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A1DMX4

- EXGD_NEOFI

UniProt

A1DMX4 - EXGD_NEOFI

Protein

Probable glucan 1,3-beta-glucosidase D

Gene

exgD

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan By similarity.By similarity

    Catalytic activityi

    Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei600 – 6001Proton donorBy similarity
    Active sitei705 – 7051NucleophileBy similarity

    GO - Molecular functioni

    1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glucan 1,3-beta-glucosidase D (EC:3.2.1.58)
    Alternative name(s):
    Exo-1,3-beta-glucanase D
    Gene namesi
    Name:exgD
    ORF Names:NFIA_054930
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 834834Probable glucan 1,3-beta-glucosidase DPRO_0000395169Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi384 – 3841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi396 – 3961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi549 – 5491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi561 – 5611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi639 – 6391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi672 – 6721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi692 – 6921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00005040.

    Structurei

    3D structure databases

    ProteinModelPortaliA1DMX4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 306306CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini328 – 834507ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei307 – 32721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi6 – 174169Arg-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2730.
    HOGENOMiHOG000114462.
    KOiK01210.
    OMAiNIITHYG.
    OrthoDBiEOG7ZPNTV.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00150. Cellulase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1DMX4-1 [UniParc]FASTAAdd to Basket

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    MPSHSRSRDR YGGRDSDREA RYDYDYARRR YATDDNDDDY DDDELEHGLN    50
    ERRYRRDGYL PPRESRTRGY YERDAEGAAD EELLGDERNP GPRASRSYGH 100
    DYDARRGERS RAREAPRRSE RHRDRDREGQ SRRRAYEDDG RHRTRDGRRE 150
    RGRESDAEAR RSRRREAGRE TAARKHQSSD STNSASHLLS ADALARLGAQ 200
    YEKEERRKRE NAKDAAKAER KRQKKRAVVG EESRALRDPP GESHRDRTKA 250
    RVASGAYLEE GRSPEMQVRH RGGGGPAMEA RWRKEGSWGG TMDDAGGGRP 300
    FWKRKKWIGL GALILILVIV IPVAVVVSKK HDNKSDPADP QGTSPGKSNL 350
    DGLSHDSIPA YAQGTYLDPW TWYDTTDFNV TFTNETVGGL SIMGLNSTWD 400
    DSARPNDNVP PLNEPFPYGS QPIRGVNLGG WLSIEPFIVP SLFDSYSSVA 450
    GIIDEWTLSK RLGSSAARTL EKHYATFITE QDFADIRDAG LDHVRIQYSY 500
    WAVATYDDDP YVAKISWRYL LRAIEYCRKY GLRVKLDPHG IPGSQNGWNH 550
    SGREGVIGWL NGTDGELNRN RSLAVHDSVS KFFAQDRYKN IVTIYGLVNE 600
    PLMLSLSVED VLDWTTEATK LVQKNGITAY VALHDGFLNL SKWKSMLKNR 650
    PDKMLLDTHQ YTIFNTGQIG LNHTAKVNLI CNDWYNMIKE INSTSTGWGP 700
    TICGEWSQAD TDCAKYLNNV GRGTRWEGTF SLTDSTQYCP TADTGPPCSC 750
    ANANADVSEY SADYKKFLQT YAEAQMSAFE TGQGWFYWTW RTESAAQWSY 800
    RTAWKNGFMP AKAYAPSFKC GDAVPDFGNL PEYY 834
    Length:834
    Mass (Da):94,751
    Last modified:January 23, 2007 - v1
    Checksum:i3C79949E1E4CB32F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027698 Genomic DNA. Translation: EAW16145.1.
    RefSeqiXP_001258042.1. XM_001258041.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00005168; CADNFIAP00005040; CADNFIAG00005168.
    GeneIDi4584557.
    KEGGinfi:NFIA_054930.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027698 Genomic DNA. Translation: EAW16145.1 .
    RefSeqi XP_001258042.1. XM_001258041.1.

    3D structure databases

    ProteinModelPortali A1DMX4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00005040.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00005168 ; CADNFIAP00005040 ; CADNFIAG00005168 .
    GeneIDi 4584557.
    KEGGi nfi:NFIA_054930.

    Phylogenomic databases

    eggNOGi COG2730.
    HOGENOMi HOG000114462.
    KOi K01210.
    OMAi NIITHYG.
    OrthoDBi EOG7ZPNTV.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00150. Cellulase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiEXGD_NEOFI
    AccessioniPrimary (citable) accession number: A1DMX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3