A1E959 (ODAM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Odontogenic ameloblast-associated protein

Alternative name(s):
Apin

Gene names

Name:	ODAM
Synonyms:	APIN

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process.
Subcellular location	Secreted By similarity.
Post-translational modification	O-glycosylated By similarity.
Miscellaneous	ODAM protein is the unique constituent of calcifying epithelial odontogenic tumors (CEOTs), also known as Pindborg tumors. CEOTs are benign but locally aggressive pathologic entities arising mainly in the mandible and commonly associated with an unerupted or embedded tooth. They are characterized by the presence of squamous-cell proliferation, calcification, and, notably, amyloid deposits.
Sequence similarities	Belongs to the ODAM family.
Sequence caution	The sequence BAA91226.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Biomineralization
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	biomineral tissue development Inferred from electronic annotation. Source: UniProtKB-KW odontogenesis of dentin-containing tooth Inferred from expression pattern. Source: HGNC
Cellular component	fibril Inferred from direct assay Ref.5. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 279	264	Odontogenic ameloblast-associated protein		PRO_5000183879
Regions
	Compositional bias	62 – 206	145	Gln-rich
Amino acid modifications
	Glycosylation	115	1	O-linked (GalNAc...) Potential
	Glycosylation	119	1	O-linked (GalNAc...) Potential
	Glycosylation	244	1	O-linked (GalNAc...) Potential
	Glycosylation	249	1	O-linked (GalNAc...) Potential
	Glycosylation	250	1	O-linked (GalNAc...) Potential
	Glycosylation	251	1	O-linked (GalNAc...) Potential
	Glycosylation	255	1	O-linked (GalNAc...) Potential
	Glycosylation	256	1	O-linked (GalNAc...) Potential
	Glycosylation	261	1	O-linked (GalNAc...) Potential
	Glycosylation	263	1	O-linked (GalNAc...) Potential
	Glycosylation	273	1	O-linked (GalNAc...) Potential
	Glycosylation	275	1	O-linked (GalNAc...) Potential
Natural variations
	Natural variant	222	1	I → T. Ref.3 Corresponds to variant rs3196714 [ dbSNP | Ensembl ].		VAR_039812
	Natural variant	269	1	E → D in a colorectal cancer sample; somatic mutation. Ref.7		VAR_039813

Sequences

	Sequence		Length	Mass (Da)
	A1E959 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: DE0E42076B572318	FASTA	279	30,777
	10 20 30 40 50 60 MKIIILLGFL GATLSAPLIP QRLMSASNSN ELLLNLNNGQ LLPLQLQGPL NSWIPPFSGI 70 80 90 100 110 120 LQQQQQAQIP GLSQFSLSAL DQFAGLLPNQ IPLTGEASFA QGAQAGQVDP LQLQTPPQTQ 130 140 150 160 170 180 PGPSHVMPYV FSFKMPQEQG QMFQYYPVYM VLPWEQPQQT VPRSPQQTRQ QQYEEQIPFY 190 200 210 220 230 240 AQFGYIPQLA EPAISGGQQQ LAFDPQLGTA PEIAVMSTGE EIPYLQKEAI NFRHDSAGVF 250 260 270 MPSTSPKPST TNVFTSAVDQ TITPELPEEK DKTDSLREP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Moffatt P., Smith C.E., Nanci A. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-279, VARIANT THR-222. Tissue: Carcinoma.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-279. Tissue: Lung.
[5]	"Calcifying epithelial odontogenic (Pindborg) tumor-associated amyloid consists of a novel human protein." Solomon A., Murphy C.L., Weaver K., Weiss D.T., Hrncic R., Eulitz M., Donnell R.L., Sletten K., Westermark G., Westermark P. J. Lab. Clin. Med. 142:348-355(2003) [PubMed: 14647039] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INVOLVEMENT IN CEOT.
[6]	"Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia." Moffatt P., Smith C.E., St Arnaud R., Nanci A. J. Cell. Biochem. 103:941-956(2008) [PubMed: 17647262] [Abstract] Cited for: IDENTIFICATION.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-269.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF113908 mRNA. Translation: ABL11577.1. CH471057 Genomic DNA. Translation: EAX05612.1. AK000520 mRNA. Translation: BAA91226.1. Different initiation. BC017796 mRNA. Translation: AAH17796.1.
IPI	IPI00152784.
RefSeq	NP_060325.3. NM_017855.3.
UniGene	Hs.143811.
3D structure databases
ProteinModelPortal	A1E959.
ModBase	Search...
Protein-protein interaction databases
STRING	A1E959.
Proteomic databases
PRIDE	A1E959.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000396094; ENSP00000379401; ENSG00000109205.
GeneID	54959.
KEGG	hsa:54959.
UCSC	uc003hfc.1. human.
Organism-specific databases
CTD	54959.
GeneCards	GC04P071098.
H-InvDB	HIX0004261.
HGNC	HGNC:26043. ODAM.
HPA	HPA036543.
neXtProt	NX_A1E959.
PharmGKB	PA145148342.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG17157.
GeneTree	ENSGT00390000011100.
HOGENOM	HBG283177.
HOVERGEN	HBG096669.
InParanoid	A1E959.
OMA	NSWIPPF.
OrthoDB	EOG4H19WZ.
Enzyme and pathway databases
Reactome	REACT_75925. Amyloids.
Gene expression databases
Bgee	A1E959.
CleanEx	HS_ODAM.
Genevestigator	A1E959.
Family and domain databases
ProtoNet	Search...
Other
NextBio	58156.

Entry information

Entry name

ODAM_HUMAN

Accession

Primary (citable) accession number: A1E959
Secondary accession number(s): Q8WWE5, Q9NWZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.