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A1E959

- ODAM_HUMAN

UniProt

A1E959 - ODAM_HUMAN

Protein

Odontogenic ameloblast-associated protein

Gene

ODAM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process.

    GO - Biological processi

    1. biomineral tissue development Source: UniProtKB-KW
    2. odontogenesis of dentin-containing tooth Source: HGNC

    Keywords - Biological processi

    Biomineralization

    Enzyme and pathway databases

    ReactomeiREACT_75925. Amyloids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Odontogenic ameloblast-associated protein
    Alternative name(s):
    Apin
    Gene namesi
    Name:ODAM
    Synonyms:APIN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:26043. ODAM.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular region Source: Reactome
    3. fibril Source: UniProtKB
    4. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145148342.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 279264Odontogenic ameloblast-associated proteinPRO_5000183879Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi115 – 1151O-linked (GalNAc...)Sequence Analysis
    Glycosylationi119 – 1191O-linked (GalNAc...)Sequence Analysis
    Glycosylationi244 – 2441O-linked (GalNAc...)Sequence Analysis
    Glycosylationi249 – 2491O-linked (GalNAc...)Sequence Analysis
    Glycosylationi250 – 2501O-linked (GalNAc...)Sequence Analysis
    Glycosylationi251 – 2511O-linked (GalNAc...)Sequence Analysis
    Glycosylationi255 – 2551O-linked (GalNAc...)Sequence Analysis
    Glycosylationi256 – 2561O-linked (GalNAc...)Sequence Analysis
    Glycosylationi261 – 2611O-linked (GalNAc...)Sequence Analysis
    Glycosylationi263 – 2631O-linked (GalNAc...)Sequence Analysis
    Glycosylationi273 – 2731O-linked (GalNAc...)Sequence Analysis
    Glycosylationi275 – 2751O-linked (GalNAc...)Sequence Analysis

    Post-translational modificationi

    O-glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiA1E959.

    Expressioni

    Gene expression databases

    ArrayExpressiA1E959.
    BgeeiA1E959.
    CleanExiHS_ODAM.
    GenevestigatoriA1E959.

    Interactioni

    Protein-protein interaction databases

    BioGridi120297. 2 interactions.
    IntActiA1E959. 2 interactions.
    STRINGi9606.ENSP00000379401.

    Structurei

    3D structure databases

    ProteinModelPortaliA1E959.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi62 – 206145Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ODAM family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG74202.
    HOGENOMiHOG000115257.
    HOVERGENiHBG096669.
    InParanoidiA1E959.
    OMAiNSWIPPF.
    OrthoDBiEOG7673CG.
    PhylomeDBiA1E959.
    TreeFamiTF338424.

    Family and domain databases

    InterProiIPR026802. Odam.
    [Graphical view]
    PANTHERiPTHR16237. PTHR16237. 1 hit.
    PfamiPF15424. ODAM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1E959-1 [UniParc]FASTAAdd to Basket

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    MKIIILLGFL GATLSAPLIP QRLMSASNSN ELLLNLNNGQ LLPLQLQGPL    50
    NSWIPPFSGI LQQQQQAQIP GLSQFSLSAL DQFAGLLPNQ IPLTGEASFA 100
    QGAQAGQVDP LQLQTPPQTQ PGPSHVMPYV FSFKMPQEQG QMFQYYPVYM 150
    VLPWEQPQQT VPRSPQQTRQ QQYEEQIPFY AQFGYIPQLA EPAISGGQQQ 200
    LAFDPQLGTA PEIAVMSTGE EIPYLQKEAI NFRHDSAGVF MPSTSPKPST 250
    TNVFTSAVDQ TITPELPEEK DKTDSLREP 279
    Length:279
    Mass (Da):30,777
    Last modified:January 23, 2007 - v1
    Checksum:iDE0E42076B572318
    GO

    Sequence cautioni

    The sequence BAA91226.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti222 – 2221I → T.1 Publication
    Corresponds to variant rs3196714 [ dbSNP | Ensembl ].
    VAR_039812
    Natural varianti269 – 2691E → D in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_039813

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF113908 mRNA. Translation: ABL11577.1.
    CH471057 Genomic DNA. Translation: EAX05612.1.
    AK000520 mRNA. Translation: BAA91226.1. Different initiation.
    BC017796 mRNA. Translation: AAH17796.1.
    CCDSiCCDS3536.2.
    RefSeqiNP_060325.3. NM_017855.3.
    UniGeneiHs.143811.

    Genome annotation databases

    EnsembliENST00000396094; ENSP00000379401; ENSG00000109205.
    GeneIDi54959.
    KEGGihsa:54959.
    UCSCiuc003hfc.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF113908 mRNA. Translation: ABL11577.1 .
    CH471057 Genomic DNA. Translation: EAX05612.1 .
    AK000520 mRNA. Translation: BAA91226.1 . Different initiation.
    BC017796 mRNA. Translation: AAH17796.1 .
    CCDSi CCDS3536.2.
    RefSeqi NP_060325.3. NM_017855.3.
    UniGenei Hs.143811.

    3D structure databases

    ProteinModelPortali A1E959.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120297. 2 interactions.
    IntActi A1E959. 2 interactions.
    STRINGi 9606.ENSP00000379401.

    Proteomic databases

    PRIDEi A1E959.

    Protocols and materials databases

    DNASUi 54959.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000396094 ; ENSP00000379401 ; ENSG00000109205 .
    GeneIDi 54959.
    KEGGi hsa:54959.
    UCSCi uc003hfc.3. human.

    Organism-specific databases

    CTDi 54959.
    GeneCardsi GC04P071062.
    HGNCi HGNC:26043. ODAM.
    MIMi 614843. gene.
    neXtProti NX_A1E959.
    PharmGKBi PA145148342.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74202.
    HOGENOMi HOG000115257.
    HOVERGENi HBG096669.
    InParanoidi A1E959.
    OMAi NSWIPPF.
    OrthoDBi EOG7673CG.
    PhylomeDBi A1E959.
    TreeFami TF338424.

    Enzyme and pathway databases

    Reactomei REACT_75925. Amyloids.

    Miscellaneous databases

    GeneWikii ODAM_(gene).
    GenomeRNAii 54959.
    NextBioi 58156.
    PROi A1E959.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A1E959.
    Bgeei A1E959.
    CleanExi HS_ODAM.
    Genevestigatori A1E959.

    Family and domain databases

    InterProi IPR026802. Odam.
    [Graphical view ]
    PANTHERi PTHR16237. PTHR16237. 1 hit.
    Pfami PF15424. ODAM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Moffatt P., Smith C.E., Nanci A.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-279, VARIANT THR-222.
      Tissue: Carcinoma.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 127-279.
      Tissue: Lung.
    5. "Calcifying epithelial odontogenic (Pindborg) tumor-associated amyloid consists of a novel human protein."
      Solomon A., Murphy C.L., Weaver K., Weiss D.T., Hrncic R., Eulitz M., Donnell R.L., Sletten K., Westermark G., Westermark P.
      J. Lab. Clin. Med. 142:348-355(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INVOLVEMENT IN CEOT.
    6. "Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia."
      Moffatt P., Smith C.E., St Arnaud R., Nanci A.
      J. Cell. Biochem. 103:941-956(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-269.

    Entry informationi

    Entry nameiODAM_HUMAN
    AccessioniPrimary (citable) accession number: A1E959
    Secondary accession number(s): Q8WWE5, Q9NWZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    ODAM protein is the unique constituent of calcifying epithelial odontogenic tumors (CEOTs), also known as Pindborg tumors. CEOTs are benign but locally aggressive pathologic entities arising mainly in the mandible and commonly associated with an unerupted or embedded tooth. They are characterized by the presence of squamous-cell proliferation, calcification, and, notably, amyloid deposits.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3