Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A1DMT2

- MANBA_NEOFI

UniProt

A1DMT2 - MANBA_NEOFI

Protein

Beta-mannosidase A

Gene

mndA

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei478 – 4781Proton donorBy similarity

    GO - Molecular functioni

    1. beta-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00280.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-mannosidase A (EC:3.2.1.25)
    Alternative name(s):
    Mannanase A
    Short name:
    Mannase A
    Gene namesi
    Name:mndA
    ORF Names:NFIA_054490
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 930909Beta-mannosidase APRO_0000394650Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi346 – 3461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi607 – 6071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi630 – 6301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi657 – 6571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi737 – 7371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi760 – 7601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi782 – 7821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi789 – 7891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi797 – 7971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi823 – 8231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi909 – 9091N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00004919.

    Structurei

    3D structure databases

    ProteinModelPortaliA1DMT2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3250.
    HOGENOMiHOG000216059.
    KOiK01192.
    OMAiCHATQLF.
    OrthoDBiEOG78D7TH.

    Family and domain databases

    Gene3Di2.60.120.260. 2 hits.
    2.60.40.320. 1 hit.
    3.20.20.80. 2 hits.
    InterProiIPR008979. Galactose-bd-like.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00703. Glyco_hydro_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1DMT2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHVKAETVLA LLTPGLPSVV GQHVVDLSGD GWTLSSTALD RTVPGHLPSQ    50
    VHLDLFEAGV INITASMILT FVGLLMPIGR IPATRLKACD LENFESTWLV 100
    FDGLDTFTTI TFCDQHVGST DNQFRQYHFD VSQILKECKQ DPVIRINFGS 150
    APSIANAIAK SPDAEEWPPG VQITNEYPNR WYIRKEQSDF GWDWGPAFAP 200
    VGPWKPSYIV QNNHAELYVL NTDLDFYRQG QINYLPPDQS QPWIVNASID 250
    ILGPVPWKPS MSIEIKDAAT GSVLSSGLLQ NVTVSGNSIT GTTTIDGDAP 300
    KLWWPSGMGE QNLYNVTVTV QNDKKKSLAK VTKRTGFRTI FLNQRNITDD 350
    QLAQGIAPGA NWHFEINGHA FYAKGSNIIP PDAFWPRVTQ ARMARLFDAV 400
    TAGNQNMLRV WASGAYLHDF IYDLADEKGI LLWSEFQFSD ALYPVNDAFL 450
    ENVAAEVVYN VRRVNHHPSL ALWAGGNEIE SLMLPMVKRA DPTGYSKYVG 500
    EYEKLYISLI LPLVYENTRS ITYSPSSTTE GYLYVNLSAP VPMAERYSNT 550
    TPGSYYGDTD YYNYDTSVSF DYNHYPVGRF ANEFGFHSMP SLQTWQQAVD 600
    PEDLHFNSSV VMLRNHHYTA GGLFTDNFKN SSKGMGEMTM GVEAYYPIPS 650
    KSDSVANFSA WCHATQLFQA DMYKSQIQFY RRGSGMPERQ LGSLYWQLED 700
    IWQAPTWAGI EYDGRWKVLH YVARDIYQPI IVSPFWNYTT GRLEVYVTSD 750
    LWEPAQGTVN LTWVDLSGKT IANNAGTPET VNFTVGALNT TNIYTTNISE 800
    LSLPDLKDSI LILSLSGEGR LPNTSSKKAF VHQNHFTPVF PKDLSLKDPK 850
    LEISYSPESR KFTVQATGGV SLYTWLDYPA GAVGYFEENA FVLLPGVQKE 900
    VSFAAQEGNV TDDWVRRVTV QSLWDQKVRD 930
    Length:930
    Mass (Da):104,276
    Last modified:January 23, 2007 - v1
    Checksum:i736EDACC02D252D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027698 Genomic DNA. Translation: EAW16103.1.
    RefSeqiXP_001258000.1. XM_001257999.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00005047; CADNFIAP00004919; CADNFIAG00005047.
    GeneIDi4584515.
    KEGGinfi:NFIA_054490.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027698 Genomic DNA. Translation: EAW16103.1 .
    RefSeqi XP_001258000.1. XM_001257999.1.

    3D structure databases

    ProteinModelPortali A1DMT2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00004919.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00005047 ; CADNFIAP00004919 ; CADNFIAG00005047 .
    GeneIDi 4584515.
    KEGGi nfi:NFIA_054490.

    Phylogenomic databases

    eggNOGi COG3250.
    HOGENOMi HOG000216059.
    KOi K01192.
    OMAi CHATQLF.
    OrthoDBi EOG78D7TH.

    Enzyme and pathway databases

    UniPathwayi UPA00280 .

    Family and domain databases

    Gene3Di 2.60.120.260. 2 hits.
    2.60.40.320. 1 hit.
    3.20.20.80. 2 hits.
    InterProi IPR008979. Galactose-bd-like.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00703. Glyco_hydro_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiMANBA_NEOFI
    AccessioniPrimary (citable) accession number: A1DMT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3