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A1DJ58

- BGALE_NEOFI

UniProt

A1DJ58 - BGALE_NEOFI

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Protein
Probable beta-galactosidase E
Gene
lacE, NFIA_000910
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921Substrate By similarity
Binding sitei136 – 1361Substrate By similarity
Binding sitei137 – 1371Substrate; via amide nitrogen By similarity
Binding sitei138 – 1381Substrate By similarity
Binding sitei195 – 1951Substrate By similarity
Active sitei196 – 1961Proton donor Reviewed prediction
Binding sitei261 – 2611Substrate By similarity
Active sitei299 – 2991Nucleophile Reviewed prediction
Binding sitei365 – 3651Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase E (EC:3.2.1.23)
Alternative name(s):
Lactase E
Gene namesi
Name:lacE
ORF Names:NFIA_000910
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 1011992Probable beta-galactosidase E
PRO_0000395244Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi202 – 2021N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi267 ↔ 316 By similarity
Glycosylationi406 – 4061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi423 – 4231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi455 – 4551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi588 – 5881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi622 – 6221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi704 – 7041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi745 – 7451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi759 – 7591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi772 – 7721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi778 – 7781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi913 – 9131N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi36630.CADNFIAP00000075.

Structurei

3D structure databases

ProteinModelPortaliA1DJ58.
SMRiA1DJ58. Positions 37-1011.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000181922.
OMAiGIDAYPM.
OrthoDBiEOG7ZGXBD.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEiPS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1DJ58-1 [UniParc]FASTAAdd to Basket

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MKFLLRRFIA LAAASSVVAA PSVSHLSLQD AANRRELLQD LVTWDQHSLF     50
VRGERLMIFS GEFHPFRLPV PGLWFDVFQK ITSLGFNAVS FYTDWGLMEG 100
NPGHVVTDGI WSLDEFFTAA SEAGIYLIAR PGPYINAETS AGGIPGWVLR 150
LKGIIRSNSE DYLRATDTYM ATLGKIIAKA QITNGGPVIL VQPENEYTTW 200
PNVSESEFPT TMNKEVMAYA EKQLRDAGVV VPTVVNDNKN LGYFAPGTGL 250
GETDLYGIDA YPMRYDCGNP YVWPTYRFPR DWQHTHRNHS PTTPFAIMEF 300
QGGSGDGWGG VTEDGCAILV NNEAVRVVYK NNYGFGVGVF NIYMTYGGTN 350
WGNLGYHGGY TSYDYGAAIT EDRQIWREKY SEEKLQANFL KVSPAYLTAT 400
PGNGVNGSYT GNKDIAVTPL FGNGTTTNFY LVRHADFTST GSVQYQLSVS 450
TSVGNVTIPQ LGGSLSLNGR DSKFHVTDYD VGEFNLIYSS AEIFTWAKGD 500
NKKRVLVLYG GAGELHEFAL PKHLPRPTVV DGSDVKMAKK GSAWVVQWEV 550
TAQRRVLRAG KLEIHLLWRN DAYQHWVLEL PAKQPIANYS SPSKETVLVK 600
GGYLLRSACI TNNKLHLTGD VNATTPLEVI SAPKRFDGIV FNGQSLKSTR 650
SKIGNLAATV RYQPPAISLP DLKRLDWKYL DSLPEISPDY SDEGWMSLTN 700
TYTNNTRKFT GPTCLYADDY GYHGGSLIYR GHFKANGDES WVFLNTSGGV 750
GFANSVWLNQ TFLGSWTGSG NNMTYPRNIS LPHELSPGKP YVFTVVIDHM 800
GQDEEAPGTD AIKFPRGILD YALSGHEVSD LKWKMTGNLG GEQYQDSTRG 850
PLNEGAMYAE RRGYHLPNPP TSSWKSSSPI NDGLTGAGIG FYATSFSLDL 900
PEGYDIPLSF LFNNSASDAR SGTSYRCQLF VNGYQFGKYV NDLGPQTNFP 950
VPEGILNYNG VNYVAVSLWA LEPQGALVGG LELVASTPIL SAYRKPVPAP 1000
QPGWKPRRGA Y 1011
Length:1,011
Mass (Da):111,421
Last modified:January 23, 2007 - v1
Checksum:i2E6518FE3F132FAC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027697 Genomic DNA. Translation: EAW16747.1.
RefSeqiXP_001258644.1. XM_001258643.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00000084; CADNFIAP00000075; CADNFIAG00000084.
GeneIDi4585646.
KEGGinfi:NFIA_000910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027697 Genomic DNA. Translation: EAW16747.1 .
RefSeqi XP_001258644.1. XM_001258643.1.

3D structure databases

ProteinModelPortali A1DJ58.
SMRi A1DJ58. Positions 37-1011.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 36630.CADNFIAP00000075.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00000084 ; CADNFIAP00000075 ; CADNFIAG00000084 .
GeneIDi 4585646.
KEGGi nfi:NFIA_000910.

Phylogenomic databases

eggNOGi COG1874.
HOGENOMi HOG000181922.
OMAi GIDAYPM.
OrthoDBi EOG7ZGXBD.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR019801. Glyco_hydro_35_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SMARTi SM01029. BetaGal_dom2. 1 hit.
[Graphical view ]
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
PROSITEi PS01182. GLYCOSYL_HYDROL_F35. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiBGALE_NEOFI
AccessioniPrimary (citable) accession number: A1DJ58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi