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A1DM65 (BGALC_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-galactosidase C

EC=3.2.1.23
Alternative name(s):
Lactase C
Gene names
Name:lacC
ORF Names:NFIA_052310
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]
Taxonomic identifier331117 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya

Protein attributes

Sequence length983 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 35 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpolysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 983960Probable beta-galactosidase C
PRO_0000395239

Sites

Active site1881Proton donor Potential
Active site2871Nucleophile Potential
Binding site821Substrate By similarity
Binding site1271Substrate By similarity
Binding site1281Substrate; via amide nitrogen By similarity
Binding site1291Substrate By similarity
Binding site1871Substrate By similarity
Binding site2511Substrate By similarity
Binding site3531Substrate By similarity

Amino acid modifications

Glycosylation1971N-linked (GlcNAc...) Potential
Glycosylation2761N-linked (GlcNAc...) Potential
Glycosylation3911N-linked (GlcNAc...) Potential
Glycosylation4341N-linked (GlcNAc...) Potential
Glycosylation4661N-linked (GlcNAc...) Potential
Glycosylation5161N-linked (GlcNAc...) Potential
Glycosylation6011N-linked (GlcNAc...) Potential
Glycosylation6761N-linked (GlcNAc...) Potential
Glycosylation7141N-linked (GlcNAc...) Potential
Glycosylation7191N-linked (GlcNAc...) Potential
Glycosylation8041N-linked (GlcNAc...) Potential
Disulfide bond257 ↔ 304 By similarity

Sequences

Sequence LengthMass (Da)Tools
A1DM65 [UniParc].

Last modified January 23, 2007. Version 1.
Checksum: DE259315212C11F0

FASTA983107,868
        10         20         30         40         50         60 
MRIFSFLFLL LLGILTGQGL VSGTDNGKTT DVTWDKYSLS VKGQRLFVFS GEFHYQRLPV 

        70         80         90        100        110        120 
PELWLDVFQK LRANGFNAIS VYFFWSFHSA SEGEFDFENG AHDIQRLFDY AKEAGLYVIA 

       130        140        150        160        170        180 
RAGPYCNAET SAGGFALWAA NGQMGNERTS DEAYYEKWRP WILEVGKIIA KNQITNGGPV 

       190        200        210        220        230        240 
ILNQHENELT ETTYDPNHTL VVYMKQIAQV FEEAGIVVPS SHNEKGMRGV SWSTDYHNVG 

       250        260        270        280        290        300 
GAVNIYGLDS YPGGLSCTNP NSGFRLVRTY YQWFQNYSST QPSYMPEFEG GWFQPWGGSF 

       310        320        330        340        350        360 
YDTCATELSP EFPDVYYKNN IGSRVTLHSI YMTYGGTNWG HSAAPVVYTS YDYAAPLRET 

       370        380        390        400        410        420 
REIRDKLKQT KLIGLFTRVS TDLLKTYMEG NGTGYTSDSS IYTWSLRNPD TNAGFYVLAH 

       430        440        450        460        470        480 
STSSARDVTT FSLNATTSAG AISIPDIELN GRQSKIIVTD YNFGTNSTLL FSSAEVLTYA 

       490        500        510        520        530        540 
NLDVNVLVFY LNVGQKGTFA LKDEPKLAFQ TYGNSNVTTS ESSYGTQYSY TQGEGVTAVK 

       550        560        570        580        590        600 
FSNGVLAYLL DKESAWNFFA PPTTSSPQVA PNEHILVQGP YLVRGASINH GTVEITGDNA 

       610        620        630        640        650        660 
NTTSIEVYTG NSQVKKVKWN GKTIETRKTA YGSLIGTVPG AEDVKIRLPS LDSWKAQDTL 

       670        680        690        700        710        720 
PEIQPDYDDS TWTVCNKTTS VNAIAPLSLP VLYSGDYGYH AGTKVYRGRF DGRNVTGANV 

       730        740        750        760        770        780 
TVQNGAAAGW AAWVNGQYAG GSAGSPSLAA TSAVLTFNGL SLKDRDNVLT VVTDYTGHDQ 

       790        800        810        820        830        840 
NSVRPKGTQN PRGILGATLT GGGNFTSWRI QGNAGGEKNI DPVRGPMNEG GLYGERMGWH 

       850        860        870        880        890        900 
LPGYKVPKSA SKSSPLDGVS GAEGRFYTTT FKLKLDKDLD VPIGLQLGAP EGTKAVVQVF 

       910        920        930        940        950        960 
MNGYQFGHYL PHTGPQSLFP FPPGVINNRG ENTLAISMWA LTDAGAKLDK VELVAYGKYR 

       970        980 
SGFDFNQDWG YLQPGWKDRS QYA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS027698 Genomic DNA. Translation: EAW15886.1.
RefSeqXP_001257783.1. XM_001257782.1.

3D structure databases

ProteinModelPortalA1DM65.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING36630.CADNFIAP00004465.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADNFIAT00004593; CADNFIAP00004465; CADNFIAG00004593.
GeneID4584298.
KEGGnfi:NFIA_052310.

Phylogenomic databases

eggNOGCOG1874.
HOGENOMHOG000181922.
OMASGEFHYQ.
OrthoDBEOG7ZGXBD.

Family and domain databases

Gene3D2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR23421. PTHR23421. 1 hit.
PfamPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSPR00742. GLHYDRLASE35.
SMARTSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBGALC_NEOFI
AccessionPrimary (citable) accession number: A1DM65
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries