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A1DMR2

- PMIP_NEOFI

UniProt

A1DMR2 - PMIP_NEOFI

Protein

Mitochondrial intermediate peptidase

Gene

oct1

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi565 – 5651Zinc; catalyticPROSITE-ProRule annotation
    Active sitei566 – 5661PROSITE-ProRule annotation
    Metal bindingi569 – 5691Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi572 – 5721Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:oct1
    ORF Names:NFIA_054290
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4242MitochondrionSequence AnalysisAdd
    BLAST
    Chaini43 – 801759Mitochondrial intermediate peptidasePRO_0000338589Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00004862.

    Structurei

    3D structure databases

    ProteinModelPortaliA1DMR2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0339.
    HOGENOMiHOG000076521.
    KOiK01410.
    OMAiQMSTHEE.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1DMR2-1 [UniParc]FASTAAdd to Basket

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    MKDQLLVPLR RRPWTCRKCL QRLQLLPQHQ TRRSFETAAS PFPRQLDSLP    50
    ADYSRTKTVD DDTLRRVFDS QQFWREFSQQ RSAQPKPTGL VQNQYLTSPD 100
    GFRTFANVSL QKCQAIVSKV LAASTLEEYR TMARDLDRLS DLLCRVIDLS 150
    DFIRVIHPDP QVQEAATQAY ALMFEYMNVL NTTTGLNDQL KKAAANPEVT 200
    SQWSDEEKIV AQILIKDFSN SAIHMPPHER QRFVNLSNDI SQLGSSFVNG 250
    AEPAKSHVSV ATNNLRGLDP ILVQQIKRWN RTAAVPTTGM IPRLALRSVH 300
    DENVRREVYL ASRTSSKRQL HRLEELLLKR AELAKLSGYE SFAHMTLSDK 350
    MAKSPEAVSN FLTALVDSNR KLVREELSQL QAMKGAPLQP WDHAYYVHQR 400
    VMQYSQARRS RELSAVPEFF SLGTVMQGLS RLFDRLYGVR LVPQEPAPGE 450
    TWNPDVRRLD VVDESGRHIA VIYCDLFSRP NKHPNPAHFT LRCSREISTE 500
    EVAECASLDQ SSHPNDGMAT AVDPVTKTLR QLPTIALVCD FSEPGTNGGG 550
    RPSLLSEHSV RTLFHEMGHA VHSILGQTRL QSISGTRCAT DFAELPSVLM 600
    EHFATAPSVL ALYARHWRTD EPLSEGMIRS MERDRTAHGS IYGAVENEAQ 650
    ILMALVDQAY HSRPADGGRI DSTALYQQVS QQHSSLPEPA DVTPPTSWQG 700
    FFGHLYGYGA TYYSYIFDRA IANKLWVDVF GAGRQAVDRA AGERYKNEVL 750
    RWGGGRSGWE CVAGALGSAN ESNADGRLVE GGDEAMREVG RWGLGRDGVS 800
    G 801
    Length:801
    Mass (Da):89,774
    Last modified:January 23, 2007 - v1
    Checksum:i906514456D11365F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027698 Genomic DNA. Translation: EAW16083.1.
    RefSeqiXP_001257980.1. XM_001257979.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00004990; CADNFIAP00004862; CADNFIAG00004990.
    GeneIDi4584495.
    KEGGinfi:NFIA_054290.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027698 Genomic DNA. Translation: EAW16083.1 .
    RefSeqi XP_001257980.1. XM_001257979.1.

    3D structure databases

    ProteinModelPortali A1DMR2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00004862.

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00004990 ; CADNFIAP00004862 ; CADNFIAG00004990 .
    GeneIDi 4584495.
    KEGGi nfi:NFIA_054290.

    Phylogenomic databases

    eggNOGi COG0339.
    HOGENOMi HOG000076521.
    KOi K01410.
    OMAi QMSTHEE.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiPMIP_NEOFI
    AccessioniPrimary (citable) accession number: A1DMR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3