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A1DM29

- A1DM29_NEOFI

UniProt

A1DM29 - A1DM29_NEOFI

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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

NFIA_051950

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. nucleic acid binding Source: InterPro
  3. nucleotide binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Gene namesi
ORF Names:NFIA_051950Imported
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)Imported
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.UniRule annotation

Protein-protein interaction databases

STRINGi36630.CADNFIAP00004585.

Structurei

3D structure databases

ProteinModelPortaliA1DM29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000181654.
KOiK11422.
OMAiDKTGYYI.
OrthoDBiEOG7P8PH3.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1DM29-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRTSAGFAD FFPTAPSVLQ QKRVRAPRDR SRSKDRPEDQ LQVQDGNGQL
60 70 80 90 100
ACSSGASAAN VSTNGSPPSV SVSETGTGVE KPGCKLVEET NTDITGTDTS
110 120 130 140 150
ILSASLAQCR ATQVNEARFD NLTPVTNAES SPPRKLSPHQ SKSVSVAEYE
160 170 180 190 200
SNKFATDELK LAATPLHTPP TPRSQTSRSG VIKGCKLVYD PDLEKRSSKE
210 220 230 240 250
KRRKPQYVDF VVNEQDGCSP DPRLSILNYT RGAGCKQKTK YRPAPYRLKQ
260 270 280 290 300
WPYDTATTIG PGPPVQIVVT GFDPLTPVAP INALFSSFGE ISEINNRTDP
310 320 330 340 350
ITGRFLGVCS VKYKDSTSFR GAGPIPAATA ARRAYVECKK EQRIGTRRIR
360 370 380 390 400
VELDRDGAVS DRIVARAIES QRMGHKKNTV GEEAKIEPQA KKNEPPPTAP
410 420 430 440 450
KGPSRSSTRP AAAVPEGPRA SFLKPAMPSL IEETPILGQI KRDPYIFIAH
460 470 480 490 500
CYVPVLSTTI PHLKKRLKLF DWKDIRCDKT GYYIIFENSR RGEEETERCF
510 520 530 540 550
KVCHMKPLFT YIMNMESQPY GNPNYERSPS PERLQAERRE RAERERLKKE
560 570 580 590 600
ADLDLEEEKK QRAIDLDPCR EVLALIVRDL KDKLLEDVKS RIAAPTLYDY
610 620 630 640 650
LDPDRHAARR RALGIPDPEG IRRHTFQLDV DIFGSNNPQS SLPGGRSFSP
660 670 680 690 700
YGLNILALPR IRKARRLNRA HAAFLDERRK QPVRRKEVRP LYHRLQQLHD
710 720 730 740 750
VDDSDEDQRT PFSRDIDEQD SRPPSRMSSR SSISDDGEES EPLDGLASQD
760 770 780 790 800
KRHEARLLGL EYGDSGTTLN ETVDGYSRHD SPGLSSTRKR KRLAEGIEVR
810 820 830 840 850
KRPKEESERS ELNRSVETEN TLFYEESQHS EAAELGAVKP ENLAGIGGKF
860 870 880 890 900
LGRLEDRSIK EDGEKENVER LQIKSAIQGA DLDVQPPLPD ESTIAKSHED
910 920 930 940 950
PITEIEWGVS NDEPRPTVDD DETIILDLDG WQNLVKDEED LCFLRHVLDG
960 970 980 990 1000
QSRSKVGNLS AWAWRQKEIK ALNRPGESGP VHQETRIPDY YVCNPTGAAR
1010 1020 1030 1040 1050
TEGRKRILES EKSKYLPHRI KVQKAREERE ANAKSDPHAS AAEAARISAA
1060 1070 1080 1090 1100
KTISKSTSRS TRVNNRRLVA DINAQKQALP MQGGDGDVLR FNQLKKRKKP
1110 1120 1130 1140 1150
VRFARSAIHN WGLYAEENIS ANDMIIEYVG EKVRQQVADM RERQYLKSGI
1160 1170 1180 1190 1200
GSSYLFRIDE NTVIDATKRG GIARFINHSC TPNCTAKIIK VDGSKRIVIY
1210 1220 1230 1240
ALRDIGRDEE LTYDYKFERE WDSDDRIPCL CGSTGCKGFL N
Length:1,241
Mass (Da):139,380
Last modified:January 23, 2007 - v1
Checksum:i5410637BC4667BFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027698 Genomic DNA. Translation: EAW15850.1.
RefSeqiXP_001257747.1. XM_001257746.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00004713; CADNFIAP00004585; CADNFIAG00004713.
GeneIDi4584262.
KEGGinfi:NFIA_051950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027698 Genomic DNA. Translation: EAW15850.1 .
RefSeqi XP_001257747.1. XM_001257746.1.

3D structure databases

ProteinModelPortali A1DM29.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00004585.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00004713 ; CADNFIAP00004585 ; CADNFIAG00004713 .
GeneIDi 4584262.
KEGGi nfi:NFIA_051950.

Phylogenomic databases

HOGENOMi HOG000181654.
KOi K11422.
OMAi DKTGYYI.
OrthoDBi EOG7P8PH3.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181Imported.

Entry informationi

Entry nameiA1DM29_NEOFI
AccessioniPrimary (citable) accession number: A1DM29
Entry historyi
Integrated into UniProtKB/TrEMBL: January 23, 2007
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3