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Protein

Ras-like protein family member 11A-like

Gene

zgc:110179

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regulator of rDNA transcription.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 50GTPBy similarity8
Nucleotide bindingi90 – 97GTPBy similarity8
Nucleotide bindingi157 – 160GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein family member 11A-like
Gene namesi
ORF Names:zgc:110179
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-050417-384. rasl11a.

Subcellular locationi

  • Nucleusnucleolus By similarity

  • Note: Associates with rDNA transcription unit throughout the cell cycle.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083631 – 253Ras-like protein family member 11A-likeAdd BLAST253

Proteomic databases

PaxDbiA1DZY4.
PRIDEiA1DZY4.

Expressioni

Gene expression databases

BgeeiENSDARG00000046013.
ExpressionAtlasiA1DZY4. differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000067646.

Structurei

3D structure databases

ProteinModelPortaliA1DZY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133696.
HOGENOMiHOG000233973.
HOVERGENiHBG108422.
InParanoidiA1DZY4.
KOiK07852.
OMAiYEANTGA.
OrthoDBiEOG091G0M6D.
TreeFamiTF318030.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1DZY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLIEQPRT MSSGSSNFLL VPIPEYPVLD CVPNKNVKIV VLGASNVGKT
60 70 80 90 100
ALIVRFLTKR FIGDYEANTG ALYSRKINLD GEQVSLQVQD TPCVSLQDDA
110 120 130 140 150
DGLYCQEQIN RSIYWADGYV LVFSITDLNS YRTIQPLYQH VRRIHPSGNI
160 170 180 190 200
PVIIVGNKSD LLRARQVSDP EGKALADELG GLYFEASARE NHESVQAAFL
210 220 230 240 250
HLCQEVSRAL GGGNGEKRKG GLHLARPKSP NMQELKRRFR QVLSSKVKSA

TAL
Length:253
Mass (Da):28,052
Last modified:January 23, 2007 - v1
Checksum:i04F31124694D6D67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF088669 mRNA. Translation: ABK96901.1.
CR381676 Genomic DNA. No translation available.
RefSeqiNP_001017840.2. NM_001017840.2.
UniGeneiDr.11735.

Genome annotation databases

EnsembliENSDART00000067647; ENSDARP00000067646; ENSDARG00000046013.
GeneIDi550538.
KEGGidre:550538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF088669 mRNA. Translation: ABK96901.1.
CR381676 Genomic DNA. No translation available.
RefSeqiNP_001017840.2. NM_001017840.2.
UniGeneiDr.11735.

3D structure databases

ProteinModelPortaliA1DZY4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000067646.

Proteomic databases

PaxDbiA1DZY4.
PRIDEiA1DZY4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000067647; ENSDARP00000067646; ENSDARG00000046013.
GeneIDi550538.
KEGGidre:550538.

Organism-specific databases

CTDi387496.
ZFINiZDB-GENE-050417-384. rasl11a.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133696.
HOGENOMiHOG000233973.
HOVERGENiHBG108422.
InParanoidiA1DZY4.
KOiK07852.
OMAiYEANTGA.
OrthoDBiEOG091G0M6D.
TreeFamiTF318030.

Miscellaneous databases

PROiA1DZY4.

Gene expression databases

BgeeiENSDARG00000046013.
ExpressionAtlasiA1DZY4. differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRSLBL_DANRE
AccessioniPrimary (citable) accession number: A1DZY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Although highly related to the Ras family, lacks the conserved prenylation motif at the C-terminus, which serves to target Ras proteins to membrane compartments.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.