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Protein

Probable E3 ubiquitin ligase complex SCF subunit sconB

Gene

sconB

Organism
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.By similarity

Pathwayi

GO - Biological processi

  1. DNA replication initiation Source: EnsemblFungi
  2. protein polyubiquitination Source: EnsemblFungi
  3. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: EnsemblFungi
  4. regulation of DNA-dependent DNA replication initiation Source: EnsemblFungi
  5. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: EnsemblFungi
  6. response to arsenic-containing substance Source: EnsemblFungi
  7. response to cadmium ion Source: EnsemblFungi
  8. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: EnsemblFungi
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin ligase complex SCF subunit sconB
Alternative name(s):
Sulfur controller B
Sulfur metabolite repression control protein B
Gene namesi
Name:sconB
ORF Names:NFIA_089300
OrganismiNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
Taxonomic identifieri331117 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeNeosartorya
ProteomesiUP000006702 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:NFIA_089300.

Subcellular locationi

GO - Cellular componenti

  1. nuclear SCF ubiquitin ligase complex Source: EnsemblFungi
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689Probable E3 ubiquitin ligase complex SCF subunit sconBPRO_0000397253Add
BLAST

Interactioni

Subunit structurei

Component of the SCF(sconB) E3 ubiquitin ligase complex.By similarity

Protein-protein interaction databases

STRINGi36630.CADNFIAP00006688.

Structurei

3D structure databases

ProteinModelPortaliA1DHW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 23247F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati358 – 39538WD 1Add
BLAST
Repeati398 – 43740WD 2Add
BLAST
Repeati439 – 47537WD 3Add
BLAST
Repeati477 – 51842WD 4Add
BLAST
Repeati572 – 61544WD 5Add
BLAST
Repeati616 – 65540WD 6Add
BLAST
Repeati658 – 68932WD 7Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000166480.
KOiK10259.
OMAiMCLQFSE.
OrthoDBiEOG7C5MHX.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinonprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 2 hits.
SSF81383. SSF81383. 2 hits.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1DHW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAHELSFRD GHGSSTSTMK DECASEEKAL YLPGDSSFAS VFGPSETVED
60 70 80 90 100
VETGPESTQD KPHSFNTQKP IREKLAGKNV APFLARHIPE QYAPLGSQTG
110 120 130 140 150
QPVEISSANS KYCYRHRPDL KCRRQADEPT MDKLQRSDQQ GIAHAWSIFS
160 170 180 190 200
AAPAKHRKLI LQGIMAQCCF PQLSFISATV RDLIRIDFLT ALPPEISFKI
210 220 230 240 250
LCYLDTTSLC KAAQVSRRWR ALADDDVVWH RMCEQHIHRK CKKCGWGLPL
260 270 280 290 300
LDRKRLRESK REIERRAATW DVSEQPAETE SNSATIDTAA SGSKRKPESD
310 320 330 340 350
KEDTAMVKRQ CTSIVSQSEQ NEDYFKTRYR PWKEVYKDRF KVGTNWKYGR
360 370 380 390 400
CSIRVFKGHS NGIMCLQFED NILATGSYDA TIKIWDTETG EELRTLKGHR
410 420 430 440 450
SGIRCLQFDD TKLISGSMDH TLKVWNWRTG ECISTYSGHR GGVVGLHFDA
460 470 480 490 500
TILASGSVDK TVKIWNFEDK STCLLRGHTD WVNAVRVDSA SRTVFSASDD
510 520 530 540 550
CTVKLWDLDT KSCIRTFHGH VGQVQQVVPL PREFEFEDHD VECENDNVSV
560 570 580 590 600
TSGDSPAASP QAIPGFDAQT SDTPSSAFGP AFDDGRPSPP RYIVTSALDS
610 620 630 640 650
TIRLWETSSG RCLRTFFGHL EGVWALAADT LRIVSGAEDR MVKIWDPRTG
660 670 680
KCERTFTGHS GPVTCIGLGD SRFATGSEDC EVRMYSFQT
Length:689
Mass (Da):77,242
Last modified:January 23, 2007 - v1
Checksum:iB87ACA25A35F4994
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027696 Genomic DNA. Translation: EAW18973.1.
RefSeqiXP_001260870.1. XM_001260869.1.

Genome annotation databases

EnsemblFungiiCADNFIAT00006855; CADNFIAP00006688; CADNFIAG00006855.
GeneIDi4587428.
KEGGinfi:NFIA_089300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS027696 Genomic DNA. Translation: EAW18973.1.
RefSeqiXP_001260870.1. XM_001260869.1.

3D structure databases

ProteinModelPortaliA1DHW6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi36630.CADNFIAP00006688.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADNFIAT00006855; CADNFIAP00006688; CADNFIAG00006855.
GeneIDi4587428.
KEGGinfi:NFIA_089300.

Organism-specific databases

EuPathDBiFungiDB:NFIA_089300.

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000166480.
KOiK10259.
OMAiMCLQFSE.
OrthoDBiEOG7C5MHX.

Enzyme and pathway databases

UniPathwayiUPA00143.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR011047. Quinonprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50998. SSF50998. 2 hits.
SSF81383. SSF81383. 2 hits.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181.

Entry informationi

Entry nameiSCONB_NEOFI
AccessioniPrimary (citable) accession number: A1DHW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: January 23, 2007
Last modified: April 29, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.