ID   XLNR_NEOFI              Reviewed;         950 AA.
AC   A1DIC0;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 2.
DT   24-JAN-2024, entry version 78.
DE   RecName: Full=Xylanolytic transcriptional activator xlnR;
DE   AltName: Full=Xylanase regulator;
GN   Name=xlnR; ORFNames=NFIA_090850;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC   NRRL 181 / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Transcriptional activator of the xylanolytic system. Involved
CC       in the regulation of extracellular cellulolytic and xylanolytic genes
CC       and in the regulation of the intracellular activities of D-xylose
CC       catabolic genes in the pentose catabolic pathway (PCP) in response to
CC       the presence of D-xylose (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the xlnR/xlr1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAW19127.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=EAW19127.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; DS027696; EAW19127.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001261024.1; XM_001261023.1.
DR   AlphaFoldDB; A1DIC0; -.
DR   SMR; A1DIC0; -.
DR   STRING; 331117.A1DIC0; -.
DR   GeneID; 4587582; -.
DR   KEGG; nfi:NFIA_090850; -.
DR   VEuPathDB; FungiDB:NFIA_090850; -.
DR   eggNOG; ENOG502QUI0; Eukaryota.
DR   OrthoDB; 2734143at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISS:UniProtKB.
DR   GO; GO:0045493; P:xylan catabolic process; ISS:UniProtKB.
DR   CDD; cd12148; fungal_TF_MHR; 1.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; Zn(2)-C6 fungal-type DNA-binding domain; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   InterPro; IPR001138; Zn2Cys6_DnaBD.
DR   PANTHER; PTHR47663; XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED; 1.
DR   PANTHER; PTHR47663:SF1; XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED; 1.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; Zn2/Cys6 DNA-binding domain; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..950
FT                   /note="Xylanolytic transcriptional activator xlnR"
FT                   /id="PRO_0000393157"
FT   DNA_BIND        119..145
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          300..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          561..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..97
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..246
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..329
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        568..586
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   950 AA;  103771 MW;  606F9D26F41F36D9 CRC64;
     MSTTSLQHFS HSYSPFPSSR SSNRMAQSQT SGLDTLAEGS QYALEQLQMS REAAGDGEAT
     NSMGKPKDQY QIDNDNHHNN HSLPSFKNSS QRDPLVEARS TIRKNSASAP VRRRISRACD
     QCNQLRTKCD GQNPCAHCIE FGLTCEYARE RKKRGKASKK DLAAAAAAAT NPGQPNGSSG
     KEDAAMVGGH TSPDRRPTLN GRYDPAFEVP RNLNGSAQHS EASGMVGMQN SQHLPPHSQS
     SMGGGLEGLS LNGYNGLNDS SRPSMPVPEL QSLHMLHNSH TNPRSPSSVL PHHRYNGGYN
     DSAYSLMNPQ EPNSTSISHF RLGSSTENPP NSFLGLSPPA QSPGWLPLPS PSPANFPSFS
     MASFSTTLRY PVLHPVLPHI ASIIPQSLAC DLLDVYFTSS SSSHLSPQSP YVVGYIFRKQ
     SFLHPTKPRV CTPGLLASML WVAAQTSDAP FLTSPPSARG RVCQKLLELT IGLLRPLIHG
     PAPGETSPNY AANMVINGVA LGGFGVSMDQ LGAQSSATGA VDDVATYVHL ATVISASEYK
     AASMRWWTAA WSLARELKLG RELPPNTPHS RPDAERDGDP DADLSKRHPP PLITSMGHGP
     GNTVINITEE EREERRRLWW LLYATDRHLA LCYNRPLTLL DKECEGLLQP MNDDLWQAGD
     FATYRQAGPP VECTGHSMFG YFLPLMTILG EIVDLQQARN HPRFGLAFRN SAECEAQVLE
     IARQLDVYAQ SLKEFETRYT SSLALGAAET EAAMEGSHLN HVSPSGRSSS TVESRVNESI
     VHTKMVVAYG THIMHVLHIL LAGKWDPINL LDDNDLWISS ESFVAAMGHA VGAAEAASEI
     LEYDPDLSFM PFFFGIYLLQ GSFLLLLTAD KLQGDASPSV VRACETIVRA HEACVVTLNT
     EYQRTFRKVM RSALAQVRGR LPEDFGEQQQ RRREVLALYR WTGDGSGLAL
//