A1DIL2 (CYNS_NEOFI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyanate hydratase
Short name=Cyanase
EC=4.2.1.104

Alternative name(s):
Cyanate hydrolase
Cyanate lyase

Gene names

Name:	cyn1
ORF Names:	NFIA_091790

Organism

Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus) [Complete proteome]

Taxonomic identifier

331117 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Neosartorya › Neosartorya fischeri group › Neosartorya fischeri

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide By similarity. HAMAP-Rule MF_03139
Catalytic activity	Cyanate + HCO3- + 2 H+ = NH3 + 2 CO2. HAMAP-Rule MF_03139
Sequence similarities	Belongs to the cyanase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cyanate metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro cyanate hydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 160	160	Cyanate hydratase HAMAP-Rule MF_03139		PRO_0000403256
Sites
	Active site	100	1	By similarity
	Active site	103	1	By similarity
	Active site	126	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1DIL2 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 0EFC1514AEE379D9	FASTA	160	17,810
	10 20 30 40 50 60 MSLATLDATQ HPNLPASAAT LFKAKAQNKL SFEQIAQHIG RNEVATAALF YGQAKASPED 70 80 90 100 110 120 IQKLSELLNI SPQVLEEQLS GFPDRGRSVE MPPKEPLIYR LYEIVQNYGY AYKAVLNEKF 130 140 150 160 GDGIMSAISF STKVEKETDA DGNNWAVITL RGKWLPFSRF

References

[1]

"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M. , Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C. PLoS Genet. 4:E1000046-E1000046(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS027696 Genomic DNA. Translation: EAW19219.1.
RefSeq	XP_001261116.1. XM_001261115.1.
3D structure databases
ProteinModelPortal	A1DIL2.
ModBase	Search...
Protein-protein interaction databases
STRING	36630.CADNFIAP00007214.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADNFIAT00007381; CADNFIAP00007214; CADNFIAG00007381.
GeneID	4587674.
KEGG	nfi:NFIA_091790.
Phylogenomic databases
eggNOG	COG1513.
HOGENOM	HOG000043436.
KO	K01725.
OrthoDB	EOG4MGWHS.
Family and domain databases
Gene3D	1.10.260.40. 1 hit. 3.30.1160.10. 1 hit.
HAMAP	MF_00535. Cyanate_hydrat.
InterPro	IPR008076. Cyanase. IPR003712. Cyanate_lyase_C. IPR010982. Lambda_DNA-bd_dom. [Graphical view]
Pfam	PF02560. Cyanate_lyase. 1 hit. [Graphical view]
PIRSF	PIRSF001263. Cyanate_hydratas. 1 hit.
PRINTS	PR01693. CYANASE.
SUPFAM	SSF55234. Cyanate_lyase_C. 1 hit. SSF47413. Lambda_like_DNA. 1 hit.
TIGRFAMs	TIGR00673. cynS. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYNS_NEOFI

Accession

Primary (citable) accession number: A1DIL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2011
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program