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A1DME8

- EGLB_NEOFI

UniProt

A1DME8 - EGLB_NEOFI

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Protein

Probable endo-beta-1,4-glucanase B

Gene

eglB

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates By similarity.By similarity

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei156 – 1561Proton donorBy similarity
Active sitei263 – 2631NucleophileBy similarity

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endo-beta-1,4-glucanase B (EC:3.2.1.4)
Short name:
Endoglucanase B
Alternative name(s):
Carboxymethylcellulase B
Cellulase B
Gene namesi
Name:eglB
ORF Names:NFIA_053150
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 329311Probable endo-beta-1,4-glucanase BPRO_0000394059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00005314.

Structurei

3D structure databases

ProteinModelPortaliA1DME8.
SMRiA1DME8. Positions 26-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2730.
HOGENOMiHOG000111120.
KOiK01179.
OMAiGKGMNIF.
OrthoDBiEOG776T0S.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1DME8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFGSIVLIA AAAGSAVAAP AKRASVFQWF GSNESGAEFG QNTIPGSYGK
60 70 80 90 100
EFIFPDPSTI STLIGKGMNI FRVQFLMERL VPSSMTGSYN EEYLANLTSV
110 120 130 140 150
VDAVTKAGSY AILDPHNFGR YNGQIISSTD DFKTFWQNLA GKFKSNNLVI
160 170 180 190 200
FDTNNEYHDM DQALVLNLNQ AAINGIRAAG ATSQYIFVEG NSWSGAWTWV
210 220 230 240 250
DVNDNLKALT DPQDKIVYEM HQYLDSDGSG TSESCVSTTI GKERVTAATK
260 270 280 290 300
WLKDNGKVGI IGEFAGGVND QCRTAISGML EYLAQNTDVW KGALWWAAGP
310 320
WWGNYMFNME PPSGAAYVGM LDILEPYLG
Length:329
Mass (Da):35,875
Last modified:January 23, 2007 - v1
Checksum:iDFA67E1E6BFA5E3F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027698 Genomic DNA. Translation: EAW15969.1.
RefSeqiXP_001257866.1. XM_001257865.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00005442; CADNFIAP00005314; CADNFIAG00005442.
GeneIDi4584381.
KEGGinfi:NFIA_053150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027698 Genomic DNA. Translation: EAW15969.1 .
RefSeqi XP_001257866.1. XM_001257865.1.

3D structure databases

ProteinModelPortali A1DME8.
SMRi A1DME8. Positions 26-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00005314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00005442 ; CADNFIAP00005314 ; CADNFIAG00005442 .
GeneIDi 4584381.
KEGGi nfi:NFIA_053150.

Phylogenomic databases

eggNOGi COG2730.
HOGENOMi HOG000111120.
KOi K01179.
OMAi GKGMNIF.
OrthoDBi EOG776T0S.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiEGLB_NEOFI
AccessioniPrimary (citable) accession number: A1DME8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3