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Protein

Odontogenic ameloblast-associated protein

Gene

Odam

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization

Names & Taxonomyi

Protein namesi
Recommended name:
Odontogenic ameloblast-associated protein
Alternative name(s):
Apin
Gene namesi
Name:Odam
Synonyms:Apin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1916842. Odam.

Subcellular locationi

  • Secreted By similarity
  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

  • cell periphery Source: MGI
  • cytoplasm Source: MGI
  • extracellular region Source: MGI
  • extracellular space Source: MGI
  • fibril Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_500018388016 – 273Odontogenic ameloblast-associated proteinAdd BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi114O-linked (GalNAc...)Sequence analysis1
Glycosylationi118O-linked (GalNAc...)Sequence analysis1
Glycosylationi159O-linked (GalNAc...)Sequence analysis1
Glycosylationi240O-linked (GalNAc...)Sequence analysis1
Glycosylationi241O-linked (GalNAc...)Sequence analysis1
Glycosylationi247O-linked (GalNAc...)Sequence analysis1
Glycosylationi252O-linked (GalNAc...)Sequence analysis1
Glycosylationi258O-linked (GalNAc...)Sequence analysis1
Glycosylationi267O-linked (GalNAc...)Sequence analysis1

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA1E960.
PRIDEiA1E960.

PTM databases

PhosphoSitePlusiA1E960.

Expressioni

Tissue specificityi

Highly expressed in tooth-associated epithelia. Predominantly expressed in mandible.1 Publication

Gene expression databases

BgeeiENSMUSG00000009580.
CleanExiMM_ODAM.
GenevisibleiA1E960. MM.

Interactioni

Subunit structurei

Interacts (via C-terminus) with ARHGEF5.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108899.

Structurei

3D structure databases

ProteinModelPortaliA1E960.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 127Interaction with ARHGEF5By similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 196Gln-richAdd BLAST135

Sequence similaritiesi

Belongs to the ODAM family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IV9J. Eukaryota.
ENOG411182C. LUCA.
GeneTreeiENSGT00390000011100.
HOGENOMiHOG000115257.
HOVERGENiHBG096669.
InParanoidiA1E960.
OMAiNSWIPPF.
OrthoDBiEOG091G0RVL.
PhylomeDBiA1E960.
TreeFamiTF338424.

Family and domain databases

InterProiIPR026802. Odam.
[Graphical view]
PANTHERiPTHR16237. PTHR16237. 1 hit.
PfamiPF15424. ODAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1E960-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIIILLGLI GASSSAPLIS QRLLSASNSH ELLLNLNNGQ LLPLQFQGAF
60 70 80 90 100
NSWIPPFPGF LQQQQAQVSG RPQFTLSTLE SFAGLFPNQI PLSRQVGLAQ
110 120 130 140 150
GGQAGQPDLS QQQTPPQTQQ SASPMSYVVP VKVPQDQTQM FQYYPVYMLL
160 170 180 190 200
PWEQPQTVTS SPQHTGQQLF EEQIPFYNQF GFAPPQAEPG VPGGQQHLAF
210 220 230 240 250
DSFVGTAPET PGMPVEGSLL YPQKEPISFK HDNAGVFMPT TSPKPSTDNF
260 270
FTSGIDPTIA PEQKVKTDSL REP
Length:273
Mass (Da):29,820
Last modified:January 23, 2007 - v1
Checksum:iCA8B395AE68985B6
GO

Sequence cautioni

The sequence AAI32395 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI32397 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB26200 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF113909 mRNA. Translation: ABL11578.1.
AK009298 mRNA. Translation: BAB26200.1. Different initiation.
BC132394 mRNA. Translation: AAI32395.1. Different initiation.
BC132396 mRNA. Translation: AAI32397.1. Different initiation.
CCDSiCCDS19394.2.
RefSeqiNP_081404.2. NM_027128.2.
XP_006535273.1. XM_006535210.3.
UniGeneiMm.389652.

Genome annotation databases

EnsembliENSMUST00000113274; ENSMUSP00000108899; ENSMUSG00000009580.
ENSMUST00000129757; ENSMUSP00000117898; ENSMUSG00000009580.
GeneIDi69592.
KEGGimmu:69592.
UCSCiuc008xzd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF113909 mRNA. Translation: ABL11578.1.
AK009298 mRNA. Translation: BAB26200.1. Different initiation.
BC132394 mRNA. Translation: AAI32395.1. Different initiation.
BC132396 mRNA. Translation: AAI32397.1. Different initiation.
CCDSiCCDS19394.2.
RefSeqiNP_081404.2. NM_027128.2.
XP_006535273.1. XM_006535210.3.
UniGeneiMm.389652.

3D structure databases

ProteinModelPortaliA1E960.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108899.

PTM databases

PhosphoSitePlusiA1E960.

Proteomic databases

PaxDbiA1E960.
PRIDEiA1E960.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113274; ENSMUSP00000108899; ENSMUSG00000009580.
ENSMUST00000129757; ENSMUSP00000117898; ENSMUSG00000009580.
GeneIDi69592.
KEGGimmu:69592.
UCSCiuc008xzd.1. mouse.

Organism-specific databases

CTDi54959.
MGIiMGI:1916842. Odam.

Phylogenomic databases

eggNOGiENOG410IV9J. Eukaryota.
ENOG411182C. LUCA.
GeneTreeiENSGT00390000011100.
HOGENOMiHOG000115257.
HOVERGENiHBG096669.
InParanoidiA1E960.
OMAiNSWIPPF.
OrthoDBiEOG091G0RVL.
PhylomeDBiA1E960.
TreeFamiTF338424.

Miscellaneous databases

PROiA1E960.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009580.
CleanExiMM_ODAM.
GenevisibleiA1E960. MM.

Family and domain databases

InterProiIPR026802. Odam.
[Graphical view]
PANTHERiPTHR16237. PTHR16237. 1 hit.
PfamiPF15424. ODAM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiODAM_MOUSE
AccessioniPrimary (citable) accession number: A1E960
Secondary accession number(s): Q9D7E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.