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Protein

Beta-mannosidase A

Gene

mndA

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathwayi: N-glycan degradation

This protein is involved in the pathway N-glycan degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway N-glycan degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei478Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00280

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-mannosidase A (EC:3.2.1.25)
Alternative name(s):
Mannanase A
Short name:
Mannase A
Gene namesi
Name:mndA
ORF Names:NFIA_054490
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_054490

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000039465022 – 930Beta-mannosidase AAdd BLAST909

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi281N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi346N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi536N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi607N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi630N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi657N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi737N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi760N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi782N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi789N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi797N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi823N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi909N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA1DMT2

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi36630.CADNFIAP00004919

Structurei

3D structure databases

ProteinModelPortaliA1DMT2
SMRiA1DMT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000216059
KOiK01192
OMAiCHATQLF
OrthoDBiEOG092C0Q54

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036156 Beta-gal/glucu_dom_sf
IPR008979 Galactose-bd-like_sf
IPR006102 Glyco_hydro_2_Ig-like
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00703 Glyco_hydro_2, 1 hit
SUPFAMiSSF49303 SSF49303, 2 hits
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1DMT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVKAETVLA LLTPGLPSVV GQHVVDLSGD GWTLSSTALD RTVPGHLPSQ
60 70 80 90 100
VHLDLFEAGV INITASMILT FVGLLMPIGR IPATRLKACD LENFESTWLV
110 120 130 140 150
FDGLDTFTTI TFCDQHVGST DNQFRQYHFD VSQILKECKQ DPVIRINFGS
160 170 180 190 200
APSIANAIAK SPDAEEWPPG VQITNEYPNR WYIRKEQSDF GWDWGPAFAP
210 220 230 240 250
VGPWKPSYIV QNNHAELYVL NTDLDFYRQG QINYLPPDQS QPWIVNASID
260 270 280 290 300
ILGPVPWKPS MSIEIKDAAT GSVLSSGLLQ NVTVSGNSIT GTTTIDGDAP
310 320 330 340 350
KLWWPSGMGE QNLYNVTVTV QNDKKKSLAK VTKRTGFRTI FLNQRNITDD
360 370 380 390 400
QLAQGIAPGA NWHFEINGHA FYAKGSNIIP PDAFWPRVTQ ARMARLFDAV
410 420 430 440 450
TAGNQNMLRV WASGAYLHDF IYDLADEKGI LLWSEFQFSD ALYPVNDAFL
460 470 480 490 500
ENVAAEVVYN VRRVNHHPSL ALWAGGNEIE SLMLPMVKRA DPTGYSKYVG
510 520 530 540 550
EYEKLYISLI LPLVYENTRS ITYSPSSTTE GYLYVNLSAP VPMAERYSNT
560 570 580 590 600
TPGSYYGDTD YYNYDTSVSF DYNHYPVGRF ANEFGFHSMP SLQTWQQAVD
610 620 630 640 650
PEDLHFNSSV VMLRNHHYTA GGLFTDNFKN SSKGMGEMTM GVEAYYPIPS
660 670 680 690 700
KSDSVANFSA WCHATQLFQA DMYKSQIQFY RRGSGMPERQ LGSLYWQLED
710 720 730 740 750
IWQAPTWAGI EYDGRWKVLH YVARDIYQPI IVSPFWNYTT GRLEVYVTSD
760 770 780 790 800
LWEPAQGTVN LTWVDLSGKT IANNAGTPET VNFTVGALNT TNIYTTNISE
810 820 830 840 850
LSLPDLKDSI LILSLSGEGR LPNTSSKKAF VHQNHFTPVF PKDLSLKDPK
860 870 880 890 900
LEISYSPESR KFTVQATGGV SLYTWLDYPA GAVGYFEENA FVLLPGVQKE
910 920 930
VSFAAQEGNV TDDWVRRVTV QSLWDQKVRD
Length:930
Mass (Da):104,276
Last modified:January 23, 2007 - v1
Checksum:i736EDACC02D252D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027698 Genomic DNA Translation: EAW16103.1
RefSeqiXP_001258000.1, XM_001257999.1

Genome annotation databases

EnsemblFungiiCADNFIAT00005047; CADNFIAP00004919; CADNFIAG00005047
GeneIDi4584515
KEGGinfi:NFIA_054490

Similar proteinsi

Entry informationi

Entry nameiMANBA_NEOFI
AccessioniPrimary (citable) accession number: A1DMT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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