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A1E959 (ODAM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Odontogenic ameloblast-associated protein
Alternative name(s):
Apin
Gene names
Name:ODAM
Synonyms:APIN
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process.

Subcellular location

Secreted By similarity.

Post-translational modification

O-glycosylated By similarity.

Miscellaneous

ODAM protein is the unique constituent of calcifying epithelial odontogenic tumors (CEOTs), also known as Pindborg tumors. CEOTs are benign but locally aggressive pathologic entities arising mainly in the mandible and commonly associated with an unerupted or embedded tooth. They are characterized by the presence of squamous-cell proliferation, calcification, and, notably, amyloid deposits.

Sequence similarities

Belongs to the ODAM family.

Sequence caution

The sequence BAA91226.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processBiomineralization
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbiomineral tissue development

Inferred from electronic annotation. Source: UniProtKB-KW

odontogenesis of dentin-containing tooth

Inferred from expression pattern PubMed 16674676. Source: HGNC

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular region

Traceable author statement. Source: Reactome

fibril

Inferred from direct assay Ref.5. Source: UniProtKB

nucleus

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 279264Odontogenic ameloblast-associated protein
PRO_5000183879

Regions

Compositional bias62 – 206145Gln-rich

Amino acid modifications

Glycosylation1151O-linked (GalNAc...) Potential
Glycosylation1191O-linked (GalNAc...) Potential
Glycosylation2441O-linked (GalNAc...) Potential
Glycosylation2491O-linked (GalNAc...) Potential
Glycosylation2501O-linked (GalNAc...) Potential
Glycosylation2511O-linked (GalNAc...) Potential
Glycosylation2551O-linked (GalNAc...) Potential
Glycosylation2561O-linked (GalNAc...) Potential
Glycosylation2611O-linked (GalNAc...) Potential
Glycosylation2631O-linked (GalNAc...) Potential
Glycosylation2731O-linked (GalNAc...) Potential
Glycosylation2751O-linked (GalNAc...) Potential

Natural variations

Natural variant2221I → T. Ref.3
Corresponds to variant rs3196714 [ dbSNP | Ensembl ].
VAR_039812
Natural variant2691E → D in a colorectal cancer sample; somatic mutation. Ref.7
VAR_039813

Sequences

Sequence LengthMass (Da)Tools
A1E959 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: DE0E42076B572318

FASTA27930,777
        10         20         30         40         50         60 
MKIIILLGFL GATLSAPLIP QRLMSASNSN ELLLNLNNGQ LLPLQLQGPL NSWIPPFSGI 

        70         80         90        100        110        120 
LQQQQQAQIP GLSQFSLSAL DQFAGLLPNQ IPLTGEASFA QGAQAGQVDP LQLQTPPQTQ 

       130        140        150        160        170        180 
PGPSHVMPYV FSFKMPQEQG QMFQYYPVYM VLPWEQPQQT VPRSPQQTRQ QQYEEQIPFY 

       190        200        210        220        230        240 
AQFGYIPQLA EPAISGGQQQ LAFDPQLGTA PEIAVMSTGE EIPYLQKEAI NFRHDSAGVF 

       250        260        270 
MPSTSPKPST TNVFTSAVDQ TITPELPEEK DKTDSLREP 

« Hide

References

« Hide 'large scale' references
[1]Moffatt P., Smith C.E., Nanci A.
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-279, VARIANT THR-222.
Tissue: Carcinoma.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-279.
Tissue: Lung.
[5]"Calcifying epithelial odontogenic (Pindborg) tumor-associated amyloid consists of a novel human protein."
Solomon A., Murphy C.L., Weaver K., Weiss D.T., Hrncic R., Eulitz M., Donnell R.L., Sletten K., Westermark G., Westermark P.
J. Lab. Clin. Med. 142:348-355(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INVOLVEMENT IN CEOT.
[6]"Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia."
Moffatt P., Smith C.E., St Arnaud R., Nanci A.
J. Cell. Biochem. 103:941-956(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-269.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF113908 mRNA. Translation: ABL11577.1.
CH471057 Genomic DNA. Translation: EAX05612.1.
AK000520 mRNA. Translation: BAA91226.1. Different initiation.
BC017796 mRNA. Translation: AAH17796.1.
RefSeqNP_060325.3. NM_017855.3.
UniGeneHs.143811.

3D structure databases

ProteinModelPortalA1E959.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120297. 2 interactions.
IntActA1E959. 2 interactions.
STRING9606.ENSP00000379401.

Proteomic databases

PRIDEA1E959.

Protocols and materials databases

DNASU54959.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000396094; ENSP00000379401; ENSG00000109205.
GeneID54959.
KEGGhsa:54959.
UCSCuc003hfc.3. human.

Organism-specific databases

CTD54959.
GeneCardsGC04P071062.
HGNCHGNC:26043. ODAM.
MIM614843. gene.
neXtProtNX_A1E959.
PharmGKBPA145148342.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG74202.
HOGENOMHOG000115257.
HOVERGENHBG096669.
InParanoidA1E959.
OMANSWIPPF.
OrthoDBEOG7673CG.
PhylomeDBA1E959.
TreeFamTF338424.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.

Gene expression databases

ArrayExpressA1E959.
BgeeA1E959.
CleanExHS_ODAM.
GenevestigatorA1E959.

Family and domain databases

InterProIPR026802. Odam.
[Graphical view]
PANTHERPTHR16237. PTHR16237. 1 hit.
PfamPF15424. ODAM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiODAM_(gene).
GenomeRNAi54959.
NextBio58156.
PROA1E959.
SOURCESearch...

Entry information

Entry nameODAM_HUMAN
AccessionPrimary (citable) accession number: A1E959
Secondary accession number(s): Q8WWE5, Q9NWZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM