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Protein

Beta-lactamase

Gene

blaSCO-1

Organism
Escherichia coli
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processAntibiotic resistanceUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotationSAAS annotation (EC:3.5.2.6UniRule annotationSAAS annotation)
Gene namesi
Name:blaSCO-1Imported
Encoded oniPlasmid p3521Imported
Plasmid pR3521Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075073.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500763348426 – 288Beta-lactamaseSequence analysisAdd BLAST263

Interactioni

Chemistry databases

BindingDBiA1E3K9.

Structurei

3D structure databases

ProteinModelPortaliA1E3K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiView protein in InterPro
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiView protein in PROSITE
PS00146. BETA_LACTAMASE_A. 1 hit.

Sequencei

Sequence statusi: Complete.

A1E3K9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRSALLIPL TTAAIALNAI SPVYASDTHS IDDTVKQVET TLGAKVGIAV
60 70 80 90 100
LDTGSQRAWF HRADDRFPMA STSKALTCAA LLDKGQSFMN KEALIKKADL
110 120 130 140 150
DEYAPVTSGI VGKKVSAADL CSITMRTSDN TAVNKVLEIL GGPQAVTAYL
160 170 180 190 200
RKTGDNITRL DRNEPDLNEG TPGDVRDTTT PRAILETLNK LVLGPTLGSD
210 220 230 240 250
ERKQLTTWLE SNEVGDPLLR AGVPSDWRVA DRTGAGGNGT RGVIAVMWPP
260 270 280
KHAPIIAAIY ITQTKATMEE RNAAIASIGK AIAAEVLE
Length:288
Mass (Da):30,648
Last modified:January 23, 2007 - v1
Checksum:iC16742EF2C0FC56D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF104648 Genomic DNA. Translation: ABL14266.1.
GU256641 Genomic DNA. Translation: ADB84924.1.
RefSeqiWP_004197546.1. NC_014843.1.
YP_004119723.1. NC_014843.1.

Genome annotation databases

GeneIDi10076137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF104648 Genomic DNA. Translation: ABL14266.1.
GU256641 Genomic DNA. Translation: ADB84924.1.
RefSeqiWP_004197546.1. NC_014843.1.
YP_004119723.1. NC_014843.1.

3D structure databases

ProteinModelPortaliA1E3K9.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiA1E3K9.
ChEMBLiCHEMBL1075073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10076137.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiView protein in InterPro
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiView protein in PROSITE
PS00146. BETA_LACTAMASE_A. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA1E3K9_ECOLX
AccessioniPrimary (citable) accession number: A1E3K9
Entry historyiIntegrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

PlasmidImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.