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A1DMX4

- EXGD_NEOFI

UniProt

A1DMX4 - EXGD_NEOFI

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Protein
Probable glucan 1,3-beta-glucosidase D
Gene
exgD, NFIA_054930
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan By similarity.

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei600 – 6001Proton donor By similarity
Active sitei705 – 7051Nucleophile By similarity

GO - Molecular functioni

  1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase D (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase D
Gene namesi
Name:exgD
ORF Names:NFIA_054930
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 306306Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei307 – 32721Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini328 – 834507Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834Probable glucan 1,3-beta-glucosidase D
PRO_0000395169Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi333 – 3331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi379 – 3791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi384 – 3841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi396 – 3961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi549 – 5491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi561 – 5611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi570 – 5701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi639 – 6391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi672 – 6721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi692 – 6921N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00005040.

Structurei

3D structure databases

ProteinModelPortaliA1DMX4.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 174169Arg-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2730.
HOGENOMiHOG000114462.
KOiK01210.
OMAiNIITHYG.
OrthoDBiEOG7ZPNTV.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

A1DMX4-1 [UniParc]FASTAAdd to Basket

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MPSHSRSRDR YGGRDSDREA RYDYDYARRR YATDDNDDDY DDDELEHGLN    50
ERRYRRDGYL PPRESRTRGY YERDAEGAAD EELLGDERNP GPRASRSYGH 100
DYDARRGERS RAREAPRRSE RHRDRDREGQ SRRRAYEDDG RHRTRDGRRE 150
RGRESDAEAR RSRRREAGRE TAARKHQSSD STNSASHLLS ADALARLGAQ 200
YEKEERRKRE NAKDAAKAER KRQKKRAVVG EESRALRDPP GESHRDRTKA 250
RVASGAYLEE GRSPEMQVRH RGGGGPAMEA RWRKEGSWGG TMDDAGGGRP 300
FWKRKKWIGL GALILILVIV IPVAVVVSKK HDNKSDPADP QGTSPGKSNL 350
DGLSHDSIPA YAQGTYLDPW TWYDTTDFNV TFTNETVGGL SIMGLNSTWD 400
DSARPNDNVP PLNEPFPYGS QPIRGVNLGG WLSIEPFIVP SLFDSYSSVA 450
GIIDEWTLSK RLGSSAARTL EKHYATFITE QDFADIRDAG LDHVRIQYSY 500
WAVATYDDDP YVAKISWRYL LRAIEYCRKY GLRVKLDPHG IPGSQNGWNH 550
SGREGVIGWL NGTDGELNRN RSLAVHDSVS KFFAQDRYKN IVTIYGLVNE 600
PLMLSLSVED VLDWTTEATK LVQKNGITAY VALHDGFLNL SKWKSMLKNR 650
PDKMLLDTHQ YTIFNTGQIG LNHTAKVNLI CNDWYNMIKE INSTSTGWGP 700
TICGEWSQAD TDCAKYLNNV GRGTRWEGTF SLTDSTQYCP TADTGPPCSC 750
ANANADVSEY SADYKKFLQT YAEAQMSAFE TGQGWFYWTW RTESAAQWSY 800
RTAWKNGFMP AKAYAPSFKC GDAVPDFGNL PEYY 834
Length:834
Mass (Da):94,751
Last modified:January 23, 2007 - v1
Checksum:i3C79949E1E4CB32F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027698 Genomic DNA. Translation: EAW16145.1.
RefSeqiXP_001258042.1. XM_001258041.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00005168; CADNFIAP00005040; CADNFIAG00005168.
GeneIDi4584557.
KEGGinfi:NFIA_054930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027698 Genomic DNA. Translation: EAW16145.1 .
RefSeqi XP_001258042.1. XM_001258041.1.

3D structure databases

ProteinModelPortali A1DMX4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00005040.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00005168 ; CADNFIAP00005040 ; CADNFIAG00005168 .
GeneIDi 4584557.
KEGGi nfi:NFIA_054930.

Phylogenomic databases

eggNOGi COG2730.
HOGENOMi HOG000114462.
KOi K01210.
OMAi NIITHYG.
OrthoDBi EOG7ZPNTV.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiEXGD_NEOFI
AccessioniPrimary (citable) accession number: A1DMX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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