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A1DP75

- CBPYA_NEOFI

UniProt

A1DP75 - CBPYA_NEOFI

Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei266 – 2661PROSITE-ProRule annotation
    Active sitei458 – 4581PROSITE-ProRule annotation
    Active sitei520 – 5201PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:cpyA
    ORF Names:NFIA_059500
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 124107By similarityPRO_0000407457Add
    BLAST
    Chaini125 – 543419Carboxypeptidase Y homolog APRO_0000407458Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi179 ↔ 419By similarity
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi313 ↔ 327By similarity
    Disulfide bondi337 ↔ 360By similarity
    Disulfide bondi344 ↔ 353By similarity
    Disulfide bondi382 ↔ 389By similarity
    Glycosylationi509 – 5091N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PRIDEiA1DP75.

    Interactioni

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00004297.

    Structurei

    3D structure databases

    ProteinModelPortaliA1DP75.
    SMRiA1DP75. Positions 124-540.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2939.
    HOGENOMiHOG000198296.
    KOiK13289.
    OMAiWPGQKEY.
    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1DP75-1 [UniParc]FASTAAdd to Basket

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    MRVLPATLLV GAATAAAPPF QQILGLPKKG ADTLAKPLHD LQEQLKTLSG    50
    EARHLWDEVA NHFPNNMDHN PVFSLPKKHT RRPDSHWDHI VRGADVQSVW 100
    VTGASGEKER EIDGKLEAYD LRVKKTDPSA LGIDPGVKQY TGYLDDNEND 150
    KHLFYWFFES RNDPKNDPVV LWLNGGPGCS SLTGLFLELG PSSINEKIKP 200
    IYNDFAWNSN ASVIFLDQPV NVGYSYSGAA VSDTVAAGKD VYALLTLFFK 250
    QFPEYAKQDF HIAGESYAGH YIPVFASEIL SHKKRNINLK SVLIGNGLTD 300
    GLTQYDYYRP MACGEGGYPA VLDEASCQSM DNALPRCKSM IESCYNTESS 350
    WICVPASIYC NNALLGPYQR TGQNVYDIRG KCEDTSNLCY KGMGYVSEYL 400
    NKREVREAVG AEVDGYESCN FDINRNFLFH GDWMKPYHRL VPGLLEQIPV 450
    LIYAGDADFI CNWLGNKAWT EALEWPGQKE YAPLPLKDLV IEENEHKGKK 500
    IGQIKSHGNF TFMRLYGAGH MVPMDQPEAS LEFFNRWLGG EWF 543
    Length:543
    Mass (Da):60,942
    Last modified:January 23, 2007 - v1
    Checksum:iF20A7038AC2F12DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027698 Genomic DNA. Translation: EAW16596.1.
    RefSeqiXP_001258493.1. XM_001258492.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00004425; CADNFIAP00004297; CADNFIAG00004425.
    GeneIDi4585009.
    KEGGinfi:NFIA_059500.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027698 Genomic DNA. Translation: EAW16596.1 .
    RefSeqi XP_001258493.1. XM_001258492.1.

    3D structure databases

    ProteinModelPortali A1DP75.
    SMRi A1DP75. Positions 124-540.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00004297.

    Protein family/group databases

    MEROPSi S10.001.

    Proteomic databases

    PRIDEi A1DP75.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00004425 ; CADNFIAP00004297 ; CADNFIAG00004425 .
    GeneIDi 4585009.
    KEGGi nfi:NFIA_059500.

    Phylogenomic databases

    eggNOGi COG2939.
    HOGENOMi HOG000198296.
    KOi K13289.
    OMAi WPGQKEY.
    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiCBPYA_NEOFI
    AccessioniPrimary (citable) accession number: A1DP75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3