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Protein

Mitochondrial thiamine pyrophosphate carrier 1

Gene

tpc1

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.By similarity

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial thiamine pyrophosphate carrier 1
Gene namesi
Name:tpc1
ORF Names:NFIA_090220
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_090220.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 35Helical; Name=1Sequence analysisAdd BLAST19
Transmembranei91 – 107Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei126 – 146Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei181 – 198Helical; Name=4Sequence analysisAdd BLAST18
Transmembranei220 – 240Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei284 – 301Helical; Name=6Sequence analysisAdd BLAST18

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003204691 – 317Mitochondrial thiamine pyrophosphate carrier 1Add BLAST317

Structurei

3D structure databases

ProteinModelPortaliA1DI57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 110Solcar 1Add BLAST99
Repeati120 – 206Solcar 2Add BLAST87
Repeati214 – 309Solcar 3Add BLAST96

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000165726.
KOiK15108.
OMAiWKGNVPA.
OrthoDBiEOG092C3KDM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

A1DI57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGGEHLKD EGTRRQVVLS GGIAGLVSRF CVAPLDVVKI RLQLQIHSLS
60 70 80 90 100
DPASHRDVVG PIYKGTLSTM RAIIKQEGIT GLWKGNIPAE LMYVCYGALQ
110 120 130 140 150
FTAYRTTTQV LAQLDPHRLP PALESFVSGA VAGGLATAST YPLDLLRTRF
160 170 180 190 200
AAQGTERIYT SLLASVQDIA RNEGPAGFFR GCSAAVGQIV PYMGLFFATY
210 220 230 240 250
ESLRPVLSGL ENMPFGSGDA AAGVIASVLA KTGVFPLDLV RKRLQVQGPT
260 270 280 290 300
RTLYVHRNIP EYRGVFSTIA MIVRTQGVRG LYRGLTVSLI KAAPASAITM
310
WTYERSLKLL HDFRVAE
Length:317
Mass (Da):34,285
Last modified:January 23, 2007 - v1
Checksum:i046934E49C8C9955
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027696 Genomic DNA. Translation: EAW19064.1.
RefSeqiXP_001260961.1. XM_001260960.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00007341; CADNFIAP00007174; CADNFIAG00007341.
GeneIDi4587519.
KEGGinfi:NFIA_090220.

Similar proteinsi

Entry informationi

Entry nameiTPC1_NEOFI
AccessioniPrimary (citable) accession number: A1DI57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families