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A1DJ47

- EGLC_NEOFI

UniProt

A1DJ47 - EGLC_NEOFI

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Protein
Probable glucan endo-1,3-beta-glucosidase eglC
Gene
eglC, NFIA_000800
Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase By similarity.

Catalytic activityi

Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281Nucleophile By similarity
Active sitei239 – 2391Proton donor By similarity

GO - Molecular functioni

  1. glucan endo-1,3-beta-D-glucosidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan endo-1,3-beta-glucosidase eglC (EC:3.2.1.39)
Alternative name(s):
Endo-1,3-beta-glucanase eglC
Laminarinase eglC
Gene namesi
Name:eglC
ORF Names:NFIA_000800
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702: Unassembled WGS sequence

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor By similarity. Secretedcell wall By similarity
Note: Covalently-linked GPI-modified cell wall protein By similarity.

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. cell wall Source: UniProtKB-SubCell
  3. extracellular region Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell wall, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 427409Probable glucan endo-1,3-beta-glucosidase eglC
PRO_0000395151Add
BLAST
Propeptidei428 – 45023Removed in mature form Reviewed prediction
PRO_0000395152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi183 – 1831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi365 – 3651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi371 – 3711N-linked (GlcNAc...) Reviewed prediction
Lipidationi427 – 4271GPI-anchor amidated asparagine Reviewed prediction

Post-translational modificationi

The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer By similarity.

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Structurei

3D structure databases

ProteinModelPortaliA1DJ47.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi309 – 435127Ser-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5309.
HOGENOMiHOG000179527.
OMAiTNTWWYI.
OrthoDBiEOG7TBCCK.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A1DJ47-1 [UniParc]FASTAAdd to Basket

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MQFTQLVALA LALATSEAAH QGFNYGNTKS DGSAKSQSDF QAEFSTAKNL    50
VGTSGFTSAR LYTMIQGGTA NTPISAIPAA VAEETSLLLG LWASGGNFAN 100
EIAALKTAIA DYGDDLAKLV VGISVGSEDL YRNSVDGVKA KAGLGTNPDE 150
IVSYINQVRS TIAGTKLSGA PIGHVDTWTA WVNGSNSAVI DACDWLGFDG 200
YPYFQNTMAN SISDAKALFD ESVAKTEAVA KGKEVWITET GWPVSGNTEN 250
LAVANLANAK TYWDEVGCPL FGKTNTWWYI LQDANPVTPN PSFGIVGSTL 300
STTPLFDLSC SASSSAAASS TAVPSASSVA GAKASGFATA AASSGAAGSA 350
KPTFTVGKGP GGSYNGTGFW NSTSSARPSS TAISGSSSGS ASGSSGSSGS 400
GASGASGQSS SSTGSSSAPS SSNILSNAAS GLSGSIFGAV VAVCLALAAL 450
Length:450
Mass (Da):44,878
Last modified:January 23, 2007 - v1
Checksum:i1693931602240F26
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027697 Genomic DNA. Translation: EAW16736.1.
RefSeqiXP_001258633.1. XM_001258632.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00000381; CADNFIAP00000372; CADNFIAG00000381.
GeneIDi4585162.
KEGGinfi:NFIA_000800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS027697 Genomic DNA. Translation: EAW16736.1 .
RefSeqi XP_001258633.1. XM_001258632.1.

3D structure databases

ProteinModelPortali A1DJ47.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADNFIAT00000381 ; CADNFIAP00000372 ; CADNFIAG00000381 .
GeneIDi 4585162.
KEGGi nfi:NFIA_000800.

Phylogenomic databases

eggNOGi COG5309.
HOGENOMi HOG000179527.
OMAi TNTWWYI.
OrthoDBi EOG7TBCCK.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiEGLC_NEOFI
AccessioniPrimary (citable) accession number: A1DJ47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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