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A1DM29

- A1DM29_NEOFI

UniProt

A1DM29 - A1DM29_NEOFI

Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

NFIA_051950

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
    2. nucleic acid binding Source: InterPro
    3. nucleotide binding Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Gene namesi
    ORF Names:NFIA_051950Imported
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)Imported
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-KW
    2. Set1C/COMPASS complex Source: InterPro

    Keywords - Cellular componenti

    ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Component of the COMPASS (Set1C) complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi36630.CADNFIAP00004585.

    Structurei

    3D structure databases

    ProteinModelPortaliA1DM29.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000181654.
    KOiK11422.
    OMAiDKTGYYI.
    OrthoDBiEOG7P8PH3.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTiSM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1DM29-1 [UniParc]FASTAAdd to Basket

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    MSRTSAGFAD FFPTAPSVLQ QKRVRAPRDR SRSKDRPEDQ LQVQDGNGQL     50
    ACSSGASAAN VSTNGSPPSV SVSETGTGVE KPGCKLVEET NTDITGTDTS 100
    ILSASLAQCR ATQVNEARFD NLTPVTNAES SPPRKLSPHQ SKSVSVAEYE 150
    SNKFATDELK LAATPLHTPP TPRSQTSRSG VIKGCKLVYD PDLEKRSSKE 200
    KRRKPQYVDF VVNEQDGCSP DPRLSILNYT RGAGCKQKTK YRPAPYRLKQ 250
    WPYDTATTIG PGPPVQIVVT GFDPLTPVAP INALFSSFGE ISEINNRTDP 300
    ITGRFLGVCS VKYKDSTSFR GAGPIPAATA ARRAYVECKK EQRIGTRRIR 350
    VELDRDGAVS DRIVARAIES QRMGHKKNTV GEEAKIEPQA KKNEPPPTAP 400
    KGPSRSSTRP AAAVPEGPRA SFLKPAMPSL IEETPILGQI KRDPYIFIAH 450
    CYVPVLSTTI PHLKKRLKLF DWKDIRCDKT GYYIIFENSR RGEEETERCF 500
    KVCHMKPLFT YIMNMESQPY GNPNYERSPS PERLQAERRE RAERERLKKE 550
    ADLDLEEEKK QRAIDLDPCR EVLALIVRDL KDKLLEDVKS RIAAPTLYDY 600
    LDPDRHAARR RALGIPDPEG IRRHTFQLDV DIFGSNNPQS SLPGGRSFSP 650
    YGLNILALPR IRKARRLNRA HAAFLDERRK QPVRRKEVRP LYHRLQQLHD 700
    VDDSDEDQRT PFSRDIDEQD SRPPSRMSSR SSISDDGEES EPLDGLASQD 750
    KRHEARLLGL EYGDSGTTLN ETVDGYSRHD SPGLSSTRKR KRLAEGIEVR 800
    KRPKEESERS ELNRSVETEN TLFYEESQHS EAAELGAVKP ENLAGIGGKF 850
    LGRLEDRSIK EDGEKENVER LQIKSAIQGA DLDVQPPLPD ESTIAKSHED 900
    PITEIEWGVS NDEPRPTVDD DETIILDLDG WQNLVKDEED LCFLRHVLDG 950
    QSRSKVGNLS AWAWRQKEIK ALNRPGESGP VHQETRIPDY YVCNPTGAAR 1000
    TEGRKRILES EKSKYLPHRI KVQKAREERE ANAKSDPHAS AAEAARISAA 1050
    KTISKSTSRS TRVNNRRLVA DINAQKQALP MQGGDGDVLR FNQLKKRKKP 1100
    VRFARSAIHN WGLYAEENIS ANDMIIEYVG EKVRQQVADM RERQYLKSGI 1150
    GSSYLFRIDE NTVIDATKRG GIARFINHSC TPNCTAKIIK VDGSKRIVIY 1200
    ALRDIGRDEE LTYDYKFERE WDSDDRIPCL CGSTGCKGFL N 1241
    Length:1,241
    Mass (Da):139,380
    Last modified:January 23, 2007 - v1
    Checksum:i5410637BC4667BFE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027698 Genomic DNA. Translation: EAW15850.1.
    RefSeqiXP_001257747.1. XM_001257746.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00004713; CADNFIAP00004585; CADNFIAG00004713.
    GeneIDi4584262.
    KEGGinfi:NFIA_051950.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027698 Genomic DNA. Translation: EAW15850.1 .
    RefSeqi XP_001257747.1. XM_001257746.1.

    3D structure databases

    ProteinModelPortali A1DM29.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 36630.CADNFIAP00004585.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00004713 ; CADNFIAP00004585 ; CADNFIAG00004713 .
    GeneIDi 4584262.
    KEGGi nfi:NFIA_051950.

    Phylogenomic databases

    HOGENOMi HOG000181654.
    KOi K11422.
    OMAi DKTGYYI.
    OrthoDBi EOG7P8PH3.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTi SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181Imported.

    Entry informationi

    Entry nameiA1DM29_NEOFI
    AccessioniPrimary (citable) accession number: A1DM29
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3