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Protein

Probable glucan 1,3-beta-glucosidase D

Gene

exgD

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan (By similarity).By similarity

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei600Proton donorBy similarity1
Active sitei705NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase D (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase D
Gene namesi
Name:exgD
ORF Names:NFIA_054930
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_054930

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 306CytoplasmicSequence analysisAdd BLAST306
Transmembranei307 – 327Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini328 – 834ExtracellularSequence analysisAdd BLAST507

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003951691 – 834Probable glucan 1,3-beta-glucosidase DAdd BLAST834

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi379N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi384N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi549N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi561N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi570N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi639N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi672N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi692N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00005040

Structurei

3D structure databases

ProteinModelPortaliA1DMX4
SMRiA1DMX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 174Arg-richAdd BLAST169

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000114462
KOiK01210
OMAiDNVPPLN
OrthoDBiEOG092C22A6

Family and domain databases

InterProiView protein in InterPro
IPR001547 Glyco_hydro_5
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00150 Cellulase, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

A1DMX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSHSRSRDR YGGRDSDREA RYDYDYARRR YATDDNDDDY DDDELEHGLN
60 70 80 90 100
ERRYRRDGYL PPRESRTRGY YERDAEGAAD EELLGDERNP GPRASRSYGH
110 120 130 140 150
DYDARRGERS RAREAPRRSE RHRDRDREGQ SRRRAYEDDG RHRTRDGRRE
160 170 180 190 200
RGRESDAEAR RSRRREAGRE TAARKHQSSD STNSASHLLS ADALARLGAQ
210 220 230 240 250
YEKEERRKRE NAKDAAKAER KRQKKRAVVG EESRALRDPP GESHRDRTKA
260 270 280 290 300
RVASGAYLEE GRSPEMQVRH RGGGGPAMEA RWRKEGSWGG TMDDAGGGRP
310 320 330 340 350
FWKRKKWIGL GALILILVIV IPVAVVVSKK HDNKSDPADP QGTSPGKSNL
360 370 380 390 400
DGLSHDSIPA YAQGTYLDPW TWYDTTDFNV TFTNETVGGL SIMGLNSTWD
410 420 430 440 450
DSARPNDNVP PLNEPFPYGS QPIRGVNLGG WLSIEPFIVP SLFDSYSSVA
460 470 480 490 500
GIIDEWTLSK RLGSSAARTL EKHYATFITE QDFADIRDAG LDHVRIQYSY
510 520 530 540 550
WAVATYDDDP YVAKISWRYL LRAIEYCRKY GLRVKLDPHG IPGSQNGWNH
560 570 580 590 600
SGREGVIGWL NGTDGELNRN RSLAVHDSVS KFFAQDRYKN IVTIYGLVNE
610 620 630 640 650
PLMLSLSVED VLDWTTEATK LVQKNGITAY VALHDGFLNL SKWKSMLKNR
660 670 680 690 700
PDKMLLDTHQ YTIFNTGQIG LNHTAKVNLI CNDWYNMIKE INSTSTGWGP
710 720 730 740 750
TICGEWSQAD TDCAKYLNNV GRGTRWEGTF SLTDSTQYCP TADTGPPCSC
760 770 780 790 800
ANANADVSEY SADYKKFLQT YAEAQMSAFE TGQGWFYWTW RTESAAQWSY
810 820 830
RTAWKNGFMP AKAYAPSFKC GDAVPDFGNL PEYY
Length:834
Mass (Da):94,751
Last modified:January 23, 2007 - v1
Checksum:i3C79949E1E4CB32F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027698 Genomic DNA Translation: EAW16145.1
RefSeqiXP_001258042.1, XM_001258041.1

Genome annotation databases

EnsemblFungiiCADNFIAT00005168; CADNFIAP00005040; CADNFIAG00005168
GeneIDi4584557
KEGGinfi:NFIA_054930

Similar proteinsi

Entry informationi

Entry nameiEXGD_NEOFI
AccessioniPrimary (citable) accession number: A1DMX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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