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A1E960

- ODAM_MOUSE

UniProt

A1E960 - ODAM_MOUSE

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Protein
Odontogenic ameloblast-associated protein
Gene
Odam, Apin
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process By similarity.

GO - Biological processi

  1. biomineral tissue development Source: UniProtKB-KW
  2. odontogenesis of dentin-containing tooth Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Biomineralization

Enzyme and pathway databases

ReactomeiREACT_198563. Amyloids.

Names & Taxonomyi

Protein namesi
Recommended name:
Odontogenic ameloblast-associated protein
Alternative name(s):
Apin
Gene namesi
Name:Odam
Synonyms:Apin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1916842. Odam.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular region Source: MGI
  3. fibril Source: Ensembl
  4. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed prediction
Add
BLAST
Chaini16 – 273258Odontogenic ameloblast-associated protein
PRO_5000183880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi114 – 1141O-linked (GalNAc...) Reviewed prediction
Glycosylationi118 – 1181O-linked (GalNAc...) Reviewed prediction
Glycosylationi159 – 1591O-linked (GalNAc...) Reviewed prediction
Glycosylationi240 – 2401O-linked (GalNAc...) Reviewed prediction
Glycosylationi241 – 2411O-linked (GalNAc...) Reviewed prediction
Glycosylationi247 – 2471O-linked (GalNAc...) Reviewed prediction
Glycosylationi252 – 2521O-linked (GalNAc...) Reviewed prediction
Glycosylationi258 – 2581O-linked (GalNAc...) Reviewed prediction
Glycosylationi267 – 2671O-linked (GalNAc...) Reviewed prediction

Post-translational modificationi

O-glycosylated By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA1E960.

Expressioni

Tissue specificityi

Highly expressed in tooth-associated epithelia. Predominantly expressed in mandible.1 Publication

Gene expression databases

BgeeiA1E960.
CleanExiMM_ODAM.
GenevestigatoriA1E960.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108899.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi62 – 196135Gln-rich
Add
BLAST

Sequence similaritiesi

Belongs to the ODAM family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG74202.
GeneTreeiENSGT00390000011100.
HOGENOMiHOG000115257.
HOVERGENiHBG096669.
InParanoidiA1E960.
OMAiNSWIPPF.
OrthoDBiEOG7673CG.
PhylomeDBiA1E960.
TreeFamiTF338424.

Family and domain databases

InterProiIPR026802. Odam.
[Graphical view]
PANTHERiPTHR16237. PTHR16237. 1 hit.
PfamiPF15424. ODAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1E960-1 [UniParc]FASTAAdd to Basket

« Hide

MKIIILLGLI GASSSAPLIS QRLLSASNSH ELLLNLNNGQ LLPLQFQGAF    50
NSWIPPFPGF LQQQQAQVSG RPQFTLSTLE SFAGLFPNQI PLSRQVGLAQ 100
GGQAGQPDLS QQQTPPQTQQ SASPMSYVVP VKVPQDQTQM FQYYPVYMLL 150
PWEQPQTVTS SPQHTGQQLF EEQIPFYNQF GFAPPQAEPG VPGGQQHLAF 200
DSFVGTAPET PGMPVEGSLL YPQKEPISFK HDNAGVFMPT TSPKPSTDNF 250
FTSGIDPTIA PEQKVKTDSL REP 273
Length:273
Mass (Da):29,820
Last modified:January 23, 2007 - v1
Checksum:iCA8B395AE68985B6
GO

Sequence cautioni

The sequence AAI32395.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAI32397.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB26200.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF113909 mRNA. Translation: ABL11578.1.
AK009298 mRNA. Translation: BAB26200.1. Different initiation.
BC132394 mRNA. Translation: AAI32395.1. Different initiation.
BC132396 mRNA. Translation: AAI32397.1. Different initiation.
CCDSiCCDS19394.2.
RefSeqiNP_081404.2. NM_027128.2.
XP_006535273.1. XM_006535210.1.
UniGeneiMm.389652.

Genome annotation databases

EnsembliENSMUST00000113274; ENSMUSP00000108899; ENSMUSG00000009580.
ENSMUST00000129757; ENSMUSP00000117898; ENSMUSG00000009580.
GeneIDi69592.
KEGGimmu:69592.
UCSCiuc008xzd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF113909 mRNA. Translation: ABL11578.1 .
AK009298 mRNA. Translation: BAB26200.1 . Different initiation.
BC132394 mRNA. Translation: AAI32395.1 . Different initiation.
BC132396 mRNA. Translation: AAI32397.1 . Different initiation.
CCDSi CCDS19394.2.
RefSeqi NP_081404.2. NM_027128.2.
XP_006535273.1. XM_006535210.1.
UniGenei Mm.389652.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000108899.

Proteomic databases

PRIDEi A1E960.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000113274 ; ENSMUSP00000108899 ; ENSMUSG00000009580 .
ENSMUST00000129757 ; ENSMUSP00000117898 ; ENSMUSG00000009580 .
GeneIDi 69592.
KEGGi mmu:69592.
UCSCi uc008xzd.1. mouse.

Organism-specific databases

CTDi 54959.
MGIi MGI:1916842. Odam.

Phylogenomic databases

eggNOGi NOG74202.
GeneTreei ENSGT00390000011100.
HOGENOMi HOG000115257.
HOVERGENi HBG096669.
InParanoidi A1E960.
OMAi NSWIPPF.
OrthoDBi EOG7673CG.
PhylomeDBi A1E960.
TreeFami TF338424.

Enzyme and pathway databases

Reactomei REACT_198563. Amyloids.

Miscellaneous databases

NextBioi 329866.
PROi A1E960.
SOURCEi Search...

Gene expression databases

Bgeei A1E960.
CleanExi MM_ODAM.
Genevestigatori A1E960.

Family and domain databases

InterProi IPR026802. Odam.
[Graphical view ]
PANTHERi PTHR16237. PTHR16237. 1 hit.
Pfami PF15424. ODAM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Moffatt P., Smith C.E., Nanci A.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
    Tissue: Mandible.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-273.
    Strain: C57BL/6J.
    Tissue: Tongue.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-273.
    Tissue: Brain.
  4. "Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia."
    Moffatt P., Smith C.E., St Arnaud R., Nanci A.
    J. Cell. Biochem. 103:941-956(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiODAM_MOUSE
AccessioniPrimary (citable) accession number: A1E960
Secondary accession number(s): Q9D7E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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