Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82SubstrateBy similarity1
Binding sitei127SubstrateBy similarity1
Binding sitei128Substrate; via amide nitrogenBy similarity1
Binding sitei129SubstrateBy similarity1
Binding sitei187SubstrateBy similarity1
Active sitei188Proton donorSequence analysis1
Binding sitei251SubstrateBy similarity1
Active sitei287NucleophileSequence analysis1
Binding sitei353SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:NFIA_052310
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_052310.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000039523924 – 983Probable beta-galactosidase CAdd BLAST960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi257 ↔ 304By similarity
Glycosylationi276N-linked (GlcNAc...)Sequence analysis1
Glycosylationi391N-linked (GlcNAc...)Sequence analysis1
Glycosylationi434N-linked (GlcNAc...)Sequence analysis1
Glycosylationi466N-linked (GlcNAc...)Sequence analysis1
Glycosylationi516N-linked (GlcNAc...)Sequence analysis1
Glycosylationi601N-linked (GlcNAc...)Sequence analysis1
Glycosylationi676N-linked (GlcNAc...)Sequence analysis1
Glycosylationi714N-linked (GlcNAc...)Sequence analysis1
Glycosylationi719N-linked (GlcNAc...)Sequence analysis1
Glycosylationi804N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliA1DM65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000181922.
OMAiPVRGPMN.
OrthoDBiEOG092C0SLI.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 2 hits.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1DM65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIFSFLFLL LLGILTGQGL VSGTDNGKTT DVTWDKYSLS VKGQRLFVFS
60 70 80 90 100
GEFHYQRLPV PELWLDVFQK LRANGFNAIS VYFFWSFHSA SEGEFDFENG
110 120 130 140 150
AHDIQRLFDY AKEAGLYVIA RAGPYCNAET SAGGFALWAA NGQMGNERTS
160 170 180 190 200
DEAYYEKWRP WILEVGKIIA KNQITNGGPV ILNQHENELT ETTYDPNHTL
210 220 230 240 250
VVYMKQIAQV FEEAGIVVPS SHNEKGMRGV SWSTDYHNVG GAVNIYGLDS
260 270 280 290 300
YPGGLSCTNP NSGFRLVRTY YQWFQNYSST QPSYMPEFEG GWFQPWGGSF
310 320 330 340 350
YDTCATELSP EFPDVYYKNN IGSRVTLHSI YMTYGGTNWG HSAAPVVYTS
360 370 380 390 400
YDYAAPLRET REIRDKLKQT KLIGLFTRVS TDLLKTYMEG NGTGYTSDSS
410 420 430 440 450
IYTWSLRNPD TNAGFYVLAH STSSARDVTT FSLNATTSAG AISIPDIELN
460 470 480 490 500
GRQSKIIVTD YNFGTNSTLL FSSAEVLTYA NLDVNVLVFY LNVGQKGTFA
510 520 530 540 550
LKDEPKLAFQ TYGNSNVTTS ESSYGTQYSY TQGEGVTAVK FSNGVLAYLL
560 570 580 590 600
DKESAWNFFA PPTTSSPQVA PNEHILVQGP YLVRGASINH GTVEITGDNA
610 620 630 640 650
NTTSIEVYTG NSQVKKVKWN GKTIETRKTA YGSLIGTVPG AEDVKIRLPS
660 670 680 690 700
LDSWKAQDTL PEIQPDYDDS TWTVCNKTTS VNAIAPLSLP VLYSGDYGYH
710 720 730 740 750
AGTKVYRGRF DGRNVTGANV TVQNGAAAGW AAWVNGQYAG GSAGSPSLAA
760 770 780 790 800
TSAVLTFNGL SLKDRDNVLT VVTDYTGHDQ NSVRPKGTQN PRGILGATLT
810 820 830 840 850
GGGNFTSWRI QGNAGGEKNI DPVRGPMNEG GLYGERMGWH LPGYKVPKSA
860 870 880 890 900
SKSSPLDGVS GAEGRFYTTT FKLKLDKDLD VPIGLQLGAP EGTKAVVQVF
910 920 930 940 950
MNGYQFGHYL PHTGPQSLFP FPPGVINNRG ENTLAISMWA LTDAGAKLDK
960 970 980
VELVAYGKYR SGFDFNQDWG YLQPGWKDRS QYA
Length:983
Mass (Da):107,868
Last modified:January 23, 2007 - v1
Checksum:iDE259315212C11F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027698 Genomic DNA. Translation: EAW15886.1.
RefSeqiXP_001257783.1. XM_001257782.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00004593; CADNFIAP00004465; CADNFIAG00004593.
GeneIDi4584298.
KEGGinfi:NFIA_052310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027698 Genomic DNA. Translation: EAW15886.1.
RefSeqiXP_001257783.1. XM_001257782.1.

3D structure databases

ProteinModelPortaliA1DM65.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADNFIAT00004593; CADNFIAP00004465; CADNFIAG00004593.
GeneIDi4584298.
KEGGinfi:NFIA_052310.

Organism-specific databases

EuPathDBiFungiDB:NFIA_052310.

Phylogenomic databases

HOGENOMiHOG000181922.
OMAiPVRGPMN.
OrthoDBiEOG092C0SLI.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR031330. Gly_Hdrlase_35_cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 2 hits.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBGALC_NEOFI
AccessioniPrimary (citable) accession number: A1DM65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.