Reviewed, UniProtKB/Swiss-Prot A1DMG9 (MCES_NEOFI)

Names and origin

Protein names

Recommended name:
    mRNA cap guanine-N7 methyltransferase
    EC=2.1.1.56
Alternative name(s):
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap methyltransferase

Gene names

Name:	abd1
ORF Names:	NFIA_053360

Organism

Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]

Taxonomic identifier

331117 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Neosartorya

Protein attributes

Sequence length	667 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Responsible for methylating the 5'-cap structure of mRNAs By similarity.
Catalytic activity	S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the mRNA cap methyltransferase family.

Ontologies

Keywords
Biological process	mRNA capping mRNA processing
Cellular component	Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA capping Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA (guanine-N7-)-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 667	667	mRNA cap guanine-N7 methyltransferase		PRO_0000303912

Sequences

	Sequence		Length	Mass (Da)
	A1DMG9-1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: C5BEEBF6B08912A0	FASTA	667	74,708
	10 20 30 40 50 60 MYDPARDSWE ERDGDEARSL RGRLASDQPH AGFSSSEQIY GASGENNNTT DLQHPGPDPK 70 80 90 100 110 120 TTASAKVLYA ESPPAQSTTQ TPPSISTHVQ SPVNPAAQEA SNTQSLTSAA QNQSNKSTTT 130 140 150 160 170 180 MDNTSGSATP KPRADPSDKS NRPDQVASPT DQNGSQGDKK RKVPAEENAS EKSQPTPDRP 190 200 210 220 230 240 VSKRKRMEER HQKLRKRGRT PPSAYSRRDA DETASAADRN GPTYRSTSPL PPPRSPTPED 250 260 270 280 290 300 QPRQRKRPGG GARMGLVDRE TLRRRQEERE RAQVEEAMRA SQGRGLADVV RQHYNAVPQR 310 320 330 340 350 360 GREWRKTESK IKGLRSFNNW IKSTLIQKFS PDEEFLARFN GTKDWAEDGG VPPVEEKRLL 370 380 390 400 410 420 VIDLGCGKGG DLLKWQLAPQ PVDLYVGLDP AEVSIVQARE RYNGMKSGRG NRGRRNPIFH 430 440 450 460 470 480 AEFQPKDCFG EWLGDVDIVQ QVGIDPNVGP GGSVMSSRWG GGGFDVVASM FTIHYAFESE 490 500 510 520 530 540 EKARQMLRNV AGCLKKGGRF LGVCPNSDVI SARVSEINAK KKERQSQAKK EKTDEAPEDG 550 560 570 580 590 600 EVEEDDGKVE WGNQIYRVRF PVTTPEDGIF RPPFGWKYSY FMEEAVEEVP EYVVPWEAFR 610 620 630 640 650 660 ALTEDYNLEL QYRKPFLDIW RDEKDDPELG PLSERMGVRD RATGELLMTE EEKEAASFYH AFCFYKV

References

[1]

"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M. , Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C. PLoS Genet. 4:E1000046-E1000046(2008) [PubMed: 18404212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DS027698 Genomic DNA. Translation: EAW15990.1.
RefSeq	XP_001257887.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4584402.
KEGG	nfi:NFIA_053360.
Family and domain databases
InterPro	IPR004971. Pox_MCEL. [Graphical view]
Pfam	PF03291. Pox_MCEL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MCES_NEOFI

Accession

Primary (citable) accession number: A1DMG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)