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Protein

Beta-mannosidase A

Gene

mndA

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei478 – 4781Proton donorBy similarity

GO - Molecular functioni

  1. beta-mannosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00280.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-mannosidase A (EC:3.2.1.25)
Alternative name(s):
Mannanase A
Short name:
Mannase A
Gene namesi
Name:mndA
ORF Names:NFIA_054490
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_054490.

Subcellular locationi

  1. Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 930909Beta-mannosidase APRO_0000394650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi346 – 3461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi607 – 6071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi657 – 6571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi737 – 7371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi760 – 7601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi782 – 7821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi789 – 7891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi797 – 7971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi823 – 8231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi909 – 9091N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi36630.CADNFIAP00004919.

Structurei

3D structure databases

ProteinModelPortaliA1DMT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000216059.
KOiK01192.
OMAiCHATQLF.
OrthoDBiEOG78D7TH.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1DMT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVKAETVLA LLTPGLPSVV GQHVVDLSGD GWTLSSTALD RTVPGHLPSQ
60 70 80 90 100
VHLDLFEAGV INITASMILT FVGLLMPIGR IPATRLKACD LENFESTWLV
110 120 130 140 150
FDGLDTFTTI TFCDQHVGST DNQFRQYHFD VSQILKECKQ DPVIRINFGS
160 170 180 190 200
APSIANAIAK SPDAEEWPPG VQITNEYPNR WYIRKEQSDF GWDWGPAFAP
210 220 230 240 250
VGPWKPSYIV QNNHAELYVL NTDLDFYRQG QINYLPPDQS QPWIVNASID
260 270 280 290 300
ILGPVPWKPS MSIEIKDAAT GSVLSSGLLQ NVTVSGNSIT GTTTIDGDAP
310 320 330 340 350
KLWWPSGMGE QNLYNVTVTV QNDKKKSLAK VTKRTGFRTI FLNQRNITDD
360 370 380 390 400
QLAQGIAPGA NWHFEINGHA FYAKGSNIIP PDAFWPRVTQ ARMARLFDAV
410 420 430 440 450
TAGNQNMLRV WASGAYLHDF IYDLADEKGI LLWSEFQFSD ALYPVNDAFL
460 470 480 490 500
ENVAAEVVYN VRRVNHHPSL ALWAGGNEIE SLMLPMVKRA DPTGYSKYVG
510 520 530 540 550
EYEKLYISLI LPLVYENTRS ITYSPSSTTE GYLYVNLSAP VPMAERYSNT
560 570 580 590 600
TPGSYYGDTD YYNYDTSVSF DYNHYPVGRF ANEFGFHSMP SLQTWQQAVD
610 620 630 640 650
PEDLHFNSSV VMLRNHHYTA GGLFTDNFKN SSKGMGEMTM GVEAYYPIPS
660 670 680 690 700
KSDSVANFSA WCHATQLFQA DMYKSQIQFY RRGSGMPERQ LGSLYWQLED
710 720 730 740 750
IWQAPTWAGI EYDGRWKVLH YVARDIYQPI IVSPFWNYTT GRLEVYVTSD
760 770 780 790 800
LWEPAQGTVN LTWVDLSGKT IANNAGTPET VNFTVGALNT TNIYTTNISE
810 820 830 840 850
LSLPDLKDSI LILSLSGEGR LPNTSSKKAF VHQNHFTPVF PKDLSLKDPK
860 870 880 890 900
LEISYSPESR KFTVQATGGV SLYTWLDYPA GAVGYFEENA FVLLPGVQKE
910 920 930
VSFAAQEGNV TDDWVRRVTV QSLWDQKVRD
Length:930
Mass (Da):104,276
Last modified:January 23, 2007 - v1
Checksum:i736EDACC02D252D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027698 Genomic DNA. Translation: EAW16103.1.
RefSeqiXP_001258000.1. XM_001257999.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00005047; CADNFIAP00004919; CADNFIAG00005047.
GeneIDi4584515.
KEGGinfi:NFIA_054490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027698 Genomic DNA. Translation: EAW16103.1.
RefSeqiXP_001258000.1. XM_001257999.1.

3D structure databases

ProteinModelPortaliA1DMT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi36630.CADNFIAP00004919.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADNFIAT00005047; CADNFIAP00004919; CADNFIAG00005047.
GeneIDi4584515.
KEGGinfi:NFIA_054490.

Organism-specific databases

EuPathDBiFungiDB:NFIA_054490.

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000216059.
KOiK01192.
OMAiCHATQLF.
OrthoDBiEOG78D7TH.

Enzyme and pathway databases

UniPathwayiUPA00280.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00703. Glyco_hydro_2. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiMANBA_NEOFI
AccessioniPrimary (citable) accession number: A1DMT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.