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Protein

Odontogenic ameloblast-associated protein

Gene

ODAM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.1 Publication

GO - Biological processi

  • biomineral tissue development Source: UniProtKB-KW
  • cellular protein metabolic process Source: Reactome
  • inflammatory response Source: UniProtKB
  • odontogenesis of dentin-containing tooth Source: HGNC
  • positive regulation of epithelial cell proliferation involved in wound healing Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
  • regulation of actin cytoskeleton organization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Biomineralization

Enzyme and pathway databases

ReactomeiR-HSA-977225. Amyloid fiber formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Odontogenic ameloblast-associated protein
Alternative name(s):
Apin
Gene namesi
Name:ODAM
Synonyms:APIN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26043. ODAM.

Subcellular locationi

  • Secreted By similarity
  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

  • cell periphery Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • fibril Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi54959.
OpenTargetsiENSG00000109205.
PharmGKBiPA145148342.

Polymorphism and mutation databases

BioMutaiODAM.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_500018387916 – 279Odontogenic ameloblast-associated proteinAdd BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115O-linked (GalNAc...)Sequence analysis1
Glycosylationi119O-linked (GalNAc...)Sequence analysis1
Glycosylationi244O-linked (GalNAc...)Sequence analysis1
Glycosylationi249O-linked (GalNAc...)Sequence analysis1
Glycosylationi250O-linked (GalNAc...)Sequence analysis1
Glycosylationi251O-linked (GalNAc...)Sequence analysis1
Glycosylationi255O-linked (GalNAc...)Sequence analysis1
Glycosylationi256O-linked (GalNAc...)Sequence analysis1
Glycosylationi261O-linked (GalNAc...)Sequence analysis1
Glycosylationi263O-linked (GalNAc...)Sequence analysis1
Glycosylationi273O-linked (GalNAc...)Sequence analysis1
Glycosylationi275O-linked (GalNAc...)Sequence analysis1

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA1E959.
PRIDEiA1E959.

PTM databases

iPTMnetiA1E959.
PhosphoSitePlusiA1E959.

Expressioni

Tissue specificityi

Expressed in the junctional epithelium of healthy teeth. In periodontitis, absent in the pocket epithelium of the diseased periodontium but is detected in the gingival crevicular fluid.1 Publication

Gene expression databases

BgeeiENSG00000109205.
CleanExiHS_ODAM.
ExpressionAtlasiA1E959. baseline and differential.
GenevisibleiA1E959. HS.

Organism-specific databases

HPAiHPA036543.

Interactioni

Subunit structurei

Interacts (via C-terminus) with ARHGEF5.1 Publication

Protein-protein interaction databases

BioGridi120297. 5 interactors.
IntActiA1E959. 3 interactors.
STRINGi9606.ENSP00000379401.

Structurei

3D structure databases

ProteinModelPortaliA1E959.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 129Interaction with ARHGEF51 Publication3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 206Gln-richAdd BLAST145

Sequence similaritiesi

Belongs to the ODAM family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IV9J. Eukaryota.
ENOG411182C. LUCA.
GeneTreeiENSGT00390000011100.
HOGENOMiHOG000115257.
HOVERGENiHBG096669.
InParanoidiA1E959.
OMAiNSWIPPF.
OrthoDBiEOG091G0RVL.
PhylomeDBiA1E959.
TreeFamiTF338424.

Family and domain databases

InterProiIPR026802. Odam.
[Graphical view]
PANTHERiPTHR16237. PTHR16237. 1 hit.
PfamiPF15424. ODAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1E959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIIILLGFL GATLSAPLIP QRLMSASNSN ELLLNLNNGQ LLPLQLQGPL
60 70 80 90 100
NSWIPPFSGI LQQQQQAQIP GLSQFSLSAL DQFAGLLPNQ IPLTGEASFA
110 120 130 140 150
QGAQAGQVDP LQLQTPPQTQ PGPSHVMPYV FSFKMPQEQG QMFQYYPVYM
160 170 180 190 200
VLPWEQPQQT VPRSPQQTRQ QQYEEQIPFY AQFGYIPQLA EPAISGGQQQ
210 220 230 240 250
LAFDPQLGTA PEIAVMSTGE EIPYLQKEAI NFRHDSAGVF MPSTSPKPST
260 270
TNVFTSAVDQ TITPELPEEK DKTDSLREP
Length:279
Mass (Da):30,777
Last modified:January 23, 2007 - v1
Checksum:iDE0E42076B572318
GO

Sequence cautioni

The sequence BAA91226 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039812222I → T.1 PublicationCorresponds to variant rs3196714dbSNPEnsembl.1
Natural variantiVAR_039813269E → D in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF113908 mRNA. Translation: ABL11577.1.
CH471057 Genomic DNA. Translation: EAX05612.1.
AK000520 mRNA. Translation: BAA91226.1. Different initiation.
BC017796 mRNA. Translation: AAH17796.1.
CCDSiCCDS3536.2.
RefSeqiNP_060325.3. NM_017855.3.
UniGeneiHs.143811.

Genome annotation databases

EnsembliENST00000396094; ENSP00000379401; ENSG00000109205.
GeneIDi54959.
KEGGihsa:54959.
UCSCiuc003hfc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF113908 mRNA. Translation: ABL11577.1.
CH471057 Genomic DNA. Translation: EAX05612.1.
AK000520 mRNA. Translation: BAA91226.1. Different initiation.
BC017796 mRNA. Translation: AAH17796.1.
CCDSiCCDS3536.2.
RefSeqiNP_060325.3. NM_017855.3.
UniGeneiHs.143811.

3D structure databases

ProteinModelPortaliA1E959.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120297. 5 interactors.
IntActiA1E959. 3 interactors.
STRINGi9606.ENSP00000379401.

PTM databases

iPTMnetiA1E959.
PhosphoSitePlusiA1E959.

Polymorphism and mutation databases

BioMutaiODAM.

Proteomic databases

PaxDbiA1E959.
PRIDEiA1E959.

Protocols and materials databases

DNASUi54959.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396094; ENSP00000379401; ENSG00000109205.
GeneIDi54959.
KEGGihsa:54959.
UCSCiuc003hfc.4. human.

Organism-specific databases

CTDi54959.
DisGeNETi54959.
GeneCardsiODAM.
HGNCiHGNC:26043. ODAM.
HPAiHPA036543.
MIMi614843. gene.
neXtProtiNX_A1E959.
OpenTargetsiENSG00000109205.
PharmGKBiPA145148342.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IV9J. Eukaryota.
ENOG411182C. LUCA.
GeneTreeiENSGT00390000011100.
HOGENOMiHOG000115257.
HOVERGENiHBG096669.
InParanoidiA1E959.
OMAiNSWIPPF.
OrthoDBiEOG091G0RVL.
PhylomeDBiA1E959.
TreeFamiTF338424.

Enzyme and pathway databases

ReactomeiR-HSA-977225. Amyloid fiber formation.

Miscellaneous databases

GeneWikiiODAM_(gene).
GenomeRNAii54959.
PROiA1E959.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109205.
CleanExiHS_ODAM.
ExpressionAtlasiA1E959. baseline and differential.
GenevisibleiA1E959. HS.

Family and domain databases

InterProiIPR026802. Odam.
[Graphical view]
PANTHERiPTHR16237. PTHR16237. 1 hit.
PfamiPF15424. ODAM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiODAM_HUMAN
AccessioniPrimary (citable) accession number: A1E959
Secondary accession number(s): Q8WWE5, Q9NWZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

ODAM protein is the unique constituent of calcifying epithelial odontogenic tumors (CEOTs), also known as Pindborg tumors. CEOTs are benign but locally aggressive pathologic entities arising mainly in the mandible and commonly associated with an unerupted or embedded tooth. They are characterized by the presence of squamous-cell proliferation, calcification, and, notably, amyloid deposits.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.