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A1DHY9

- EGLX_NEOFI

UniProt

A1DHY9 - EGLX_NEOFI

Protein

Probable endo-1,3(4)-beta-glucanase NFIA_089530

Gene

NFIA_089530

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates.By similarity

    Catalytic activityi

    Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei145 – 1451NucleophileBy similarity
    Active sitei150 – 1501Proton donorBy similarity

    GO - Molecular functioni

    1. glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC
    2. glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable endo-1,3(4)-beta-glucanase NFIA_089530 (EC:3.2.1.6)
    Alternative name(s):
    Mixed-linked glucanase NFIA_089530
    Gene namesi
    ORF Names:NFIA_089530
    OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
    Taxonomic identifieri331117 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
    ProteomesiUP000006702: Unassembled WGS sequence

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 629608Probable endo-1,3(4)-beta-glucanase NFIA_089530PRO_0000395095Add
    BLAST
    Propeptidei630 – 65122Removed in mature formSequence AnalysisPRO_0000395096Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Lipidationi629 – 6291GPI-anchor amidated asparagineSequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliA1DHY9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi332 – 506175Ala-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 16 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000166269.
    OMAiSCVNYVA.
    OrthoDBiEOG7HB5KN.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000757. Glyco_hydro_16.
    [Graphical view]
    PfamiPF00722. Glyco_hydro_16. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A1DHY9-1 [UniParc]FASTAAdd to Basket

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    MAPSSLFLSV GSLIASSLVS ATALEARQSQ TYQLAESWQG ESFINDWNFF    50
    DRADPTNGYV TYVNQSFAEQ SGLVKVTQSG SFYMGVDYES TLNPNGPGRE 100
    SVRIETKNYY TEGLYVIDIE HMPGSICGTW PAFWSVGKDW PNDGEIDIIE 150
    GVNLQKANKI VLHTSGSCDV SGSNDMTGTL SSSECGEASG TVGCVVKGTN 200
    GSSGDPFNEA GGGVYAMEWT DTFIKIWFFP RSQIPASLSS GNPDTSSFGT 250
    PMAHLQGSCD FAERFKAQKF IIDTTFCGDW AGNVFAESTC PMSDPSSPMQ 300
    SCVNYVAQNP AAFKEAYWEI NSIKVYQYGV SAASSAAVSQ ATASKVEGTL 350
    VSVQAANTAT PTVPVPAETT AVPQPAQTNT VATSAADYAT QSSAETTTVP 400
    AATGAPSVSA AEGGDSELES TSTVYVTSTT TICPVAESSS AAAAGGKKDA 450
    PFNGVSGAEV AATSVAAAPA AATSEHPGAD AIANSAAATS TVAKSEGVAS 500
    QLTAGALSEI PTAPPEPVSQ AVSTGSFDDS DTAQGDSEEH GSIASASAAP 550
    STIPVPASSS AAALGGSSIA SSFASSRLVP RPTGSSTAAS VTAIATWSPT 600
    AGERASGTAK GSATLTAPSE VVFTPGLSNG ANRMSVGLSG LIGVMFIAAL 650
    A 651
    Length:651
    Mass (Da):66,035
    Last modified:January 23, 2007 - v1
    Checksum:i0DD6CA7D45C885A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027696 Genomic DNA. Translation: EAW18996.1.
    RefSeqiXP_001260893.1. XM_001260892.1.

    Genome annotation databases

    EnsemblFungiiCADNFIAT00007993; CADNFIAP00007826; CADNFIAG00007993.
    GeneIDi4587451.
    KEGGinfi:NFIA_089530.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS027696 Genomic DNA. Translation: EAW18996.1 .
    RefSeqi XP_001260893.1. XM_001260892.1.

    3D structure databases

    ProteinModelPortali A1DHY9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADNFIAT00007993 ; CADNFIAP00007826 ; CADNFIAG00007993 .
    GeneIDi 4587451.
    KEGGi nfi:NFIA_089530.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000166269.
    OMAi SCVNYVA.
    OrthoDBi EOG7HB5KN.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000757. Glyco_hydro_16.
    [Graphical view ]
    Pfami PF00722. Glyco_hydro_16. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

    Entry informationi

    Entry nameiEGLX_NEOFI
    AccessioniPrimary (citable) accession number: A1DHY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3