

    Bgeei A1E960.
    CleanExi MM_ODAM.
    Genevestigatori A1E960.

    Family and domain databases

    InterProi IPR026802. Odam.
    [Graphical view ]
    PANTHERi PTHR16237. PTHR16237. 1 hit.
    Pfami PF15424. ODAM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Moffatt P., Smith C.E., Nanci A.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
      Tissue: Mandible.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-273.
      Strain: C57BL/6J.
      Tissue: Tongue.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-273.
      Tissue: Brain.
    4. "Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia."
      Moffatt P., Smith C.E., St Arnaud R., Nanci A.
      J. Cell. Biochem. 103:941-956(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiODAM_MOUSE
    AccessioniPrimary (citable) accession number: A1E960
    Secondary accession number(s): Q9D7E6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3