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A1DJ47

- EGLC_NEOFI

UniProt

A1DJ47 - EGLC_NEOFI

Protein

Probable glucan endo-1,3-beta-glucosidase eglC

Gene

eglC

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase By similarity.By similarity

    Catalytic activityi

    Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei128 – 1281NucleophileBy similarity
    Active sitei239 – 2391Proton donorBy similarity

    GO - Molecular functioni

    1. glucan endo-1,3-beta-D-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glucan endo-1,3-beta-glucosidase eglC (EC:3.2.1.39)
    Alternative name(s):
    Endo-1,3-beta-glucanase eglC
    Laminarinase eglC
    Gene namesi
    Name:eglC
    ORF Names:NFIA_000800
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity. Secretedcell wall By similarity
    Note: Covalently-linked GPI-modified cell wall protein.By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. cell wall Source: UniProtKB-SubCell
    3. extracellular region Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell wall, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 427409Probable glucan endo-1,3-beta-glucosidase eglCPRO_0000395151Add
    BLAST
    Propeptidei428 – 45023Removed in mature formSequence AnalysisPRO_0000395152Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis
    Lipidationi427 – 4271GPI-anchor amidated asparagineSequence Analysis

    Post-translational modificationi

    The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer By similarity.By similarity

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliA1DJ47.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi309 – 435127Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 17 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5309.
    HOGENOMiHOG000179527.
    OMAiTNTWWYI.
    OrthoDBiEOG7TBCCK.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1DJ47-1 [UniParc]FASTAAdd to Basket

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    MQFTQLVALA LALATSEAAH QGFNYGNTKS DGSAKSQSDF QAEFSTAKNL    50
    VGTSGFTSAR LYTMIQGGTA NTPISAIPAA VAEETSLLLG LWASGGNFAN 100
    EIAALKTAIA DYGDDLAKLV VGISVGSEDL YRNSVDGVKA KAGLGTNPDE 150
    IVSYINQVRS TIAGTKLSGA PIGHVDTWTA WVNGSNSAVI DACDWLGFDG 200
    YPYFQNTMAN SISDAKALFD ESVAKTEAVA KGKEVWITET GWPVSGNTEN 250
    LAVANLANAK TYWDEVGCPL FGKTNTWWYI LQDANPVTPN PSFGIVGSTL 300
    STTPLFDLSC SASSSAAASS TAVPSASSVA GAKASGFATA AASSGAAGSA 350
    KPTFTVGKGP GGSYNGTGFW NSTSSARPSS TAISGSSSGS ASGSSGSSGS 400
    GASGASGQSS SSTGSSSAPS SSNILSNAAS GLSGSIFGAV VAVCLALAAL 450
    Length:450
    Mass (Da):44,878
    Last modified:January 23, 2007 - v1
    Checksum:i1693931602240F26
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027697 Genomic DNA. Translation: EAW16736.1.
    RefSeqiXP_001258633.1. XM_001258632.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00000381; CADNFIAP00000372; CADNFIAG00000381.
    GeneIDi4585162.
    KEGGinfi:NFIA_000800.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027697 Genomic DNA. Translation: EAW16736.1 .
    RefSeqi XP_001258633.1. XM_001258632.1.

    3D structure databases

    ProteinModelPortali A1DJ47.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00000381 ; CADNFIAP00000372 ; CADNFIAG00000381 .
    GeneIDi 4585162.
    KEGGi nfi:NFIA_000800.

    Phylogenomic databases

    eggNOGi COG5309.
    HOGENOMi HOG000179527.
    OMAi TNTWWYI.
    OrthoDBi EOG7TBCCK.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiEGLC_NEOFI
    AccessioniPrimary (citable) accession number: A1DJ47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3