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Protein

Mitochondrial thiamine pyrophosphate carrier 1

Gene

tpc1

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.By similarity

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial thiamine pyrophosphate carrier 1
Gene namesi
Name:tpc1
ORF Names:NFIA_090220
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_090220

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 35Helical; Name=1Sequence analysisAdd BLAST19
Transmembranei91 – 107Helical; Name=2Sequence analysisAdd BLAST17
Transmembranei126 – 146Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei181 – 198Helical; Name=4Sequence analysisAdd BLAST18
Transmembranei220 – 240Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei284 – 301Helical; Name=6Sequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003204691 – 317Mitochondrial thiamine pyrophosphate carrier 1Add BLAST317

Structurei

3D structure databases

ProteinModelPortaliA1DI57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 110Solcar 1Add BLAST99
Repeati120 – 206Solcar 2Add BLAST87
Repeati214 – 309Solcar 3Add BLAST96

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000165726
KOiK15108
OMAiWKGNVPA
OrthoDBiEOG092C3KDM

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

A1DI57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGGEHLKD EGTRRQVVLS GGIAGLVSRF CVAPLDVVKI RLQLQIHSLS
60 70 80 90 100
DPASHRDVVG PIYKGTLSTM RAIIKQEGIT GLWKGNIPAE LMYVCYGALQ
110 120 130 140 150
FTAYRTTTQV LAQLDPHRLP PALESFVSGA VAGGLATAST YPLDLLRTRF
160 170 180 190 200
AAQGTERIYT SLLASVQDIA RNEGPAGFFR GCSAAVGQIV PYMGLFFATY
210 220 230 240 250
ESLRPVLSGL ENMPFGSGDA AAGVIASVLA KTGVFPLDLV RKRLQVQGPT
260 270 280 290 300
RTLYVHRNIP EYRGVFSTIA MIVRTQGVRG LYRGLTVSLI KAAPASAITM
310
WTYERSLKLL HDFRVAE
Length:317
Mass (Da):34,285
Last modified:January 23, 2007 - v1
Checksum:i046934E49C8C9955
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027696 Genomic DNA Translation: EAW19064.1
RefSeqiXP_001260961.1, XM_001260960.1

Genome annotation databases

EnsemblFungiiCADNFIAT00007341; CADNFIAP00007174; CADNFIAG00007341
GeneIDi4587519
KEGGinfi:NFIA_090220

Similar proteinsi

Entry informationi

Entry nameiTPC1_NEOFI
AccessioniPrimary (citable) accession number: A1DI57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health