ID   MCES_NEOFI              Reviewed;         667 AA.
AC   A1DMG9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   16-JUN-2009, entry version 17.
DE   RecName: Full=mRNA cap guanine-N7 methyltransferase;
DE            EC=2.1.1.56;
DE   AltName: Full=mRNA (guanine-N(7)-)-methyltransferase;
DE   AltName: Full=mRNA cap methyltransferase;
GN   Name=abd1; ORFNames=NFIA_053360;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL
OS   181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Neosartorya.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P.,
RA   Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A.,
RA   Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A.,
RA   Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R.,
RA   Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M.,
RA   Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R.,
RA   Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R.,
RA   Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Responsible for methylating the 5'-cap structure of
CC       mRNAs (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + G(5')pppR-RNA = S-
CC       adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- SIMILARITY: Belongs to the mRNA cap methyltransferase family.
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DR   EMBL; DS027698; EAW15990.1; -; Genomic_DNA.
DR   RefSeq; XP_001257887.1; -.
DR   GeneID; 4584402; -.
DR   KEGG; nfi:NFIA_053360; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004482; F:mRNA (guanine-N7-)-methyltransferase activity; IEA:EC.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006370; P:mRNA capping; IEA:UniProtKB-KW.
DR   InterPro; IPR004971; Pox_MCEL.
DR   Pfam; PF03291; Pox_MCEL; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Methyltransferase; mRNA capping; mRNA processing;
KW   Nucleus; RNA-binding; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    667       mRNA cap guanine-N7 methyltransferase.
FT                                /FTId=PRO_0000303912.
SQ   SEQUENCE   667 AA;  74708 MW;  C5BEEBF6B08912A0 CRC64;
     MYDPARDSWE ERDGDEARSL RGRLASDQPH AGFSSSEQIY GASGENNNTT DLQHPGPDPK
     TTASAKVLYA ESPPAQSTTQ TPPSISTHVQ SPVNPAAQEA SNTQSLTSAA QNQSNKSTTT
     MDNTSGSATP KPRADPSDKS NRPDQVASPT DQNGSQGDKK RKVPAEENAS EKSQPTPDRP
     VSKRKRMEER HQKLRKRGRT PPSAYSRRDA DETASAADRN GPTYRSTSPL PPPRSPTPED
     QPRQRKRPGG GARMGLVDRE TLRRRQEERE RAQVEEAMRA SQGRGLADVV RQHYNAVPQR
     GREWRKTESK IKGLRSFNNW IKSTLIQKFS PDEEFLARFN GTKDWAEDGG VPPVEEKRLL
     VIDLGCGKGG DLLKWQLAPQ PVDLYVGLDP AEVSIVQARE RYNGMKSGRG NRGRRNPIFH
     AEFQPKDCFG EWLGDVDIVQ QVGIDPNVGP GGSVMSSRWG GGGFDVVASM FTIHYAFESE
     EKARQMLRNV AGCLKKGGRF LGVCPNSDVI SARVSEINAK KKERQSQAKK EKTDEAPEDG
     EVEEDDGKVE WGNQIYRVRF PVTTPEDGIF RPPFGWKYSY FMEEAVEEVP EYVVPWEAFR
     ALTEDYNLEL QYRKPFLDIW RDEKDDPELG PLSERMGVRD RATGELLMTE EEKEAASFYH
     AFCFYKV
//