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Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei266 – 2661PROSITE-ProRule annotation
Active sitei458 – 4581PROSITE-ProRule annotation
Active sitei520 – 5201PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: EnsemblFungi

GO - Biological processi

  1. phytochelatin biosynthetic process Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:cpyA
ORF Names:NFIA_059500
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_059500.

Subcellular locationi

  1. Vacuole By similarity

GO - Cellular componenti

  1. fungal-type vacuole Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 124107By similarityPRO_0000407457Add
BLAST
Chaini125 – 543419Carboxypeptidase Y homolog APRO_0000407458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi179 ↔ 419By similarity
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi313 ↔ 327By similarity
Disulfide bondi337 ↔ 360By similarity
Disulfide bondi344 ↔ 353By similarity
Disulfide bondi382 ↔ 389By similarity
Glycosylationi509 – 5091N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiA1DP75.

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00004297.

Structurei

3D structure databases

ProteinModelPortaliA1DP75.
SMRiA1DP75. Positions 124-540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000198296.
KOiK13289.
OMAiNTESSWI.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1DP75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLPATLLV GAATAAAPPF QQILGLPKKG ADTLAKPLHD LQEQLKTLSG
60 70 80 90 100
EARHLWDEVA NHFPNNMDHN PVFSLPKKHT RRPDSHWDHI VRGADVQSVW
110 120 130 140 150
VTGASGEKER EIDGKLEAYD LRVKKTDPSA LGIDPGVKQY TGYLDDNEND
160 170 180 190 200
KHLFYWFFES RNDPKNDPVV LWLNGGPGCS SLTGLFLELG PSSINEKIKP
210 220 230 240 250
IYNDFAWNSN ASVIFLDQPV NVGYSYSGAA VSDTVAAGKD VYALLTLFFK
260 270 280 290 300
QFPEYAKQDF HIAGESYAGH YIPVFASEIL SHKKRNINLK SVLIGNGLTD
310 320 330 340 350
GLTQYDYYRP MACGEGGYPA VLDEASCQSM DNALPRCKSM IESCYNTESS
360 370 380 390 400
WICVPASIYC NNALLGPYQR TGQNVYDIRG KCEDTSNLCY KGMGYVSEYL
410 420 430 440 450
NKREVREAVG AEVDGYESCN FDINRNFLFH GDWMKPYHRL VPGLLEQIPV
460 470 480 490 500
LIYAGDADFI CNWLGNKAWT EALEWPGQKE YAPLPLKDLV IEENEHKGKK
510 520 530 540
IGQIKSHGNF TFMRLYGAGH MVPMDQPEAS LEFFNRWLGG EWF
Length:543
Mass (Da):60,942
Last modified:January 23, 2007 - v1
Checksum:iF20A7038AC2F12DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027698 Genomic DNA. Translation: EAW16596.1.
RefSeqiXP_001258493.1. XM_001258492.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00004425; CADNFIAP00004297; CADNFIAG00004425.
GeneIDi4585009.
KEGGinfi:NFIA_059500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027698 Genomic DNA. Translation: EAW16596.1.
RefSeqiXP_001258493.1. XM_001258492.1.

3D structure databases

ProteinModelPortaliA1DP75.
SMRiA1DP75. Positions 124-540.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi36630.CADNFIAP00004297.

Protein family/group databases

MEROPSiS10.001.

Proteomic databases

PRIDEiA1DP75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADNFIAT00004425; CADNFIAP00004297; CADNFIAG00004425.
GeneIDi4585009.
KEGGinfi:NFIA_059500.

Organism-specific databases

EuPathDBiFungiDB:NFIA_059500.

Phylogenomic databases

eggNOGiCOG2939.
HOGENOMiHOG000198296.
KOiK13289.
OMAiNTESSWI.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
IPR008442. Propeptide_carboxypepY.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiCBPYA_NEOFI
AccessioniPrimary (citable) accession number: A1DP75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.